CAS: 124752-23-4; Tert-Butyl (4R-Cis)-6-Formaldehydel-2,2-Dimethyl-1,3-Dioxane-4-Acetate

上下游产品

CAS号124655-09-0 (4R-Cis)-6-羟甲基-... | CAS号79-37-8 草酰氯 | CAS号540-88-5 醋酸叔丁酯 | CAS号124655-06-7 (5S)-6-(tert-bu... | CAS号147489-01-8 isopropyl (2S,3... | CAS号147488-99-1 isopropyl (2S,3... | CAS号289042-12-2 6-[(1E)-2-[4-(4... | CAS号124655-09-0 (4R-Cis)-6-羟甲基-... | CAS号147489-06-3 6-[[(1E)-2-环丙基-...

Tert-Butyl 2-((4R,6S)-6-((Tert-Butyldiphenylsilyloxy)Methyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate置于四丁基氟化铵体系中,用 四氢呋喃 用作溶剂,化学反应 3.0H,反应生成(4R-Cis)-6-醛基-2,2-二甲基-1,3-二氧己环-4-乙酸叔丁酯
参考文献:新型高效hmg-Coa还原酶抑制剂hr 780的立体选择性合成
标题:新型高效hmg-Coa还原酶抑制剂hr 780的立体选择性合成
摘要:Hr 780(1)是一种新的hmg-Coa还原酶抑制剂,是从l-苹果酸开始立体选择性合成的.研发了使用卤化nate,膦酸酯和膦氧化物的维蒂希烯化.
Doi:10.1016/0040-4039(90)80121-2

专利信息

专利号:WO-2014203045-A1
优先权日:2013-06-20
标 题:A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
发明人：ROY BHAIRABNATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG; PISE VIJAY SADASHIV; RUPANWAR MANOJ
权利人:LUPIN LTD
摘要:The present invention provides a process of preparation of an intermediate useful for the preparation of statins more particularly the present invention relates to an eco-friendly and cost effective process for the preparation of tert -butyl (3R,5S)-6-oxo-3,5-dihydroxy- 3,5-O-isopropylidene-hexanoate [I].

专利号:US-11814355-B2
优先权日:2020-08-06
标 题 :Method for synthesizing pitavastatin t-butyl ester
发明人：HUANG HUAN; LI KAI; HUANG QINGYUN; ZHAN FUMING; HUANG QINGGUO
权利人:ANHUI QINGYUN PHARMACEUTICAL AND CHEMICAL CO LTD
摘要:A method for synthesizing pitavastatin tert-butyl ester includes obtaining a substance B through reacting (4R-CIS)-6-chloromethyl-2,2-dimethyl-1,3-dioxolane-4-acetic acid tert-butyl ester with a substance A under the action of a first base catalyst, 5 oxidizing with an oxidizing agent to obtain a substance C, then reacting with 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-formaldehyde under the action of a second base catalyst to obtain a substance D, and finally, carrying out an acid deprotection to obtain pitavastatin t-butyl ester. The reaction conditions of the present invention are mild and controllable, and the reaction conditions of the synthesis of the Julia olefination do 10 not require an ultra-low temperature reaction. The operation is convenient and simple, the stereoselectivity is good, the yield is high, and the synthesized pitavastatin t-butyl ester is a completely non-cis isomer, and its purity is high.