CAS: 1444-94-6; 1,2-Cyclohexanedicarboximide

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CAS号1469-48-3 顺式-1,2,3,6-四氢吩胺 | CAS号64-19-7 冰醋酸 | CAS号21850-12-4 顺式-全氢异吲哚 | CAS号99012-87-0 cis-N-(4-Bromob...

在 1-羟基-2,2,6,6-四甲基哌啶,2,6-Di(T-Butyl)-4-Phenylphenol,Sodium Carbonate体系中,用 N,N-二甲基乙酰胺 用作溶剂,化学反应 10.0H,以96%的收率获得六氢邻苯二甲酰亚胺
参考文献:可见光或近可见光引发的选择性脱除苄基,烯丙基和炔丙基类保护基的方法
标题:可见光或近可见光引发的选择性脱除苄基,烯丙基和炔丙基类保护基的方法
摘要:本发明提供了一种可见光或近可见光引发的选择性脱除苄基,烯丙基和炔丙基类保护基的方法,即含苄基,烯丙基或炔丙基类保护基的底物,在酚催化剂,碱,氢源和光的作用下,通过自由基裂解反应,得到目标选择性脱保护基的产物;本方法操作简单,采用安全清洁的可见光或近可见光为激发条件,试剂便宜易得,反应产率高,反应的化学和区域选择性高,适用于各种底物中苄基,烯丙基和炔丙基类保护基的选择性脱除.

专利信息

专利号:US-5736535-A
优先权日:1992-04-16
标 题:1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase
发明人：BERNSTEIN PETER ROBERT; EDWARDS PHILIP DUKE; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; VEALE CHRIS ALLAN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.

专利号:US-5254558-A
优先权日:1991-08-15
标 题:Substituted 1,3-diazines as leukocyte elastase inhibitors
发明人：BERNSTEIN PETER R; EDWARDS PHILIP D; THOMAS ROYSTON M; VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ICI PLC
摘要:The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.

专利号:WO-9321213-A1
优先权日:1992-04-16
标题 :Alpha-aminoboronic acid peptides and their use as elastase inhibitors
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic derivatives which are 1-pyridylacetamide derivatives of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases on mammals in which (HLE) is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic derivatives, processes for preparing the heterocyclic derivatives, pharmaceutical compositions containing such heterocyclic derivatives and methods for their use.

专利号:US-5721222-A
优先权日:1992-04-16
标 题 :Heterocyclic ketones
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; THOMAS ROYSTON MARTIN; VEALE CHRIS ALLAN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.

专利号:CN-115108962-A
优先权日:2022-08-01
标 题:A kind of method for continuous synthesis of azabicyclic compounds

专利号:US-5441960-A
优先权日:1992-04-16
标题:1-pyrimidinylacetamide human leukocyte elastate inhibitors
发明人：BERNSTEIN PETER R; EDWARDS PHILIP D; SHAW ANDREW; THOMAS ROYSTON M; VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel substituted ketones which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates ##STR2## useful in the synthesis of these substituted ketones processes for preparing the substituted ketones pharmaceutical compositions containing such substituted ketones and methods for their use.