CAS: 1450-86-8; Pyrimidine-4(3H)-Thione

该化合物是一种杂环化合物,其特征是具有硫醇组,具有一种丙酰环,具有六人芳香环,含有1和3个位置的两个氮原子,其中硫磺原子替代碳基组,具有4个位置的碳基;典型的黄到褐固体,在极有机溶剂中可溶解;硫醇组的存在具有独特的化学再活性,使其得以参与各种核生殖反应和金属复合体. 4(1H)-丙酰胺磷因其潜在的生物活动,包括抗微生物和抗硫素特性,对医药化学和农业应用具有兴趣.此外,它可以作为合成其他丙胺衍生物的前体.与许多含有硫磺化合物一样,它可能具有独特的化学特性,使其得以参与各种核循环反应和金属组合体.

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591-28-6 89185-13-7 2001-93-6

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上下游产品

CAS号51953-17-4 4-羟基嘧啶

合成工艺路线路线简述

  • 合成目标产物 4(1H)-Pyrimidinethione (9CI) 主要起始原料 4-Hydroxypyrimidine
  • (文献来源)合成步骤主要原料 4-Hydroxypyrimidine
📜4-Chloropyrimidine Hydrochloride置于sodium Hydrogensulfide体系中,化学反应生成4-巯基嘧啶
参考文献:Cornforth; Zit. Bei Boarland; Mcomie,Journal Of The Chemical Society,1951,P. 1218,1221
标题:Cornforth; Zit. Bei Boarland; Mcomie,Journal Of The Chemical Society,1951,P. 1218,1221

专利信息


专利号:US-8492390-B2
优先权日:2002-05-08
标题 :Synthesis of locked nucleic acid derivatives
发明人:DETLEF SORENSEN MADS; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER
权利人:DETLEF SORENSEN MADS; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER; SANTARIS PHARMA AS
摘要:The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α- L -oxy-LNA, amino-LNA, α- L -amino-LNA, thio-LNA, α- L -thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.

专利号:EP-1501848-B1
优先权日:2002-05-08
标 题 :Synthesis of locked nucleic acid derivatives
发明人:SORENSEN MADS DETLEF; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER
权利人:SANTARIS PHARMA AS
摘要:The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as alpha-L-oxy-LNA, amino-LNA, alpha-L-amino-LNA, thio-LNA, alpha-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues. (Formula I)

专利号:US-11920171-B1
优先权日:2016-05-06
标题:Synthesis and oxidation of methane
发明人:MANSOORABADI STEVEN
权利人:UNIV AUBURN
摘要:The present disclosure describes genes and proteins of the coenzyme F430 synthetic pathway. The genes and proteins in the pathway find uses as isolated nucleic acids, transformation vectors, a transformation media, genetically modified cells, methods of modulating methanogenesis, methods of modulating methane oxidation, methods of making a tetrapyrrole compound, methods of oxidizing methane, methods of biogenic methane synthesis is provided, methods of assaying an organism for potential methanogenic or methanotrophic activity, and isolated proteins.

专利号:US-2004014959-A1
优先权日:2002-05-08
标题:Synthesis of locked nucleic acid derivatives

专利号:CN-1423654-A
优先权日:1999-11-12
标题:Synthesis of 2' -deoxy-L-nucleosides

专利号:CN-1620295-A
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides

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✅ COA系统入驻 | 共享模式

合成参考文献


摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 103.
摘要:A. Albert and G. B. Barlin. J. Chem. Soc. 1962, 3129.
摘要:B. Stanovnik and M. Tisler. Arzneimittel-Forsch. 14, 1004 (1964).
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