CAS: 775-16-6; 1-Benzyl-3-Pyrrolidinone

上下游产品

CAS号775-15-5 N-苄基-3-吡咯烷醇 | CAS号100-46-9 苄胺 | CAS号155622-69-8 1-溴-2-酮-3-丁烯 | CAS号107771-02-8 N-(2-Diaethylam... | CAS号86269-11-6 (Tributylstanny... | CAS号145090-28-4 3-氨基-1-苄基-3-氰基吡咯烷 | CAS号706-03-6 3-(苄氨基)丙腈 | CAS号101385-90-4 (S)-3-羟基-1-苄基吡咯烷 | CAS号101385-93-7 1-叔丁氧碳基-3-吡咯烷酮 | CAS号172477-98-4 2-Methyl-2-prop... | CAS号66832-28-8 N-(1-benzylpyrr... | CAS号912635-60-0 5-苄基-1,4,5,6-四氢... | CAS号96567-93-0 1-苄基-3-甲基吡咯烷-3-醇 | CAS号96568-35-3 1-苄基-3-(甲氨基)吡咯烷

N-苄基-3-吡咯烷醇置于草酰氯,二甲基亚砜,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.5H,以90.9%的收率获得产物1-苄基-3-吡咯烷酮
参考文献:一种5-苄基-5-N杂螺[2.4]庚烷-1-羧酸的制 备方法
标题:一种5-苄基-5-N杂螺[2.4]庚烷-1-羧酸的制 备方法
摘要:本发明公开了一种5‑苄基‑5‑n杂螺[2.4]庚烷‑1‑羧酸的制备方法,所述制备方法为:1‑苄基‑3‑羟基吡咯烷经过一系列斯文氧化反应,维蒂希反应,硫叶立德反应,水解反应最终制得所述5‑苄基‑5‑n杂螺[2.4]庚烷‑1‑羧酸.本发明方法利用双键与硫叶立德反应形成三元环,便宜易得的原料,温和的条件,简单的操作方式使得工业化的可能性大大增强.

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:CN-114369052-B
优先权日:2021-12-21
标题 :A kind of synthesis method of 3-aminopyrrolidine dihydrochloride

专利号:CN-1733720-A
优先权日:2005-08-25
标题 :Synthesis method of N-substituted-3-amidopyrrolidine and its bihydrochlorate

专利号:RU-2193030-C2
优先权日:1996-12-20
标题 :Nitrogen-containing heterocyclic compounds, method of their synthesis, pharmaceutical composition based on thereof and intermediate substances