CAS: 53606-06-7; 1-(Bromomethyl)-4-(Methylsulfonyl)Benzene

该化合物是一种多用途有机化合物,其特点是溴甲基(-CH2Br)和甲烷硫基(-SO2CH3),其功能组群附属于苯环.这一结构使其成为合成有机化学中有价值的中间体,特别是用于核生殖替代反应和交叉组合方法.溴甲基组是进一步功能化的电益场所,而全氟辛烷磺酸会增强回源性和稳定性.其应用包括制药合成,农用化学开发和材料科学.该组群的明确界定的再活动特征和与各种反应条件的兼容性有助于其构建复杂的分子结构. 正确处理因其潜在的乳液和刺激性能而值得注意.

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p-methylsulfonylbenzyl alcohol 4-(methylthio)benzyl alcohol 4-methylsulfonylbenzoic acid methylsulfonyl-4 benzoate d'ethyle (4-iodomethyl-phenyl)-methyl sulfone 4-(4-methanesulfonyl-benzyl)-morpholine (4-Methylsulfonyl-benzyl)-isothiuronium α,α-Dichlor-N-methyl-p-(4-methylsulfonyl-benzyloxy)-acetanilid

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    专利信息


    专利号:EP-1326851-B1
    优先权日:2000-10-13
    标 题 :Substituted dipeptides as growth hormone secretagogues
    发明人:DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
    权利人:LILLY CO ELI
    摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

    专利号:US-9856218-B2
    优先权日:2013-03-15
    标题:Inhibitors of PRMT5 and methods of their use
    发明人:BAIOCCHI ROBERT A; LI CHENGLONG; LAI HONGSHAN; SIF SAID
    权利人:OHIO STATE INNOVATION FOUNDATION
    摘要:In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:US-7396846-B2
    优先权日:2002-04-09
    标题:Growth hormone secretagogues
    发明人:EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
    权利人:LILLY CO ELI
    摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

    专利号:US-7125840-B2
    优先权日:2001-10-09
    标题:Substituted dipeptides as growth hormone secretagogues
    发明人:DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
    权利人:LILLY CO ELI
    摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

    专利号:US-7825149-B2
    优先权日:2006-01-19
    标 题 :Substituted imidazoles
    发明人:CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
    权利人:PFIZER LTD
    摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

    专利号:CN-119431200-A
    优先权日:2024-11-05
    标题:Synthesis method of etoricoxib intermediate

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    合成参考文献


    摘要:Evano, G., Science of Synthesis, (2007) 20, 147.
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