CAS: 666-52-4; Acetone D6

上下游产品

CAS号67-64-1 丙酮 | CAS号22739-76-0 氘代异丙醇 | CAS号98-86-2 苯乙酮 | CAS号19214-96-1 异丙醇-D7 | CAS号124-38-9 二氧化碳 | CAS号3976-29-2 2-丙醇-1,1,1,3,3,3-d6 | CAS号778-60-9 [9,9-(2)H2]fluorene | CAS号1070-74-2 1,2-dideuterioethyne | CAS号24567-48-4 1,1,1,3,3,3,O-h... | CAS号53439-15-9 3-甲基-2-丁烯酸乙酯-d6 | CAS号3976-29-2 2-丙醇-1,1,1,3,3,3-d6 | CAS号3972-26-7 异丙醇-2-D1 | CAS号3979-51-9 2-丙醇-OD | CAS号20762-54-3 2-methylpropene-d8 | CAS号74-84-0 乙烷 | CAS号2031-95-0 1,1,1-trideuter... | CAS号1632-99-1 乙烷-d6 | CAS号19214-96-1 异丙醇-D7 | CAS号207456-83-5 4-甲基-3-戊烯-2-酮-D10

D8-Isopropyl Alcohol置于noyori'S Catalyst体系中,用 二氯甲烷-D2 作为反应溶剂,化学反应生成 氘代丙酮
参考文献:[p-(me2Ch)c6H4Me] Ru-(nhchphchphnso2C6H4-P-Ch3)催化的转移加氢中协同氢转移机理的动力学同位素效应证据.
标题:[p-(me2Ch)c6H4Me] Ru-(nhchphchphnso2C6H4-P-Ch3)催化的转移加氢中协同氢转移机理的动力学同位素效应证据.
摘要:[p-(me2Ch)c6H4Me] Ru(nhchphchphnso2C6H4-P-Ch3)(1)与异丙醇反应的同位素效应为1.79,氢从oh迁移至n,2.86,从ch转化为ru.氘从双标记物质转移的同位素效应(kchoh / Kcdod = 4.88)在两个同位素效应乘积的实验误差范围内.这些同位素效应为涉及氢同时从氧转移到氮以及从碳转移到钌的机制提供了令人信服的证据.
DOI:10.1021/jo0205457

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:WO-2024012791-A1
优先权日:2022-07-11
标题 :Electrochemical synthesis of pyrazolines and pyrazoles
发明人：BÄR ROBIN MAXIMILIAN; FORD MARK JAMES; KALDAS SHERIF JAMES; WALDVOGEL SIEGFRIED; HOFMANN SILJA; LINDEN MARTIN
权利人:BAYER AG
摘要:The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of formula (I). The process can be especially used for the synthesis of the herbicide safener mefenpyr-diethyl.

专利号:WO-2024201393-A1
优先权日:2023-03-29
标 题:Methods for the synthesis of nucleoside analogues and nucleosides analogues derived therefrom
发明人：BRITTON ROBERT; Muir Garrett; ANKETELL MATTHEW JAMES; HUXLEY COHAN; BAIKABI SUPING
权利人:UNIV FRASER SIMON
摘要:The present invention relates to methods for the synthesis of nucleoside analogues. More specifically, the present invention relates to methods for the synthesis of C4' substituted nucleoside analogues via the reaction of a soft nucleophile with a halohydrin ketone.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:WO-2013057110-A1
优先权日:2011-10-19
标 题:Method for the synthesis of citric acid esters
发明人：ALTENBACH HANS-JOSEF; LANGE KARSTEN; NANDI SUKHENDU; IHIZANE RACHID; JAKOB BERND; SCHNEIDER MANFRED
权利人:BERGISCHE UNI WUPPERTAL; ALTENBACH HANS-JOSEF; LANGE KARSTEN; NANDI SUKHENDU; IHIZANE RACHID; JAKOB BERND; SCHNEIDER MANFRED
摘要:The present invention discloses a targeted synthesis method for the synthesis of asymmetric monoesters and/or symmetrical diesters of citric acid through acidic esterification by using boric acid or a boronic acid as a catalyst. The boric/boronic acid simultaneously acts as a catalyst, as well as a 'protecting group' for the tertiary carboxylic acid, and therefore specifically only the asymmetric monoesters or symmetrical diesters are created.