CAS: 885276-93-7; Ethyl 5-Bromopyrazolo[1,5-A]Pyridine-3-Carboxylate

该化合物是一种化学化合物,其特点是其独特的pyrazolo-pyridine结构,其特点是一个包括pyrazole和pyridine moices的引信环系统.该化合物通常具有与七环化合物有关的特性,例如潜在的生物活动,使其对药用化学感兴趣.在环的5位置上存在溴原子,可以影响其再活性和溶性,而乙酯组则能够加强其脂性,有可能改进其药用植物特性.该碳箱酸功能允许进一步进行化学修改,这可能有助于药物开发.此外,这种性质的化合物可能显示出各种生物活动,包括反炎或抗微生物特性,尽管具体的生物数据将取决于经验研究.总的来说,该化合物是一种用于进一步化学探索和潜在治疗用途的多功能.

结构式图片

相似化合物

1101121-05-4 1101120-53-9 1352897-20-1

物理性质

MSDS等安全信息

上下游产品

CAS号623-47-2 丙炔酸乙酯 | CAS号1101120-33-5 5-[(叔丁氧羰基)氨基]吡唑... | CAS号98400-69-2 4-(叔丁氧羰基氨基)吡啶 | CAS号1101121-05-4 5-溴吡唑并[1,5-a]吡啶-3-羧酸

合成工艺路线路线简述

  • 合成目标产物 5-Bromo-Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid Ethyl Ester 主要起始原料 1-Amino-4-Bromopyridinium Iodide And Ethyl Propiolate
  • 4637-24-5 + 1060814-91-6 = 885276-93-7
    反应条件:1.1 Overnight,50 °C; 50 °C -> Rt1.2 Reagents: Azanyl 2,4,6-Trimethylbenzenesulfonate Solvents: Dichloromethane; 1 H,0 °C
    标题:Divergent And Regioselective Synthesis Of Pyrazolo[1,5-A]Pyridines And Imidazo[1,5-A]Pyridines
    作者:Mennie,Katrina M.; Reutershan,Michael H.; White,Catherine; Adams,Bruce; Becker,Bridget; Et Al
    参考文献:Organic Letters 日期:2021 卷标:23(12) 页码:4694-4698]

    1101120-35-7 = 885276-93-7
    反应条件:1.1 Reagents: Sodium Nitrite,Hydrogen Bromide Solvents: Water; 5 Min,0 °C; 10 Min,0 °C1.2 Reagents: Copper Bromide (Cubr),Hydrogen Bromide Solvents: Water; 0 °C; 0 °C -> 50 °C; 15 Min,50 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 5
    标题:Discovery Of Pyrazolo[1,5-A]Pyridines As P110α-Selective Pi3 Kinase Inhibitors
    作者:Kendall,Jackie D.; O'Connor,Patrick D.; Marshall,Andrew J.; Frederick,Raphael; Marshall,Elaine S.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2012 卷标:20(1) 页码:69-85
📜5-[(叔丁氧羰基)氨基]吡唑并[1,5-A]吡啶-3-羧酸乙酯置于氢溴酸,Sodium Nitrite体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 18.45H,反应生成 5-溴吡唑并[1,5-A]吡啶-3-羧酸乙酯
参考文献: Pyrazolo[1,5-A]Pyridines And Their Use In Cancer Therapy[fr] Pyrazolo[1,5-A]Pyridines Et Leur Utilisation En Cancérothérapie
标题: Pyrazolo[1,5-A]Pyridines And Their Use In Cancer Therapy[fr] Pyrazolo[1,5-A]Pyridines Et Leur Utilisation En Cancérothérapie
摘要:Pyrazolo[1,5-A]吡啶类化合物被描述,包括它们的制备方法,以及它们作为抗癌治疗药物或药剂的用途,无论是单独使用还是与放疗和/或其他抗癌药物联合使用.

海关参考信息

专利信息


专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis

专利号:EP-3083583-B1
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:EP-3083583-A1
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CA-2934251-C
优先权日:2013-12-20
标 题:A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer

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