CAS: 6779-87-9; 2-Amino-6-((1R,2S)-1,2-Dihydroxypropyl)-7,8-Dihydropteridin-4(1H)-One
该化合物是一种减少的L-比生素形式,在酶反应中,特别是在硝基氧化物和芳香氨基酸盐盐酸盐酸酸盐酸酸盐酸反应的生物合成中,是关键的共生因素,在细胞红氧化工艺和...
- 英文名称2-Amino-6-((1R,2S)-1,2-Dihydroxypropyl)-7,8-Dihydropteridin-4(1H)-One
- 中文名称7,8-二氢生物蝶呤
- IUPAC名称2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-7,8-dihydropteridin-4(1H)-one
- 其它别名7,8-Dihydrobiopterin; 7,8-Dihydro-L-Biopterin; 2-Amino-6-(1R,2S-Dihydroxypropyl)-7,8-Dihydro-4(1H)-Pteridinone; 1-(2-Amino-4-Hydroxy-7,8-Dihydropteridin-7-yl)Propane-1,2-Diol; Bh2; Dihydrobiopterin; 2-Amino-6-(1,2-Dihydroxy-Propyl)-7,8-Dihydro-3H-Pteridin-4-One; 2-Amino-6-[(1R,2S)-1,2-Dihydroxypropyl]-7,8-Dihydro-4(3H)-Pteridinone
- CAS编号6779-87-9
- MFCD编号:MFCD07375453
- FDA UNII编号:AYP47DS84P
- 分子式:C9H13N5O3分子量:239.24
- 产品CID: 1662332
- 产品分类生物化工 → 核酸类
物理性质
MSDS等安全信息
上下游产品
CAS号79647-29-3 (6R)-2-amino-6-... | CAS号712-30-1 2-氨基-4-氧代-3,4-二... | CAS号948-60-7 2-氨基-4-氧代-3,4-二... | CAS号22150-76-1 L-生物喋呤合成工艺路线路线简述
- 6779-87-9 = 6779-87-9 + 22150-76-1 + 948-60-7 + 712-30-1
反应条件:1.1 Reagents: Oxygen Solvents: Water
标题:Photochemistry Of Dihydrobiopterin In Aqueous Solution
作者:Vignoni,Mariana; Cabrerizo,Franco M.; Lorente,Carolina; Claparols,Catherine; Oliveros,Esther; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2010 卷标:8(4) 页码:800-810
📜(6R)-L-Erythro-5,6,7,8-Tetrahydrobiopterin置于氧气体系中,化学反应 60.0H,反应生成 7,8-二氢生物蝶呤
参考文献:还原酶催化的四氢生物蝶呤再生减轻了7,8-二氢生物蝶呤对酪氨酸羟基化的反竞争抑制作用
标题:还原酶催化的四氢生物蝶呤再生减轻了7,8-二氢生物蝶呤对酪氨酸羟基化的反竞争抑制作用
摘要:酪氨酸羟化酶使l-酪氨酸羟化是制备许多保健食品和药物的重要反应.在细菌中构建这些途径的两个主要挑战是羟化酶催化效率的提高和辅因子四氢生物蝶呤(bh4)的产生.在这项研究中,我们通过phyml和mafft分析了不同物种的酪氨酸羟化酶之间的进化关系和保守的蛋白质序列.最后,我们选择了7个酪氨酸羟化酶和6个sepaapterin还原酶.随后,通过组合的全细胞催化剂鉴定了不同基团的功能,并筛选了一系列新型的酪氨酸羟化酶/ Septapterin还原酶(th / Spr)合成系统,其中包括酪氨酸羟化酶(来自于streptosporangium Roseum)dsm 43021和thermomonospora Curvata Dsm 43183)和sepiapterin还原酶(从发光菌damselae,Chlorobaculum Thiosulfatiphilum和致病杆菌属poinarii),即作为srth
DOI:10.1039/d0Cy01958E
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905142000-仲丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11718864-B2
优先权日:2015-09-23
标 题 :Cells and method of cell culture
发明人：HILLER GREGORY WALTER; MITCHELL JEFFREY JOSEPH; MULUKUTLA BHANU CHANDRA; PEGMAN PAMELA MARY
权利人:PFIZER
摘要:The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.
专利号:US-5401844-A
优先权日:1983-04-11
标 题 :Regulation of enzymes which utilize tetrahydrobiopterin or tetrahydrofolate cofactors with 6,6-disubstituted-tetrahydropteridines
发明人：AYLING JUNE E; BAILEY STEVEN W
权利人:UNIV SOUTH ALABAMA
摘要:6-[2'-Amino-2',2'-disubstituted-ethylamino]-pyrimidines of the structure: ##STR1## in which X=H, NH 2 or NO 2 , which are novel intermediates in the synthesis of quinoid 6,6-disubstituted-dihydro- and 6,6-disubstituted-tetrahydro-pteridines, are claimed.
专利号:JP-H06316576-A
优先权日:1983-04-11
标题 :Synthesis of 6,6-di-substituted dihydropteridine
专利号:WO-9513803-A1
优先权日:1993-11-15
标题 :Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
专利号:CA-2075346-A1
优先权日:1991-12-26
标 题:Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
专利号:CA-2176143-A1
优先权日:1993-11-15
标题 :Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/s1385-299x(01)00081-2
摘要:Kaneko YS, Mori K, Nakashima A, Nagatsu I, Nagatsu T, Ota A. Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection. Brain Res Brain Res Protoc. 2001 Aug;8(1):25–31. doi: 10.1016/s1385-299x(01)00081-2.
参考文献:10.1021/bi00147a009
摘要:McTigue MA, Davies JF, Kaufman BT, Kraut J. Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin. Biochemistry. 1992 Aug 18;31(32):7264–73. doi: 10.1021/bi00147a009.
参考文献:10.1042/bj3040189
摘要:Werner ER, Schmid M, Werner-Felmayer G, Mayer B, Wachter H. Synthesis and characterization of 3H-labelled tetrahydrobiopterin. Biochem J. 1994 Nov 15;304 ( Pt 1)():189–93.
参考文献:10.1021/bi991448j
摘要:Moore J, Wood JM, Schallreuter KU. Evidence for specific complex formation between alpha-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infrared Fourier transform Raman spectroscopy. Biochemistry. 1999 Nov 16;38(46):15317–24. doi: 10.1021/bi991448j.
参考文献:10.1074/jbc.m509343200
摘要:Supangat S, Seo KH, Choi YK, Park YS, Son D, Han C, Lee KH. Structure of Chlorobium tepidum Sepiapterin Reductase Complex Reveals the Novel Substrate Binding Mode for Stereospecific Production of l-threo-Tetrahydrobiopterin. Journal of Biological Chemistry. 2006 Jan;281(4):2249–56. doi: 10.1074/jbc.m509343200.
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