📜4-Chloropyrimidine Hydrochloride置于sodium Hydrogensulfide体系中,化学反应生成4-巯基嘧啶 参考文献:Cornforth; Zit. Bei Boarland; Mcomie,Journal Of The Chemical Society,1951,P. 1218,1221 标题:Cornforth; Zit. Bei Boarland; Mcomie,Journal Of The Chemical Society,1951,P. 1218,1221
专利信息
专利号:US-8492390-B2 优先权日:2002-05-08 标题 :Synthesis of locked nucleic acid derivatives 发明人:DETLEF SORENSEN MADS; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER 权利人:DETLEF SORENSEN MADS; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER; SANTARIS PHARMA AS 摘要:The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α- L -oxy-LNA, amino-LNA, α- L -amino-LNA, thio-LNA, α- L -thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.
专利号:EP-1501848-B1 优先权日:2002-05-08 标 题 :Synthesis of locked nucleic acid derivatives 发明人:SORENSEN MADS DETLEF; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER 权利人:SANTARIS PHARMA AS 摘要:The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as alpha-L-oxy-LNA, amino-LNA, alpha-L-amino-LNA, thio-LNA, alpha-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues. (Formula I)
专利号:US-11920171-B1 优先权日:2016-05-06 标题:Synthesis and oxidation of methane 发明人:MANSOORABADI STEVEN 权利人:UNIV AUBURN 摘要:The present disclosure describes genes and proteins of the coenzyme F430 synthetic pathway. The genes and proteins in the pathway find uses as isolated nucleic acids, transformation vectors, a transformation media, genetically modified cells, methods of modulating methanogenesis, methods of modulating methane oxidation, methods of making a tetrapyrrole compound, methods of oxidizing methane, methods of biogenic methane synthesis is provided, methods of assaying an organism for potential methanogenic or methanotrophic activity, and isolated proteins.
专利号:US-2004014959-A1 优先权日:2002-05-08 标题:Synthesis of locked nucleic acid derivatives
专利号:CN-1423654-A 优先权日:1999-11-12 标题:Synthesis of 2' -deoxy-L-nucleosides
专利号:CN-1620295-A 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 103. 摘要:A. Albert and G. B. Barlin. J. Chem. Soc. 1962, 3129. 摘要:B. Stanovnik and M. Tisler. Arzneimittel-Forsch. 14, 1004 (1964).