CAS: 110-94-1; Glutaric Acid

相似化合物

111-29-5 818-38-2 4221-03-8

上下游产品

CAS号13246-39-4 1-(三甲基硅基)乙醇 | CAS号53715-97-2 5,5'-氧双(5-氧代戊酸) | CAS号111-29-5 1,5-戊二醇 | CAS号96-41-3 环戊醇 | CAS号120-92-3 环戊酮 | CAS号142-29-0 环戊烯 | CAS号675-20-7 2-氮己环酮 | CAS号544-13-8 戊二腈 | CAS号142-68-7 四氢吡喃 | CAS号5057-98-7 顺式-1,2-环戊二醇 | CAS号43052-39-7 戊二酸二叔丁酯 | CAS号542-28-9 δ-戊内酯 | CAS号627-93-0 己二酸二甲酯 | CAS号4547-43-7 6-羟基己酸甲酯 | CAS号1119-40-0 戊二酸二甲酯 | CAS号14273-92-8 5-羟基戊酸甲酯 | CAS号931-17-9 1,2-环己二醇 | CAS号106-65-0 琥珀酸二甲酯 | CAS号3637-14-7 5-羰基辛酸 | CAS号2873-74-7 戊二酰氯

戊二腈置于sodium Hydroxide体系中,用 乙醇,水 用作溶剂,化学反应 12.0H,以61%的收率获得戊二酸
参考文献:1,4,6,8-四甲基[ 13 C 2 ] Azulene的同位素异构体混合物的合成及其与乙炔二甲酸二甲酯的热反应
标题:1,4,6,8-四甲基[ 13 C 2 ] Azulene的同位素异构体混合物的合成及其与乙炔二甲酸二甲酯的热反应
摘要:由相应的标记的[ 13 C 2 ]环戊二烯制备四氢呋喃(thf)中的[1,3-13 C 2 ]环戊二烯酸钠,由相应的标记物由13 Co 2和(氯甲基)三甲基硅烷合成(参见方案10),根据既定程序.它可以表明的乙酸热解顺式-环戊烷-1,2-二基二乙酸酯(顺式-22)在550+/-5°下减压(60托),得到5倍的环戊二烯如反式-22.钠[1,3-13 C 2]环戊二烯与thf中的2,4,6-三甲基四氟硼酸吡啶鎓导致形成统计上预期的4,6,8-三甲基[1,3A-13 C 2 ],-[2,3A] 2:2:1混合物-13 ç 2 ]-,以及-[1,3-13 ç 2 ]薁(20 ;参见方案7和图1).2:2:1混合物[ 13 C 2 ]-20的甲酰化和还原导致形成1,4,6,8-四甲基[1,3-13 ]的1:1:1:1:1混合物c 2 ]-,-[1,3A-13 C 2 ]-,-[2
Doi:10.1002/hlca.19950780604

专利信息

专利号:US-7928223-B2
优先权日:2008-06-20
标题:Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n n n n n n n n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8927708-B2
优先权日:2013-03-26
标 题 :Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine
发明人：LE FLOHIC ALEXANDRE
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nwherein R represents a para-methoxybenzyl (PMB) group or the following group:n n nApplication in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-8779122-B2
优先权日:2012-11-08
标 题:Process for the synthesis of (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8779123-B2
优先权日:2012-12-06
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8779121-B2
优先权日:2012-10-12
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.