CAS: 64967-39-1; (S)-2-(2-(2-(3-(Furan-2-yl)Acrylamido)-3-Phenylpropanamido)Acetamido)Acetic Acid
该化合物是一种合成三环衍生物,具有极利-谷地,能提高其在生化和药理研究中的效用.将2-氟基-谷地组纳入该组可以改善光物理特性,使之适合基于荧光的研究和蛋白活动分析.它的序列Phe-Gly-Gly,旨在模仿天然丙酸基质,便利对酶动能和抑制物的调查.复合物在生理条件下表现出稳定性,确保可靠的体外性能.其模块结构可以进一步功能化,使药物发现和机械学研究中能够有针对性地应用.这种聚苯酯对于研究蛋白酶和开发目标抑制剂特别有用.
- 英文名称(S)-2-(2-(2-(3-(Furan-2-yl)Acrylamido)-3-Phenylpropanamido)Acetamido)Acetic Acid
- 中文名称N-[3-(2-呋喃基)丙烯酰]-L-苯丙氨酰-甘氨酰-甘氨酸
- IUPAC名称(E)-(E)-(3-(furan-2-yl)acryloyl)-L-phenylalanylglycylglycine
- 其它别名2-{2-[(2S)-2-[(2E)-3-(Furan-2-yl)Prop-2-Enamido]-3-Phenylpropanamido]Acetamido}Acetic Acid; Angiotensin-Converting Enzyme Substrate; N-[3-(2-Furyl)Acryloyl]-Phe-Gly-Gly; N-(3-(2-Furyl)Acryloyl)-L-Pheny
- CAS编号64967-39-1
- MFCD编号:MFCD00036816
- 分子式:C20H21N3O6分子量:399.4
- 产品CID: 1632570
- 产品分类生物化工 → 氨基酸及其衍生物 → 甘氨酸类衍生物
- 相似结构搜索
- InChIKey: ZDLZKMDMBBMJLI-FDMDGMSGSA-N
- ZDLZKMDMBBMJLI-FDMDGMSGSA-N
- 计算化学: 氢键受体数6.0氢键供体数4.0可旋转键数10.0
物理性质
MSDS等安全信息
上下游产品
CAS号103972-53-8 Nα-furylacryloy... | CAS号2440-94-0 quinolin-8-yl e... | CAS号67998-15-6 furylacrylic ac... | CAS号4526-84-5 Nα-benzyloxycar... | CAS号539-47-9 2-呋喃丙烯酸合成工艺路线路线简述
📜呋喃丙烯酸酐 在 氢氧化钾,三乙胺体系中,用 甲醇,二氯甲烷作为反应溶剂,反应 5.5H,获得 N‑[3‑(2‑furyl)Acryloyl]-L-Phenylalanylglycylglycine
参考文献:Pozdnev,V. F.,Journal Of General Chemistry Of The Ussr,1986,Vol. 56,P. 613-617
标题:Pozdnev,V. F.,Journal Of General Chemistry Of The Ussr,1986,Vol. 56,P. 613-617
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Baudin B, Zendjabil M, Allouche S, Soudan B, Boutarfa N, Bénéteau-Burnat B, Potestat K, Caussé E, Chaabouni T, Ibrahim F, Taibi L. Measurement of angiotensin-I-converting enzyme in the blood: help for method validation. Ann Biol Clin (Paris). 2020 Aug 1;78(4):454-460. English. doi: 10.1684/abc.2020.1568. 5(5):e01747. doi: 10.1016/j.heliyon.2019.e01747.
3: Giromini C, Fekete ÁA, Givens DI, Baldi A, Lovegrove JA. Short-Communication: A Comparison of the In Vitro Angiotensin-1-Converting Enzyme Inhibitory Capacity of Dairy and Plant Protein Supplements. Nutrients. 2017 Dec 13;9(12):1352. doi: 10.3390/nu9121352.
4: Tanzadehpanah H, Asoodeh A, Saidijam M, Chamani J, Mahaki H. Improving efficiency of an angiotensin converting enzyme inhibitory peptide as multifunctional peptides. J Biomol Struct Dyn. 2018 Nov;36(14):3803-3818. doi: 10.1080/07391102.2017.1401001. Epub 2017 Dec 7. 24(2):332-342. doi: 10.1016/j.jfda.2015.11.010. Epub 2016 Feb 23.
合成参考文献
参考文献:10.1016/j.jbbm.2003.12.009|10.1016/s0165-022x(04)00024-7
摘要:Murray BA, Walsh DJ, FitzGerald RJ. Modification of the furanacryloyl-l-phenylalanylglycylglycine assay for determination of angiotensin-I-converting enzyme inhibitory activity. Journal of Biochemical and Biophysical Methods. 2004 May;59(2):127–37. doi: 10.1016/j.jbbm.2003.12.009.
参考文献:10.1007/bf03179884
摘要:Miano A, Quassinti L, Maccari E, Murri O, Amici D, Bramucci M. Purified angiotensin converting enzyme from Rana esculenta ovary influences ovarian steroidogenesis in vitro. Journal of Physiology and Biochemistry. 2003 Dec;59(4):269–76. doi: 10.1007/bf03179884.
参考文献:10.1093/clinchem/32.5.884
摘要:Beneteau B, Baudin B, Morgant G, Giboudeau J, Baumann FC. Automated kinetic assay of angiotensin-converting enzyme in serum. 1986 May 01;32(5):884–6. doi: 10.1093/clinchem/32.5.884.
参考文献:10.1152/ajpregu.1999.277.5.r1261
摘要:Miano A, Gobbetti A, Zerani M, Quassinti L, Maccari E, Murri O, Amici D, Bramucci M. Different modulation of aromatase activity in frog testis in vitro by ACE and ANG II. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1999 Nov 01;277(5):R1261–7. doi: 10.1152/ajpregu.1999.277.5.r1261.
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