CAS: 850663-54-6; 4-Chloro-5-Nitropyridin-2(1H)-One

该化合物是一种环环生物化合物,其特点是用氯原子和硝基化合物组以及一个氢氧基组来替代一个环形环状环状物;该化合物一般呈现黄色至褐色的灰色外观,并且由于存在氢氧化物组,可溶于极地溶剂中,可进行氢联结;氯和硝化亚化物替代体有助于其反应,成为各种化学反应的候选产品,包括核阴性替代物和电阴性代用品;电镀组(氯和氮基)的存在可影响化合物的酸度和基本性及其总体稳定性;此外,4-氯-5-硝基罗苯丁-2-醇可能因其独特的结构特征,在制药,农业化学品或有机合成中作为中间体中应用.在处理时,应参考安全数据,因为与硝基混合物的化合物可能具有敏感性和潜在危险性.

英文名称4-Chloro-5-Nitropyridin-2(1H)-One
中文名称2-羟基-4-氯-5-硝基吡啶
IUPAC名称4-chloro-5-nitropyridin-2(1H)-one
其它别名4-Chloro-5-Nitropyridin-2(1H)-One; 4-Chloro-5-Nitropyridin-2-Ol; 4-Chloro-2-Hydroxy-5-Nitropyridine; 4-Chloro-5-Nitro-1H-Pyridin-2-One; 4-Chloro-5-Nitro-Pyridin-2-Ol; 4-Chloro-5-Nitro-2-Hydroxypyridine; 2(1H)-Pyridinone, 4-Chloro-5-Nitr
CAS编号850663-54-6
MFCD编号:MFCD11046303
EINECS号:811-556-6
分子式:C5H3ClN2O3
分子量:174.54
产品CID: 1843850
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: VZBXTOUZMQUTIQ-UHFFFAOYSA-N
InChI=1S/C5H3ClN2O3/c6-3-1-5(9)7-2-4(3)8(10)11/h1-2H,(H,7,9)…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

相似化合物

165547-79-5 198268-98-3 22353-38-4

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

ECHA物质C&L通报

上下游产品

4-hydroxy-3-nitropyridine 2,4-dichloro-5-nitropyridine 4-(2-Fluoro-4-iodophenylamino)-5-nitropyridin-2(1H)-one 4-(2-Fluoro-4-bromophenylamino)-5-nitropyridin-2(1H)-one 4-(ethylamino)-5-nitro-2-phenoxy-pyridine

合成工艺路线路线简述

13091-23-1 = 850663-54-6
反应条件:1.1 Reagents: Potassium Tert-Butoxide,Ammonia Catalysts: Tert-Butyl Hydroperoxide Solvents: Tetrahydrofuran,Decane; -78 °C -> -35 °C; 5 Min,0 °C; 0 °C; 1.5 H,-35 °C1.2 Reagents: Ammonium Chloride Solvents: Water; 16 H,-35 °C -> Rt
标题:Design And Synthesis Of A Novel Series Of Cyclohexyloxy-Pyridyl Derivatives As Inhibitors Of Diacylglycerol Acyl Transferase 1
作者:Plowright,Alleyn T.; Barton,Peter; Bennett,Stuart; Birch,Alan M.; Birtles,Susan; Et Al
参考文献:Medchemcomm 日期:2013 卷标:4(1) 页码:151-158]

13091-23-1 = 850663-54-6
反应条件:1.1 Reagents: Potassium Tert-Butoxide,Ammonia Solvents: Tetrahydrofuran; -78 °C -> -35 °C1.2 Reagents: Tert-Butyl Hydroperoxide Solvents: Tetrahydrofuran; 0 °C1.3 Solvents: Tetrahydrofuran; 30 Min,-35 °C; 30 Min,-35 °C; -35 °C -> -78 °C1.4 Reagents: Ammonium Chloride Solvents: Water; -78 °C -> Rt
标题:Identification And Optimization Of Benzimidazole Sulfonamides As Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists With In Vivo Activity
作者:Hennessy,Edward J.; Oza,Vibha; Adam,Ammar; Byth,Kate; Castriotta,Lillian; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2015 卷标:58(17) 页码:7057-7075]

13091-23-1 = 850663-54-6
反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,Potassium Tert-Butoxide,Ammonia Solvents: Tetrahydrofuran
标题:Syntheses Of 4- And 6-Substituted Thiazolo[4,5-C]Pyridines
作者:Huang,Yuhua; Bennett,Frank; Girijavallabhan,Vinay; Alvarez,Carmen; Chan,Tze-Ming; Et Al
参考文献:Tetrahedron Letters 日期:2010 卷标:51(21) 页码:2800-2802]

13091-23-1 = 850663-54-6
反应条件:1.1 Solvents: Tetrahydrofuran; Rt -> -78 °C1.2 Reagents: Potassium Tert-Butoxide,Ammonia; -78 °C -> -35 °C1.3 Solvents: Tetrahydrofuran; Rt -> 0 °C1.4 Reagents: Tert-Butyl Hydroperoxide Solvents: Decane; 5 Min,0 °C1.5 1 H,-35 °C; 2 H,-35 °C1.6 Reagents: Ammonium Chloride Solvents: Water
标题:Discovery Of Aminofurazan-Azabenzimidazoles As Inhibitors Of Rho-Kinase With High Kinase Selectivity And Antihypertensive Activity
作者:Stavenger,Robert A.; Cui,Haifeng; Dowdell,Sarah E.; Franz,Robert G.; Gaitanopoulos,Dimitri E.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2007 卷标:50(1) 页码:2-5]

13091-23-1 = 850663-54-6
反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,Potassium Tert-Butoxide Solvents: Dimethylformamide,Decane; -35 °C; 2 H,-35 °C1.2 Reagents: Ammonium Chloride Solvents: Water; 30 Min,Rt1.3 Reagents: Potassium Carbonate Solvents: Water; Ph 8 - 9
标题:Novel 2,4,5-Trisubstituted Pyridines As Key Intermediates For The Preparation Of The Tspo Ligand 6-F-Pbr28: Synthesis And Full 1H And 13C Nmr Characterization
作者:Damont,Annelaure; Lemee,Frederic; Raggiri,Guillaume; Dolle,Frederic
参考文献:Journal Of Heterocyclic Chemistry 日期:2014 卷标:51(2) 页码:404-410

4-羟基-3-硝基吡啶置于叔丁基过氧化氢,五氯化磷,三氯氧磷体系中,用四氢呋喃,癸烷作为反应溶剂,化学反应 6.25H,反应生成 4-氯-2-羟基-5-硝基吡啶
参考文献:Novel Aromatic Compound And Use Thereof
标题:Novel Aromatic Compound And Use Thereof
摘要:提供的是一种显示促进骨形成作用(和/或抑制骨吸收作用)的化合物.具有以下结构的化合物(i)或药理学上可接受的盐:[其中每个取代基如描述中所定义],具有低毒性,显示非常好的药代动力学特性,具有促进骨形成的作用,并且对于预防或治疗代谢性骨疾病(骨质疏松症,纤维性骨炎(甲状旁腺功能亢进症),软骨软化症,帕吉特病等影响全身骨代谢参数的疾病)非常有用,这些疾病与骨形成能力下降相比骨吸收能力.