CAS: 129604-28-0; 2-Chloro-6-(Trifluoromethyl)Benzonitrile

相似化合物

2376-00-3 60611-22-5 89223-58-5

上下游产品

2-chloro-6-nitrobenzonitrile (trifluoromethyl)trimethylsilane 2-chloro-6-trichloromethyl benzonitrile sodium cyanide 8H6ClF3N2°C8H6ClF3N2O 2-(3-hydroxyphenoxy)-6-(trifluoromethyl)benzonitrile 1-(2-chloro-6-(trifluoromethyl)phenyl)ethan-1-one 2-fluoro-6-(trifluoromethyl)benzonitrile

📜2,3-二氯三氟甲苯置于potassium Fluoride,三苯基膦氢溴酸盐体系中,用 N,N-二甲基乙酰胺 用作溶剂,化学反应 5.0H,反应生成3-氯-2-氰基三氟甲苯
参考文献:一种氟吡菌酰胺的合成方法
标题:一种氟吡菌酰胺的合成方法
摘要:本发明公开了一种氟吡菌酰胺的合成方法,包括:将2,3‑二氯三氟甲苯经过氟化,氰基取代,水解,羟甲基化,酯化制得中间体5;另将2,3‑二氯‑5‑三氟甲基吡啶与丙二酸二酯反应制得中间体6;将中间体5与中间体6缩合后,再进行水解,脱羧,最后氢化脱氯制得氟吡菌酰胺.本发明具有操作简单,原料廉价易得,中间体1的异构体不参与后续反应,且易除去的特点.各反应步骤中未使用现有合成方法中常用的易燃易爆,剧毒或不易保存的试剂,避免对环境以及操作人员的危害;同时,产品的收率达到50%以上,纯度则在98%以上.

专利信息

专利号:US-6156922-A
优先权日:1995-12-28
标题 :Method for the synthesis of an aromatic derivative ortho-disubstituted by a halogen atom other than fluorine and by a cyano group
发明人：RUSSELL JAMES; GILBERT LAURENT; MAESTRO JEAN PIERRE
权利人:RHODIA CHIMIE SA
摘要:PCT No. PCT/FR96/02100 Sec. 371 Date Sep. 15, 1998 Sec. 102(e) Date Sep. 15, 1998 PCT Filed Dec. 27, 1996 PCT Pub. No. WO97/24318 PCT Pub. Date Jul. 10, 1997The present invention relates to a method for the synthesis of a halogen substituted aryl nitrile, where the halogens are selected from Cl, Br, or I, by reacting an aryl dihalide with a halogen/fluoride exchange reactant to produce a halogen substituted aryl fluoride which is then reacted with a fluoride/cyanide exchange reactant to produce the halogen substituted aryl nitrile.

专利号:EP-0882012-B1
优先权日:1995-12-28
标题 :Method for synthesis of an aromatic derivative substituted by a halogen atom other than fluorine and by a cyano group