CAS: 80262-44-8; Cucurbituril

该化合物是一类以其独特的桶状结构为特征的大型循环化合物,其特点是银酸核聚变体的聚合体,这些化合物因其能够选择性地将客人的分子嵌入其腔内,使其在超分子化学和纳米技术中具有价值而值得注意;Cucurbituril表现出一种水分恐惧的内部和水利外表,使它们能与各种有机和无机的客人物种进行有利的互动;它们形成宿主-访客群的能力受到诸如客人分子大小和形状,以及周围环境的pH和ionic强度等因素的影响;此外,curitutrils可以参与各种化学反应,并正在探索用于药物的输送,感应和催化.CAS编号为80262-44-8的化合物具体指curitit[7,7,uril,这是这个家族中研究最多的成员之一,以其相对大的小的腔体大小和多功能结合特性著称.

结构式图片

相似化合物

259886-50-5 259886-51-6 259886-49-2

欧盟法规

ECHA物质C&L通报

上下游产品

Cucurbit[8]Uril

合成工艺路线路线简述

  • 合成目标产物 Cucurbituril 主要起始原料 Formaldehyde And Urea
  • 5395-50-6 = 80262-44-8
    反应条件:1.1 Reagents: Sulfuric Acid; Rt -> 120 °C; 120 °C -> Rt1.2 Reagents: Water; Cooled1.3 Reagents: Formic Acid Solvents: Water; 1 H,Rt -> Reflux
    标题:Catalytic Self-Threading: A New Route For The Synthesis Of Polyrotaxanes
    作者:Tuncel,Doenues; Et Al
    参考文献:Macromolecules 日期:2004 卷标:37(2) 页码:288-302]

    496-46-8 = 80262-44-8 + 259886-50-5 + 259886-49-2 + 259886-51-6
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; 24 H,75 - 90 °C
    标题:Cucurbituril Homologues And Derivatives: New Opportunities In Supramolecular Chemistry
    作者:Lee,Jae Wook; Et Al
    参考文献:Accounts Of Chemical Research 日期:2003 卷标:36(8) 页码:621-630]

    496-46-8 = 80262-44-8
    反应条件:1.1 Reagents: Aniline; 10 Min
    标题:Efficient Synthesis Of Cucurbiturils And Their Derivatives Using Mechanochemical High-Speed Ball Milling (Hsbm)
    作者:Xu,Wenhao; Et Al
    参考文献:High Performance Polymers 日期:2021 卷标:33(5) 页码:509-518]

    17464-89-0 = 80262-44-8
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 7 H,100 °C; 13 H,100 °C
    标题:Tetraacetoxymethyl Glycoluril As Precursor In The Preparation Of Cucurbit[6]Uril And New Oligomer
    作者:Arrous,Salah; Et Al
    参考文献:Research Journal Of Chemistry And Environment 日期:2019 卷标:23(9) 页码:1-4]

    107-22-2 + 57-13-6 = 80262-44-8
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 90 °C2.1 Reagents: Hydrochloric Acid,Sulfuric Acid Solvents: Water; 160 °C
    标题:Palladium Nanoparticles Supported On Cucurbit[6]Uril: An Efficient Heterogeneous Catalyst For The Suzuki Reaction Under Mild Conditions
    作者:Karami,K.; Et Al
    参考文献:Applied Organometallic Chemistry 日期:2015 卷标:29(1) 页码:33-39]

    496-46-8 = 80262-44-8 + 259886-51-6
    反应条件:1.1 Reagents: Toluene; 10 Min
    标题:Efficient Synthesis Of Cucurbiturils And Their Derivatives Using Mechanochemical High-Speed Ball Milling (Hsbm)
    作者:Xu,Wenhao; Et Al
    参考文献:High Performance Polymers 日期:2021 卷标:33(5) 页码:509-518]

    496-46-8 = 80262-44-8
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; Heated
    标题:Facile Purification Of Rare Cucurbiturils By Affinity Chromatography
    作者:Sasmal,Sanjita; Et Al
    参考文献:Organic Letters 日期:2004 卷标:6(8) 页码:1225-1228]

    496-46-8 = 80262-44-8 + 259886-50-5 + 259886-49-2
    反应条件:1.1 Reagents: Sodium Chloride; 10 Min
    标题:Efficient Synthesis Of Cucurbiturils And Their Derivatives Using Mechanochemical High-Speed Ball Milling (Hsbm)
    作者:Xu,Wenhao; Et Al
    参考文献:High Performance Polymers 日期:2021 卷标:33(5) 页码:509-518
1,6-己二胺 反应生成 葫芦脲 水合物
参考文献:Us2013/195751
标题:Us2013/195751

专利信息


专利号:US-8697134-B2
优先权日:2010-06-21
标题:Facile route to the synthesis of resorcinarene nanocapsules
发明人:BALASUBRAMANIAN RAMJEE; KALAITZIS ZAHAROULA M; PRAYAKARAO SRUJANA
权利人:BALASUBRAMANIAN RAMJEE; KALAITZIS ZAHAROULA M; PRAYAKARAO SRUJANA; OLD DOMINION UNIV RES FOUND
摘要:Described is a direct method for the fabrication of resorcinarene nanocapsules by photopolymerization of compounds of formula (I), such as resorcinarene tetraalkene tetrathiol (RTATT), in the absence of any template or preorganization. Further, by varying the polymerization media, a variety of other polymeric architectures like lattices, fibrous networks, and nanoparticles were obtained. The morphology and structure were characterized by transmission electron microscopy, energy dispersive spectroscopy, scanning electron microscopy, dynamic light scattering, infrared and nuclear magnetic resonance spectroscopy. These morphologically distinct resorcinarene polymeric architectures contain residual thiol and ene functional groups offering potential functionalization opportunities.

