CAS: 53-46-3; Methantheline Bromide (200 Mg)

上下游产品

CAS号74-83-9 溴甲烷 | CAS号24539-72-8 9H-Xanthene-9-c... | CAS号82-07-5 呫吨-9-羧酸

📜呫吨-9-甲酸置于四氯化碳,硫酸,丙酮体系中,化学反应生成 溴甲胺太林
参考文献:Yoshida; Iwashige,Pharmaceutical Bulletin,1955,Vol. 3,P. 417,420
标题:Yoshida; Iwashige,Pharmaceutical Bulletin,1955,Vol. 3,P. 417,420

专利信息

专利号:US-3767657-A
优先权日:1971-03-31
标 题 :Process for the preparation of quinoxaline di n oxides
发明人：ROBERTSON R; KASUBICK R
权利人:PFIZER
摘要:IMPROVED SYNTHESIS OF ESTERS OF 2-QUINOXALINECARBOXYLIC ACID-1,4-DIOXIDES THROUGH A CONDENSATION OF A BENZOFUROXAN AND B-KETOESTER IN THE PRESENCE OF A CATALYTIC AMOUNT OF CALCIUM HYDROXIDE, AT A TEMPERATURE OF 40-80*C.

专利号:US-3759898-A
优先权日:1971-09-14
标 题 :Synthesis of alpha-(carbo(5-indanyloxy)) benzylpenicillin
发明人：NAKANISHI S
权利人:PFIZER
摘要:THE PREPARATION OF A-(CARBO(5-INDANYLOXY))BENZYLPENICILLIN VIA THE ESTERIFICATION OF A-CARBOXYPENICILLIN WITH 5-INDANOL IN THE PRESENCE OF N, N''-DICYCLOHEXYLCARBODIIMIDE IN A REACTION-INERT SOLVENT AT A PH OF 2-8.

专利号:US-3763162-A
优先权日:1971-08-06
标 题 :Transesterification of quinoxaline-2-carboxylic acid esters
发明人：KASUBICK R
权利人:PFIZER
摘要:SYNTHESIS OF 2-HYDROXYETHYL ESTERS OF 2-QUINOXALINECARBOXYLIC ACID-1,4-DIOXIDES THROUGH THE TRANSESTERIFICATION OF THE LOWER ALKYL ESTERS WITH ETHYLENE GLYCOL IN THE PRESENCE OF OXYGEN AND A CATALYTIC AMOUNT OF CALCIUM HYDROXIDE OF BARIUM HYDROXIDE AT A TEMPERATURE OF 30-50*C.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-4452796-A
优先权日:1982-06-14
标题:6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
发明人：BARTH WAYNE E
权利人:PFIZER
摘要:Beta-lactamase inhibitors which are 6-alpha- and 6-beta-(aminomethyl) and (1-aminoethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanediol esters thereof; or mixed methanediol esters with said beta-lactamase inhibitors and sulbactam. Pharmaceutical compositions comprising said beta-lactamase inhibitors and a conventional beta-lactam antibiotic, used in the treatment of bacterial infections. Compounds useful as intermediates in the synthesis of said beta-lactamase inhibitors. Antibacterial mixed bis-methanediol esters of said aminoalkyl penicillanic acid 1,1-dioxides and ampicillin or amoxicillin, also used in the treatment of bacterial infections; and intermediates therefor.

专利号:CA-2631582-C
优先权日:2006-01-13
标 题:Enzymatic large-scale synthesis of mucin glycoconjugates, and immunogenic applications thereof