CAS: 59-52-9; Dimercaprol

该化合物是一种主要用于处理重金属中毒,特别是砷,汞和铅的铬化剂,它是一种无色的淡黄色液体,有明显的大蒜味.二甲基丙酸酯的化学结构有两种硫醇(-SH)组,它能够形成稳定的金属离子复合物,便于其从体内排出.二甲基丙酸溶液在水和有机溶剂中溶解,能够用于多种用途.它通过肌肉内注射进行,并因其潜在的副作用而闻名,包括高血压,高血压和过敏反应.由于反应,必须小心处理,而且通常用于特定的临床情况.二甲基丙酸盐在切热疗法中的效力使它成为毒理学和紧急医学中的一个重要化合物,尽管其使用在支持其他侧作用较小的铬剂方面有所减少.

结构式图片

相似化合物

19721-22-3 96-27-5 3001-64-7

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号96-13-9 2,3-二溴-1-丙醇 | CAS号106-89-8 环氧氯丙烷 | CAS号616-23-9 2,3-二氯-1-丙醇 | CAS号507-09-5 硫代乙酸 | CAS号107-19-7 丙炔醇 | CAS号59051-15-9 2,3-bis(acetyls... | CAS号55487-28-0 2,3-bis-benzyls... | CAS号67-56-1 甲醇 | CAS号124-38-9 二氧化碳 | CAS号56-23-5 四氯化碳 | CAS号15205-69-3 2,3-bis(methyls... | CAS号103038-53-5 2,3-bis(sulfany... | CAS号538-74-9 二苄基硫醚 | CAS号55487-29-1 2,3-bis(benzyls... | CAS号103040-47-7 2,3-bis(sulfany... | CAS号7224-17-1 cadmium,2-(2,2-... | CAS号88942-49-8 4-(chloromethyl... | CAS号99848-17-6 2,3-bis(sulfany... | CAS号5694-47-3 (2,2-dimethyl-1... | CAS号58428-97-0 三丁酸2,3-二巯基-1-丙酯

合成工艺路线路线简述

  • 合成目标产物 2,3-Dimercapto-1-Propanol 主要起始原料 2,3-Dibromo-1-Propanol
  • (文献来源)合成步骤主要原料 2,3-Dibromo-1-Propanol
2,3-二氯-1-丙醇置于甲醇,Sodium Hydrogensulfide体系中,化学反应生成 2,3-二巯基-1-丙醇
参考文献:Ing,Journal Of The Chemical Society,1948,P. 1394
标题:Ing,Journal Of The Chemical Society,1948,P. 1394

海关参考信息

专利信息


专利号:US-9920160-B2
优先权日:2014-09-03
标题 :Method for synthesis of polymer containing multiple epoxy groups
发明人:GAO CHAO; ZHENG YAOCHEN; PENG LI; CAI SHENGYING; WENG ZHULIN
权利人:UNIV ZHEJIANG
摘要:A method for a synthesis of a polymer containing multiple epoxy groups includes steps of: under protection of nitrogen or argon, with a photosensitive free radical initiator under an ultraviolet light irradiation, initiating a mixture of a dithiol compound and alkynyl glycidyl ether or other alkynyl-containing compounds to proceed a thiol-yne polymerization, so as to obtain the polymer. The number of the epoxy groups is able to be adjusted through changing a type of a dithiol monomer, a mixing ratio of the dithiol monomer, and a mixing ratio between the alkynyl glycidyl ether and other alkynyl compounds. The present invention has advantages of: fast reaction, convenient process, easy post-processing, a large number of the epoxy groups, and adjustable and controllable content. The obtained polymer has a wide potential application in fields of coating, adhesive, ink, encapsulating material, resin for composite material, additive, high performance material, function material, and so on.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人:LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-6281372-B1
优先权日:1999-02-26
标 题 :Process for synthesis of vinyl esters from butene oligomers
发明人:WIESE KLAUS-DIETHER; OLBRICH PAUL; GABRIEL JUERGEN
权利人:OXENO OLEFINCHEMIE GMBH
摘要:A process for the synthesis of vinyl esters from butene oligomers, wherein butenes are oligomerized, the butene oligomers are separated from the oligomerized mixture, the butene oligomers are converted to carboxylic acids which are longer by one carbon atom, and the resulting carboxylic acids are converted to the corresponding vinyl esters. The butene oligomers are in particular dibutene, tributene and tetrabutene. The invention also relates to the use of the vinyl esters as plasticizers or as comonomers in polymerization reactions.

专利号:WO-2025017286-A1
优先权日:2023-07-14
标 题 :Novel synthesis of colloidal quantum dot ink and applications in semiconductor devices
发明人:VASHISHTHA PARTH; HE XIN; MEHTA JOSHUA; LIU JUNPENG; VO CONG-DUAN
权利人:QUANTUM SCIENCE LTD
摘要:The present invention provides a method for producing a nanocrystal composition comprising an inorganic ligand via a one-pot synthesis. The present invention also provides nanocrystals comprising novel inorganic ligands and the use of these nanocrystals. The present invention further provides the use of the novel inorganic ligands in the preparation of nanocrystals.

专利号:US-4426542-A
优先权日:1981-04-22
标题 :Synthesis of plasticizer and detergent alcohols
发明人:BARKER GEORGE E; FORSTER DENIS
权利人:MONSANTO CO
摘要:A preparation of a plasticizer alcohol, consisting of predominantly 2-propylheptanol, from linear butenes is described in which oxo product of the butenes is aldoled to condense n-pentaldehyde therein with very little cross-aldolization followed by hydrogenation to obtain the 2-propylheptanol with very small 2-propyl-4-methyl hexanol content. The alcohol product as phthalate ester has excellent plasticizer properties. Also processes are described for converting other olefins to alcohols by oxo, aldol and hydrogenation reactions, with particular attention to converting hexenes obtained by propylene dimerization to C14 alcohols suitable for preparation of detergents.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人:KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
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主要参考文献


1: Tian R, Shi R. Dimercaprol is an acrolein scavenger that mitigates acrolein- mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury. J Neurochem. 2017 Jun;141(5):708-720. doi: 10.1111/jnc.14025. Epub 2017 May 3.
2: Mückter H, Liebl B, Reichl FX, Hunder G, Walther U, Fichtl B. Are we ready to replace dimercaprol (BAL) as an arsenic antidote? Hum Exp Toxicol. 1997 Aug;16(8):460-5. doi: 10.1177/096032719701600807. 1(6700):199-200. 3(3):76. 41(3):378-83. doi: 10.1067/mem.2003.72. 2(5816):748-9. doi: 10.1136/bmj.2.5816.748.
7: MONTUSCHI E. Mercuric chloride poisoning treated with dimercaprol. Br Med J. 1953 Sep 5;2(4835):545. doi: 10.1136/bmj.2.4835.545.

合成参考文献


摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#04985
摘要:Quarterly Journal of Pharmacy & Pharmacology., 21(364), 1948
摘要:Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie., 223(408), 1954 []
摘要:Annales Pharmaceutiques Francaises., 5(172), 1947
摘要:Browning, E. Toxicity of Industrial Metals. 2nd ed. New York: Appleton-Century-Crofts, 1969., p. 315
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