CAS: 97207-47-1; 1-Methyl-[3,3'-Biindolinylidene]-2,2'-Dione

该化合物是一种合成有机化合物,以其独特的蓝色颜色闻名,被归类为异种衍生物.它主要在纺织业用作一种染料,类似于传统的异种,但具有强化特性,如光速和干燥性.Meisoindigo 的化学结构具有芳香环的复杂安排,有助于其稳定性和颜色特性.它通常在水中溶解,但可以溶解于有机溶剂,从而适合各种染色过程.此外,Meisoindigo因其电子特性而在有机电子和光精方面引起了兴趣.安全数据表明,与许多合成染料一样,应该谨慎处理,以避免潜在的皮肤刺激或环境影响.总的来说,Meisoindigo代表着染料技术的重大进步,将美学吸引力与各种应用的功能性能结合起来.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号59-48-3 2-吲哚酮 | CAS号2058-74-4 1-甲基靛红 | CAS号91-56-5 靛红

合成工艺路线路线简述

  • 2058-74-4 + 59-48-3 = 97207-47-1
    反应条件:1.1 Reagents: Acetic Acid Catalysts: Hydrochloric Acid; Overnight,Reflux
    标题:Design,Synthesis And Biological Evaluation Of N-Alkyl Or Aryl Substituted Isoindigo Derivatives As Potential Dual Cyclin-Dependent Kinase 2 (Cdk2)/glycogen Synthase Kinase 3β (Gsk-3β) Phosphorylation Inhibitors
    作者:Zhao,Ping; Li,Yanzhong; Gao,Guangwei; Wang,Shuai; Yan,Yun; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2014 卷标:86 页码:165-174]

    = 97207-47-1 [标题:Reaction Conditions
    标题:Potential Antileukemic Agents. Synthesis Of Derivatives Of Indirubin,Indigo,And Isoindigotin
    作者:Wu,Kemei; Zhang,Manyun; Fang,Zheng; Huang,Liang
    参考文献:Yaoxue Xuebao 日期:1985 卷标:20(11) 页码:821-6]

    = 97207-47-1 [标题:Reaction Conditions
    标题:Bisindolinones As Antitumor Agents
    参考文献:Japan]

    2058-74-4 + 16990-73-1 = 97207-47-1
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetic Acid; Rt -> 80 °C; 2 H,70 - 80 °C
    标题:Compositions And Methods To Improve The Therapeutic Benefit Of Indirubin And Analogs Thereof,Including Meisoindigo
    参考文献:United States]

    2058-74-4 + 59-48-3 = 97207-47-1
    反应条件:1.1 Catalysts: Hydrochloric Acid Solvents: Acetic Acid,Water; 30 Min,200 °C
    标题:Synthesis And Evaluation Of Functionalized Isoindigos As Antiproliferative Agents
    作者:Wee,Xi Kai; Yeo,Wee Kiang; Zhang,Bing; Tan,Vincent B. C.; Lim,Kian Meng; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2009 卷标:17(21) 页码:7562-7571]

    2058-74-4 + 59-48-3 = 97207-47-1
    反应条件:1.1 Rt1.2 Acidified
    标题:A Process For The Preparation Of Meisoindigo
    参考文献:World Intellectual Property Organization]

    16990-73-1 + 51079-13-1 = 97207-47-1
    反应条件:1.1 Reagents: Acetic Acid,Hydrochloric Acid Solvents: Water; 2 H,70 - 80 °C
    标题:Compositions And Methods To Improve The Therapeutic Benefit Of Indirubin And Analogs,Including Meisoindigo
    参考文献:World Intellectual Property Organization]

    = 97207-47-1 [标题:Reaction Conditions
    标题:Derivatives Of Isoindigo,Indigo And Indirubin And Use In Treating Cancer
    参考文献:World Intellectual Property Organization
📜(E)-1-(4-Methoxybenzyl)-1'-Methyl-[3,3'-Biindolinylidene]-2,2'-Dione 以85的收率获得产物甲异靛
参考文献:Adv. Synth. Catal. 2016,358,3534-3540
标题:Adv. Synth. Catal. 2016,358,3534-3540

海关参考信息

专利信息


专利号:CN-114644584-A
优先权日:2022-04-19
标 题 :A method for photocatalytic synthesis of 3,3'-disubstituted indol-2-ones without the participation of photosensitizers

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主要参考文献


1: Zhang ZX, Li SY, Li FF, Shi QY, Tan CY, Wang XJ, Li M, Liu YB, Jin J, Li Y, Yu SS. Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy. Adv Sci (Weinh). 2025 Jun;12(21):e2413676. doi: 10.1002/advs.202413676. Epub 2025 Apr 25.
2: Xiao Z, Hao Y, Liu B, Qian L. Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China. Leuk Lymphoma. 2002 Sep;43(9):1763-8. doi: 10.1080/1042819021000006295.
13:553. doi: 10.3389/fncel.2019.00553.

合成参考文献


参考文献:10.1016/j.ejmech.2014.08.049
摘要:Zhao P, Li Y, Gao G, Wang S, Yan Y, Zhan X, Liu Z, Mao Z, Chen S, Wang L. Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3β (GSK-3β) phosphorylation inhibitors. European Journal of Medicinal Chemistry. 2014 Oct;86():165–74. doi: 10.1016/j.ejmech.2014.08.049.
参考文献:10.1055/a-1784-2304
摘要:Meesin J, Chotsaeng N, Kuhakarn C. Dimerization of 3-Chlorooxindoles Mediated by Potassium Ethylxanthate: Synthesis of Isoindigos. Synlett. 2022 Mar 22;33(14):1317–22. doi: 10.1055/a-1784-2304.
参考文献:10.1007/s11082-023-05031-0
摘要:Zarif FA, Esmaeili AA, Zeraatkar Z, Behrouz M, Dehghani Z, Miccio LA, Sharifi S. Nonlinear optical properties of 3,3′-biindole 2,2′(1H,1′H)-dione derivatives. Opt Quant Electron. 2023 Jun 28;55(9). doi: 10.1007/s11082-023-05031-0.
参考文献:10.1134/s1068162025600850
摘要:Kaur G, Utreja D, Kalia A, Kaur S, Suneja Y. Synthesis and Biological Evaluation of N-1 Alkylated Isoindigo Derivatives: Antimicrobial, Antinematicidal, and Acetylcholinesterase Inhibition for Agrochemical Application. Russ J Bioorg Chem. 2025 Dec;51(6):2636–51. doi: 10.1134/s1068162025600850.
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