CAS: 969-99-3; Oxychlorpromazine

该化合物是氯丙诺明的氧化产物,一种具有显著药理意义的苯并呋喃衍生物,主要被确认为通过生物系统中的硫氧化物形成的氯丙诺胺的主要代谢物,该化合物具有独特的化学特性,包括极性和稳定性,这对分析和研究应用很有价值.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号50-53-3 氯丙嗪 | CAS号130-61-0 盐酸硫利达嗪 | CAS号69-09-0 盐酸氯丙嗪 | CAS号109-54-6 3-氯-1-(N,N-二甲基)丙胺 | CAS号50-53-3 氯丙嗪

合成工艺路线路线简述

  • 69-09-0 = 969-99-3
    反应条件:1.1 Reagents: Oxygen Catalysts: Nitrous Acid Solvents: Acetonitrile1.2 Solvents: Dichloromethane
    标题:Catalytic Oxidation Of Chlorpromazine And Related Phenothiazines. Cation Radicals As The Reactive Intermediates In Sulfoxide Formation
    作者:Bosch,Eric; Kochi,Jay K.
    参考文献:Journal Of The Chemical Society 日期:1995 卷标:(1995) 页码:1057-64]

    69-09-0 = 969-99-3
    反应条件:1.1 Reagents: 3-Fluoro-3-(1,1,2,2,3,3,3-Heptafluoropropyl)-2-(1,1,2,2,3,3,4,4,4-Nonafluorobuty... Solvents: 2,2,2-Trifluoroethanol
    标题:Oxaziridine,3-Fluoro-3-(Heptafluoropropyl)-2-(Nonafluorobutyl)
    作者:Metrangolo,Pierangelo; Novo,Barbara; Resnati,Giuseppe
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2005 页码:1-7]

    50-53-3 = 969-99-3
    反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Water
    标题:Convenient Oxidation Of Phenothiazine Salts To Their Sulfoxides With Aqueous Nitrous Acid
    作者:Owens,Margart L.; Juenge,Eric C.; Poklis,Alphonse
    参考文献:Journal Of Pharmaceutical Sciences 日期:1989 卷标:78(4) 页码:334-6]

    69-09-0 = 969-99-3
    反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Chloroform; Overnight,0 °C1.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Chemical Modifications Of N,N-Dimethylalkylamino-Substituted 2-Chlorophenothiazine And Their Electrochemical Behavior
    作者:Hayashi,Hideki; Ogawa,Tadashi; Koizumi,Take-Aki
    参考文献:Heterocycles 日期:2022 卷标:104(4) 页码:689-706]

    50-53-3 = 969-99-3
    反应条件:1.1 Reagents: Oxygen Catalysts: Ferric Nitrate Solvents: Acetic Acid; 3 H,Rt
    标题:Gram-Scale Synthesis Of Sulfoxides Via Oxygen Enabled By Fe(No3)3.9H2O
    作者:Liu,Kai; Meng,Jiaolong; Jiang,Xuefeng
    参考文献:Organic Process Research & Development 日期:2023 卷标:27(7) 页码:1198-1202]

    69-09-0 = 969-99-3 [标题:Reaction Conditions
    标题:Determination Of Iron(Ii) In Pharmaceuticals Using Chlorpromazine Hydrochloride As A Redox Indicator
    作者:Al-Rikabi,A. M. K.; Al-Jabri,F. M.; Hasoon,S. J.
    参考文献:Analytical Letters 日期:1989 卷标:22(15) 页码:3003-9]

    50-53-3 = 969-99-3 [标题:Reaction Conditions
    标题:The Determination Of Chlorpromazine,Related Impurities And Degradation Products In Pharmaceutical Dosage Forms
    作者:Chagonda,Lameck F. S.; Millership,Jeffrey S.
    参考文献:Journal Of Pharmaceutical And Biomedical Analysis 日期:1989 卷标:7(3) 页码:271-8]

    = 969-99-3 [标题:Reaction Conditions
    标题:Studies On Phenothiazines. Part 2. Synthesis Of Several N-10-Substituted Phenothiazine Sulfoxides And Their Spectroscopic Characteristics
    作者:Kreyenbuehl,B.; Joshi,R. K.; Perlia,X.
    参考文献:Pharmaceutica Acta Helvetiae 日期:1978 卷标:53(8) 页码:248-52]

