CAS: 54916-66-4; 5-Bromo-2-Methoxynicotinic Acid

相似化合物

122433-41-4 213193-29-4 351410-47-4

上下游产品

2-methoxynicotinic acid methyl 5-bromo-2-methoxy-3-pyridinecarboxylate 5-Bromo-2-methoxy-nicotinic acid ethyl ester 5-bromo-N-ethyl-2-methoxynicotinamide 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide

📜2-甲氧基烟酸置于n-溴代丁二酰亚胺(Nbs)体系中,用 水 作为反应溶剂,化学反应 16.0H,以87%的收率获得产物5-溴-2-甲氧基烟酸
参考文献:2-甲氧基-3-氨基-5-吡啶硼酸频哪醇酯及其 中间体的合成方法
标题:2-甲氧基-3-氨基-5-吡啶硼酸频哪醇酯及其 中间体的合成方法
摘要:本发明涉及2‑甲氧基‑3‑氨基‑5‑吡啶硼酸频哪醇酯及其中间体的合成方法,具体地,所述合成方法以2‑甲氧基烟酸为起始原料,经过卤化,降解,脱保护和偶联的步骤制得了2‑甲氧基‑3‑氨基‑5‑吡啶硼酸频哪醇酯.本发明的方法合成路线短,方法简便且经济成本低,非常适合工业化生产.

专利信息

专利号:US-9364482-B2
优先权日:2013-06-24
标 题 :Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; NARGUND RAVI; XIAO DONG; ZORN NICOLAS; DANG QUN; MCCOMAS CASEY C; PENG XUANJIA; LI PENG; SOLL RICHARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)

专利号:US-9265773-B2
优先权日:2011-09-08
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9549917-B2
优先权日:2011-09-08
标 题 :Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:RU-1838313-C
优先权日:1987-09-04
标 题:Method of synthesis of spirocompound azolone or its n-oxide derivative or its basic salt with pharmacologically usable cation