CAS: 13991-36-1; (E)-4-Bromobut-2-Enoic Acid

上下游产品

CAS号107-93-7 巴豆酸 | CAS号26340-58-9 (E)-4-氯丁-2-烯酸 | CAS号1117-71-1 4-溴巴豆酸甲酯 | CAS号128-08-5 N-溴代丁二酰亚胺 | CAS号37746-78-4 4-溴巴豆酸乙酯 | CAS号3724-65-0 巴豆酸 | CAS号625-38-7 乙烯基乙酸 | CAS号88239-39-8 trimethylsilyl ... | CAS号600-17-9 2-Hydroxy-3-but... | CAS号10035-10-6 氢溴酸 | CAS号24806-06-2 4-chlorobut-2-e... | CAS号98548-82-4 4-(二甲氨基)丁-2-烯酸 | CAS号15790-94-0 (E)-2-十一烯酸 | CAS号1117-71-1 4-溴巴豆酸甲酯 | CAS号13419-69-7 反-2-己烯酸 | CAS号24587-49-3 (E)-4-羟基-2-丁烯酸 | CAS号38090-53-8 7-氨基-3-[(1H-1,2...

巴豆酸置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 苯 用作溶剂,化学反应 4.0H,以50%的收率获得4-溴巴豆酸
参考文献:Direct And Two-Step Bioorthogonal Probes For Bruton'S Tyrosine Kinase Based On Ibrutinib: A Comparative Study
标题:Direct And Two-Step Bioorthogonal Probes For Bruton'S Tyrosine Kinase Based On Ibrutinib: A Comparative Study
摘要:直接和两步法活性基础探针可用于在体外和原位对布鲁顿酪氨酸激酶进行分析.
Doi:10.1039/c5Ob00474H

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:US-7126025-B2
优先权日:2003-01-21
标 题 :Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
发明人：CONSIDINE JOHN LEO; DAIGNEAULT SYLVAIN; CHEW WARREN; IERA SILVIO; DUNCAN SCOTT MASON; REN JIANXIN
权利人:WYETH CORP
摘要:This invention provides a compound of Formula (I): n nwhereinn S 1 and S 2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S 1 and S 2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:WO-03013740-A1
优先权日:2001-08-03
标题 :4- AND 5-AMINO-α, β UNSTATURATED ESTER SOLID SUPPORT TEMPLATES, METHOD OF PREPARATION AND FOR USING THE SAME
发明人：LOU BOLIANG; MAJJLI ADNAN M M
权利人:ADVANCED SYNTECH LLC
摘要:A substituted α, β-unsaturated ester template of the general formula (1) where: P is an insoluble substrate; n is 1 or 2; X is an atom or a functional group connecting the polymer and the linker L. having a structure such as but not limited to oxygen, ester, amide, sulfur, silicon and carbon; L is a multifunctional chemical monomer in which one functional group reacts with the polymer to form a covalent bond (X) and one other of the functional groups react with one of the R groups (R1, R2, R3, R5, or R6) through a plurality of chemical reactions to provide the desired templates for further chemistry. The ester template is useful for the solid phase synthesis of heterocycle compounds.

专利号:US-9193682-B2
优先权日:2013-04-05
标题:Synthesis of trithiocarbonates and allyl sulfides and their application into advances in covalent adaptable networks
发明人：FENOLI CHRISTOPHER R; BOWMAN CHRISTOPHER N
权利人:FENOLI CHRISTOPHER R; BOWMAN CHRISTOPHER N
摘要:Monomers having a C-B-A-B-C structure are disclosed, where A is a core of either trithiocarbonate and allyl sulfide, where B are linker units, and where C are end units. The end units may comprise acrylates, methacrylates, alcohol(s), amine(s), and alkynes, among others. The linker units may include an alkane, alkene, phenyl, diphenyl, or benzylic group, among others. Methods of synthesizing such compounds are also disclosed.