专利号:US-2012208780-A1
优先权日:2011-02-16
标 题:Hybrid nanomaterials consisting of pseudorotaxanes, pseudopolyrotaxanes, rotaxanes, polyrotaxanes, nanoparticles and quantum dots
发明人:ADELI MOHSEN; KALANTARI MAHDIEH; SAGVAND MAASOOMEH
权利人:ADELI MOHSEN; KALANTARI MAHDIEH; SAGVAND MAASOOMEH; LORESTAN UNIVERSITY
摘要:This invention provides the synthesis of biocompatible and high functional hybrid nanomaterials consisting of pseudorotaxanes, pseudopolyrotaxanes, rotaxanes, polyrotaxanes, nanoparticles and quantum dots (QDs). The molecular self-assembly of hybrid nanomaterials lead to the formation of nano-objects with different shapes such as core-shell, spindle-like or necklaces. Due to their well-defined molecular self-assemblies, carbohydrate backbone, high functionality and several types of functional groups together with the high luminescence yield, thermal and physical properties and synthesized hybrid nanostructures were recognized as promising candidates for a wide range of applications.

专利号:US-2024247311-A1
优先权日:2022-12-22
标题 :Palladium catalyst compositions and methods for sequencing by synthesis
发明人:PEDROSO CASSIO; PANIGRAHI ADYASHA; MARIANI ANGELICA; CARVER ADAM; HOURS RAPHAËLLE; CHANDRACHUD PREETI; FRANCAIS ANTOINE; APSUNDE TUSHAR; HATTINGH KATHRYN; BEECH TIMOTHY; SOLIS DANIEL; LAWRENCE ELLIOT J
权利人:ILLUMINA INC
摘要:The present application relates to palladium catalyst composition and uses in sequencing by synthesis. In particular, the Pd catalyst composition comprises one or more macrocycles (e.g., cyclodextrin or analogs thereof) as additives for improving thermal or oxidative stability of the active Pd(0) species.

专利号:CN-103214499-B
优先权日:2013-04-12
标 题:Transition metal-induced synthesis of Q[8]-alkali metal, alkaline earth metal ion coordination polymer and its synthesis method

专利号:US-11918657-B2
优先权日:2017-11-10
标 题 :Dendrimer delivery system and methods of use thereof
发明人:RANGARAMANUJAM KANNAN; SHARMA RISHI; SHARMA ANJALI; KANNAN SUJATHA; ZHANG ZHI; KAMBHAMPATI SIVA PRAMODH
权利人:UNIV JOHNS HOPKINS
摘要:Low-generation dendrimers containing a high density of surface hydroxyl groups, and methods of synthesis thereof are provided. In particular, oligo ethylene glycol (OEG)-like dendrimers with a high surface functional groups at relatively low generations (e.g. Ëœ120 hydroxyls in the third generation, with a size of just 1-2 nm) is described. Dendrimer formulations including one or more prophylactic, therapeutic, and/or diagnostic agents, and methods of use thereof are also described. The formulations are suitable for topical, enteral, and/or parenteral delivery for treating one or more diseases, conditions, and injuries in the eye, the brain and nervous system (CNS), particularly those associated with pathological activation of microglia and astrocytes.

专利号:WO-2023106291-A1
优先权日:2021-12-07
标题 :Production of protein crystal material
发明人:UENO TAKAFUMI; ABE SATOSHI; KOJIMA MARIKO; TANAKA JUNKO
权利人:TOKYO INST TECH
摘要:The present invention employs a method for producing protein crystals, said method including a step for incubating a crystallization solution containing a cell-free protein synthesis system, a crystallization control agent, and a nucleic acid encoding the protein.
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主要参考文献

[参考文献]: Chang-Feng Li, Et Al. Study On The Inclusion Interaction Of Cucurbit[参考文献]: Jeeyeon Kim, Et Al. Glyco-Pseudopolyrotaxanes: Carbohydrate Wheels Threaded On A Polymer String And Their Inhibition Of Bacterial Adhesion. Chemistry. 2010 Oct 25;16(40):12168-73.
[参考文献]: Li Liu, Et Al. Controlled Catch And Release Of Small Molecules With Cucurbit[参考文献]: Nan Zhao, Et Al. Binding Studies On Cb[参考文献]: Shonagh Walker, Et Al. Synthesis, Processing And Solid State Excipient Interactions Of Cucurbit[6]Uril And Its Formulation Into Tablets For Oral Drug Delivery. Mol Pharm. 2010 Dec 6;7(6):2166-72.

合成参考文献


参考文献:10.1021/la202120u
摘要:Porel M, Jockusch S, Ottaviani MF, Turro NJ, Ramamurthy V. Interaction between encapsulated excited organic molecules and free nitroxides: communication across a molecular wall. Langmuir. 2011 Sep 06;27(17):10548–55. doi: 10.1021/la202120u.
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