CAS: 59859-58-4; (3R,4S)-3-((4-Methoxyphenoxy)Methyl)-1-Methyl-4-Phenylpiperidine

上下游产品

Norfemoxetine 85441-57-2
(3R,4S)-1-(Tert-Butoxycarbonyl)-3-(P-Methoxyphenoxymethyl)-4-Phenylpiperidine 277744-02-2
Trans-1-Methyl-4-Phenyl-3-(Hydroxymethyl)Piperidine
(+/-)-Trans-4-Phenyl-3-Hydroxymethyl-1-Methylpiperidine
Trans-Tert-Butyl 3-(Hydroxymethyl)-4-Phenylpiperidine-1-Carboxylate
(3R,4S)-1-[(1R)-2-Hydroxy-1-Phenylethyl]-4-Phenyl-3-Piperidinemethanol 277743-94-9

📜(3R,4S)-1-(Tert-Butoxycarbonyl)-3-(P-Methoxyphenoxymethyl)-4-Phenylpiperidine置于lithium Aluminium Tetrahydride体系中,用 乙醚 作为反应溶剂,化学反应 2.0H,以74%的收率获得产物非莫西汀
参考文献:对映体反式3,4-二取代哌啶的合成.(+)-和(-)-帕罗西汀的对映体合成.
标题:对映体反式3,4-二取代哌啶的合成.(+)-和(-)-帕罗西汀的对映体合成.
摘要:(R)-苯基甘氨醇与5-氧戊酸甲酯反应反应生成双环内酰胺cis-1(动力学产物)或其异构体trans-1(在平衡条件下)为主要产物,将其转化为相应的(顺式或反式)不饱和内酰胺4和5.用烷基(或芳基)氰尿酸锂处理后,这些手性结构单元进行共轭加成,从而以高收率和立体选择性得到对映体反式3,4-取代的2-哌啶酮衍生物.(+)-非西西汀与已知抗抑郁药帕罗西汀的两种对映异构体的合成说明了这种转化的合成潜力.
DOI:10.1021/jo991816P

专利信息

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:US-2005282898-A1
优先权日:2004-06-01
标 题 :Methods for the synthesis of milnacipran and congeners thereof

专利号:US-2006084805-A1
优先权日:2004-09-30
标题:Synthesis of thienopyridinone compounds and related intermediates