    50-53-3 = 969-99-3 + 1672-76-0
    反应条件:1.1 Reagents: M-Chloroperbenzoic Acid,Sodium Hydroxide Solvents: Dichloromethane,Water; 0 °C; 4 H,0 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 10
    标题:Synthesis And Synergistic Antimycobacterial Screening Of Chlorpromazine And Its Metabolites
    作者:Kigondu,Elizabeth M.; Njoroge,Mathew; Singh,Kawaljit; Njuguna,Nicholas; Warner,Digby F.; Et Al
    参考文献:Medchemcomm 日期:2014 卷标:5(4) 页码:502-506]

    50-53-3 = 969-99-3
    反应条件:1.1 Reagents: Acetic Acid,Oxygen Catalysts: Ferric Nitrate; 3 H,Rt
    标题:Preparation Of Sulfoxide Compound From Thioether By Catalytic Oxidation
    参考文献:China]

    69-09-0 = 969-99-3
    反应条件:1.1 Reagents: Peroxyadipic Acid Solvents: Water; 15 Min,Rt
    标题:A Comparative Study Of The Effect Of Phenothiazine Derivatives And Their S-Oxides On Cholinesterase Investigated By A New Kinetic Spectrophotometric Method
    作者:Kovalenko,V. S.; Blazheyevskiy,M. Ye.; Merzlikin,S. I.
    参考文献:Zhurnal Organichnoi Ta Farmatsevtichnoi Khimii 日期:2022 卷标:20(1) 页码:35-43]

    69-09-0 = 969-99-3
    反应条件:1.1 Reagents: Perchloric Acid Catalysts: (Oc-6-11)-Hexachloroiridate(2-) Solvents: Water; 48 H,Rt
    标题:Spectrophotometric Kinetic And Mechanistic Investigation Of Chlorpromazine Radical Cation With Hexachloroiridate (Iv) In Catalyzed Aqueous Acid Medium
    作者:Sailani,Riya
    参考文献:Chemistryselect 日期:2021 卷标:6(33) 页码:8472-8479]

    69-09-0 = 969-99-3
    反应条件:1.1 Reagents: Potassium Peroxymonosulfate Solvents: Water; 20 °C
    标题:Spectrophotometric Determination Of Chlorpromazine Hydrochloride As Its Sulfoxide Obtained With Peroxymonosufate
    作者:Shlusar,O. I.; Blazheevskiy,M. Ye.
    参考文献:Visnik Farmatsii 日期:2012 卷标:(1) 页码:51-53]

    50-53-3 = 969-99-3
    反应条件:1.1 Catalysts: 3-Fluoro-3-(1,1,2,2,3,3,3-Heptafluoropropyl)-2-(1,1,2,2,3,3,4,4,4-Nonafluorobuty... Solvents: Trichlorofluoromethane
    标题:Oxaziridine,3-Fluoro-3-(Heptafluoropropyl)-2-(Nonafluorobutyl)-
    作者:Metrangolo,Pierangelo; Novo,Barbara; Resnati,Giuseppe
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001]

    = 969-99-3 [标题:Reaction Conditions
    标题:Laser Irradiated Phenothiazines: New Potential Treatment For Covid-19 Explored By Molecular Docking
    作者:Udrea,Ana-Maria; Avram,Speranta; Nistorescu,Simona; Pascu,Mihail-Lucian; Romanitan,Mihaela Oana
    参考文献:Journal Of Photochemistry And Photobiology 日期:2020 卷标:(2020)]

    = 969-99-3 [标题:Reaction Conditions
    标题:Preparative Microfluidic Electrosynthesis Of Drug Metabolites
    作者:Stalder,Romain; Roth,Gregory P.
    参考文献:Acs Medicinal Chemistry Letters 日期:2013 卷标:4(11) 页码:1119-1123]

    = 969-99-3 [标题:Reaction Conditions
    标题:Main Contribution Of The Cytochrome P450 Isoenzyme 1A2 (Cyp1A2) To N-Demethylation And 5-Sulfoxidation Of The Phenothiazine Neuroleptic Chlorpromazine In Human Liver-A Comparison With Other Phenothiazines
    作者:Wojcikowski,Jacek; Boksa,Jan; Daniel,Wladyslawa A.
    参考文献:Biochemical Pharmacology 日期:2010 卷标:80(8) 页码:1252-1259]

    = 969-99-3 [标题:Reaction Conditions
    标题:Use Of Ultraviolet Spectroscopy To Detect Phenothiazine Derivatives In Chemical And Toxicological Studies Of Biological Material
    作者:Salomatin,E. M.
    参考文献:Farmatsiya (Moscow 日期:1987 卷标:36(5) 页码:34-40]

