CAS: 1211443-61-6; 2-Chloro-7-Cyclopentyl-N,N-Dimethyl-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide

上下游产品

2-氯-7-环戊基-7H-吡咯并[2,3-D]嘧啶-6-甲醇 (2-Chloro-7-Cyclopentyl-7H-Pyrrolo[2,3-D]Pyrimidin-6-yl)Methanol 1374639-77-6
2-Chloro-7-Cyclopentyl-6-(Diethoxymethyl)-7H-Pyrrolo[2,3-D]Pyrimidine 1211442-89-5

2-氯-7-环戊基-7H-吡咯并[2,3-D]嘧啶-6-甲醛置于oxone,O-(1H-Benzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Hexafluorophosphate,N,N-二异丙基乙胺体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 6.0H,反应生成2-氯-7-环戊基-N,N-二甲基-7H-吡咯并[2,3-D]嘧啶-6-甲酰胺
参考文献:Cdk9抑制剂及其制备方法与应用
标题:Cdk9抑制剂及其制备方法与应用
摘要:本申请提供了一种cdk9抑制剂,Cdk9抑制剂为嘧啶并吡咯类激酶抑制剂,且化学结构通式如式i所示:Cdk9抑制剂为嘧啶并吡咯类激酶抑制剂,该嘧啶并吡咯类激酶所适应的蛋白靶点是丝氨酸/苏氨酸激酶cdk9,该cdk9抑制剂表现出较高的特异性以及较低的细胞毒性,提供了一种用于预防或治疗肿瘤生长与转移的对cdk9具有选择性的,毒副效果小,作用效果强的cdk9抑制剂,从而通过该抑制剂调控cdk9的生物学功能,抑制肿瘤的生长,增殖过程.

专利信息

专利号:US-10336763-B1
优先权日:2018-05-17
标题:Crystal form B of ribociclib succinate
发明人：KAMANI SATYANARAYANA; LU TZU-CHIANG; CHANG HSIN-YUN; MAI CHIN-CHENG
权利人:CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:The present invention relates to crystal forms B, C and D of Ribociclib succinate salt and derivatives thereof, and their preparation method and composition. The crystal forms B, C and D of Ribociclib succinate salts are obtained by adding 7-cyclopentyl-N,N-dimethyl-2-(5-(piperain-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide solution into succinic acid solution for reaction, stirring the solution under high temperature, filtering the solution after cooling off.

专利号:WO-2023071314-A1
优先权日:2021-10-29
标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound