CAS: 5581-75-9; 6-Phenylhexanoic Acid

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sodium diethylmalonate 1-Bromo-4-phenylbutane 5-benzylthiophene-2-carboxylic acid 6-phenylhexanenitrile 6-phenylhexanoyl chloride N-Phenacyl-glycin ethyl 4-(6-phenylhexylamino)benzoate 5-phenyl-n-valeric acid methyl ester

📜1-苯基-1-环己醇置于chromium(Vi) Oxide,溶剂黄146体系中,化学反应生成 苯已酸
参考文献:潜在的抗肿瘤药.27.ω-[4-(9-Ac啶基氨基)苯基]链烷酸的定量结构-抗白血病(l1210)活性关系.
标题:潜在的抗肿瘤药.27.ω-[4-(9-Ac啶基氨基)苯基]链烷酸的定量结构-抗白血病(l1210)活性关系.
摘要:9-苯胺基cr啶的简单羧酸衍生物(例如1,R =-Cooh)具有很高的实验抗白血病(l1210)活性.同源的1'-(ch2)ncooh同系物也被证明具有活性,并且l1210试验中寿命的最大增长与用作衡量亲脂性-亲水性平衡剂的rm值之间存在抛物线关系.相应的羧酰胺[1'-(ch2)nconh2]具有相似的抛物线关系,具有最佳的rm值,与酸的值相比有所偏离.较早检查的1'-Nhso2(ch2)nch3变体,它们的3-Nhcoch3同系物以及羧酰胺[1'-(ch2)nconh2]和磺酰胺[1'-(ch2)nso2Nh2]同源物可被视为一组得到的相关方程与仅羧酰胺变体的相关方程相同.该组的最佳rm值与酸的最佳rm值相等于辛醇-水规模的1.8 Log P单位.在该药物系列中,羧酸残基充当可接受的亲水性单元,在未电离的酸和完全电离的羧酸根阴离子之间提供log P贡献中间值.在含有羧酸或链烷磺酰胺侧链
DOI:10.1021/jm00203A005

专利信息

专利号:US-2021002677-A1
优先权日:2015-04-16
标 题:Synthesis of omega functionalized products
发明人：GONZALEZ RAMON; CHEONG SEOKJUNG; CLOMBURG JAMES M
权利人:GONZALEZ RAMON
摘要:The use of microorganisms to make omega- and/or omega-1-functionalized products through an iterative carbon chain elongation pathway that we call a reverse beta oxidation pathway. The pathway uses omega-functionalized CoA thioesters as primers and acetyl-CoA as the extender unit in a non-decarboxylative Claisen condensation, and then uses beta oxidation or fatty acid synthesis enzymes to complete the cycle, via reductase, dehydratase and reductase reactions. Various termination enzymes that act on the functionalized beta-keto acyl-CoA intermediates of the pathway and produce omega or omega-1 functionalized products. The action of termination enzymes on such intermediates yield a large variety of products.

专利号:US-2018135059-A1
优先权日:2015-04-16
标题 :Synthesis of omega functionalized products
发明人：GONZALEZ RAMON; CHEONG SEOKJUNG; CLOMBURG JAMES M
权利人:UNIV RICE WILLIAM M
摘要:The use of microorganisms to make omega- and/or omega-l-functionalized products through an iterative carbon chain elongation pathway that we call a reverse beta oxidation pathway. The pathway uses omega-functionalized CoA thioesters as primers and acetyl-CoA as the extender unit in a non-decarboxylative Claisen condensation, and then uses beta oxidation or fatty acid synthesis enzymes to complete the cycle, via reductase, dehydratase and reductase reactions. Various termination enzymes that act on the functionalized beta-keto acyl-CoA intermediates of the pathway and produce omega or omega-1 functionalized products. The action of termination enzymes on such intermediates yield a large variety of products.

专利号:WO-2016176339-A1
优先权日:2015-04-28
标 题 :Synthesis of omega-phenyl products and derivatives thereof
发明人：GONZALEZ RAMON; CHEONG SEOKJUNG; CLOMBURG JAMES M
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of microorganisms to make omega-phenyl products, including omega-phenyl carboxylic acids, alcohols, amines, methyl ketones and their beta-functionalized derivatives. This is achieved by utilizing an iterative carbon chain elongation pathway that uses omega-phenyl CoA thioester primers. The core enzymes in the pathway include thiolase, dehydrogenase, dehydratase and reductase. Native or engineered thiolases catalyze the condensation of omega-phenyl CoA thioester primers with acetyl-CoA as the extender unit to generate omega-phenyl β-keto acyl-CoA. Dehydrogenase converts omega-phenyl β-keto acyl-CoA to omega-phenyl β-hydroxy acyl-CoA. Dehydratase converts omega-phenyl β-hydroxy acyl-CoA to omega-phenyl enoyl-CoA. Reductase converts omega- phenyl enoyl-CoA to omega-phenyl acyl-CoA. The platform can be operated in an iterative manner (i.e. multiple turns) by using the resulting omega-phenyl acyl-CoA as primer and acetyl-CoA as extender unit in subsequent turns of the cycle. Termination pathways acting on any of the four omega-phenyl CoA thioester intermediates terminate the platform and generate various omega-phenyl carboxylic acids, alcohols, and amines with different degrees of β -reduction.

专利号:WO-2016168708-A1
优先权日:2015-04-16
标题:Synthesis of omega functionalized methylketones, 2-alcohols, 2-amines, and derivatives thereof
发明人：GONZALEZ RAMON; CHEONG SEOKJUNG; CLOMBURG JAMES M
权利人:UNIV RICE WILLIAM M
摘要:The use of microorganisms to make omega-functionalized methyl ketones, 2-alcohols, 2- amines, and their derivatives, including lactams, lactones, α,ω-l -diamines, co- 1 -amino- 1- alcohols, co-amino methyl ketones, co-hydroxy methyl ketones, co-amino-2-alcohols, α,ω-1- diols. This is achieved through an iterative carbon chain elongation pathway that uses omega- functionalized CoA thioesters as primers and acetyl-CoA as the extender unit, in combination with various termination enzymes that act on the omega-functionalized beta-keto acyl-CoA intermediates of the pathway. The action of these termination enzymes on such intermediates yield the aforementioned products.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-2024148312-A1
优先权日:2023-01-06
标题 :Compositions, systems, and methods for amino acid synthesis
发明人：YANG YANG; CHENG LEI; BO ZHIYU
权利人:UNIV CALIFORNIA
摘要:A method of forming a non-canonical amino acid includes contacting a substrate, a photocatalyst, and an amino acid with a pyridoxal enzyme in a solution and providing light sufficient to form the non-canonical amino acid from the solution. Compositions, systems, and methods for amino acid synthesis are included. Further, engineered enzymes to catalyze diverse C-C and C-heteroatom bond forming reactions are included.