    = 969-99-3 [标题:Reaction Conditions
    标题:Studies On The Effect Of Chlorpromazine And Its Derivatives On Locomotor Activity In Mice
    作者:Horng,Tzyy Show; Lin,Jen Kun
    参考文献:Taiwan Yaoxue Zazhi 日期:1983 卷标:35(2) 页码:190-7]

    50-53-3 = 969-99-3 + 2095-62-7 + 3926-66-7 + 3930-47-0
    反应条件:1.1 Reagents: L-Ascorbic Acid,Acetic Acid,Sodium Acetate,Trisodium Edta,Manganese Diacetate,Oxygen,Ferrous Sulfate Heptahydrate Solvents: Water; 2 H,Ph 4,45 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8.5
    标题:Synthesis Of Potential Drug Metabolites By A Modified Udenfriend Reaction
    作者:Slavik,Roger; Peters,Jens-Uwe; Giger,Rudolf; Buerkler,Markus; Bald,Eric
    参考文献:Tetrahedron Letters 日期:2011 卷标:52(7) 页码:749-752
📜盐酸氯丙嗪置于高氯酸,Pentaaqua Iron(Iv) Oxo Complex体系中,化学反应生成 氧氯丙嗪
参考文献:铁(iv)-氧代络合物的电子转移反应性.外球与质子耦合电子转移
标题:铁(iv)-氧代络合物的电子转移反应性.外球与质子耦合电子转移
摘要:报道了铁(iv)水溶液fe Iv(H2O)5 O 2+(以下称fe Iv Aq O 2+)氧化有机和无机还原剂的动力学.检查的底物包括几种水溶性二茂铁,六氯铱酸盐(iii),聚吡啶基配合物m(nn)3 2+(m = Os,Fe和ru; Nn =菲咯啉,联吡啶和衍生物),Habts-/ Abts 2-和吩噻嗪,Co Ii(dmgbf 2)2,大环镍(II)配合物和铈水溶液(iii).除吩噻嗪在一步反应中反应生成相应的氧化物以及反应生成配体的fe(II)和ru(II)的多吡啶基配合物外,大多数还原剂均被干净地氧化为相应的单电子氧化产物.改性产品.fe Iv Aq O 2+甚至可以以大于10 4 M-1 S-1的速率常数甚至氧化ce(iii)(1 M Hclo 4中的e 0 = 1.7 V).在25oc的0.10 M Hclo 4水溶液中,Os(phen)3 2+(k = 2.5x10 5出现m
DOI:10.1021/acs.Inorgchem.6B00966

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2: Li X, Yang Y, Zhou K. [Simultaneous determination of chlorpromazine and promethazine and their main metabolites by capillary electrophoresis with electrochemiluminescence]. Se Pu. 2012 Sep;30(9):938-42. Chinese. doi: 10.3724/sp.j.1123.2012.04025. 123(3):247-52. doi: 10.1007/s00414-008-0304-9. Epub 2008 Dec 2. 51(4):217-22. doi: 10.1111/j.1440-1819.1997.tb02586.x. 227(2):368-73. doi: 10.1006/bbrc.1996.1514. 9(7):845-9. doi: 10.1023/a:1015880327911. 16(2):97-104. doi: 10.1016/0305-4179(90)90165-s. 50(5):659-64. doi: 10.1111/j.1751-1097.1989.tb04323.x. 38(20):3593-9. doi: 10.1016/0006-2952(89)90132-9. 48(5):621-6. doi: 10.1111/j.1751-1097.1988.tb02872.x. 245(3):823-8. 437(2):397-401. doi: 10.1016/0006-8993(87)91660-x. 26(25):8133-7. doi: 10.1021/bi00399a017. 76(10):803-8. doi: 10.1002/jps.2600761011. 9(3):358-65. 333(4):454-6. doi: 10.1007/BF00500024. 44(1):5-10. doi: 10.1111/j.1751-1097.1986.tb03556.x. 8(1):37-41. 110(9):1117-24. doi: 10.1039/an9851001117. 130(3):952-6. doi: 10.1016/0006-291x(85)91707-3. 27(3):387-93. 7(4):472-7. doi: 10.1097/00007691-198512000-00020. 7(2):222-8. doi: 10.1097/00007691-198506000-00015. 226(3):833-8. 273(2):384-6. doi: 10.1016/0006-8993(83)90868-5. 140(1):49-52. doi: 10.1016/0014-5793(82)80518-8. 21(2):409-14.
80:199-204. doi: 10.1002/cm.970020738. 27(1):55-61.

合成参考文献


摘要:Folgueiras-Amador, A. A.; Wirth, T., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 166.
摘要:Journal of Pharmacology and Experimental Therapeutics., 118(328), 1956 []
摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
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