CAS: 6343-98-2; 2-Hydrazinyl-5-Nitropyridine

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📜2-乙氧基-5-硝基吡啶置于乙醇,一水合肼体系中,化学反应生成 2-肼基-5-硝基吡啶
参考文献:Colonna; Dal Monte Casoni,Bollettino Scientifico Della Facolta Di Chimica Industriale Di Bologna,1944,Vol. 5,P. 32
标题:Colonna; Dal Monte Casoni,Bollettino Scientifico Della Facolta Di Chimica Industriale Di Bologna,1944,Vol. 5,P. 32

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CN-108484583-B
优先权日:2018-03-30
标题 :Synthesis and application of a colorimetric probe for the detection of Cu2+ and Ni2+ in water

专利号:CN-108484583-A
优先权日:2018-03-30
标 题 :Synthesis and application of a colorimetric method for detecting Cu2+ and Ni2+ probes in water