CAS: 52571-45-6; N-(1-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-yl)-2-Oxo-1,2-Dihydropyrimidin-4-yl)Benzamide

相似化合物

13089-48-0 4836-13-9 1555759-60-8

上下游产品

diazomethane 4-benzoylcytidineN4-benzoylcytidine benzoic acid anhydride 2'-O-methylcytidine4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidineN4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine

1,3,5-三苯甲酰基-D-呋喃核糖置于硫酸氢铵,三氟化硼乙醚,Sodium Methylate,四氯化锡,六甲基二硅氮烷体系中,用 四氢呋喃,甲醇,二氯甲烷 作为反应溶剂,化学反应 3.2H,反应生成 N4-苯甲酰-2'-甲氧基胞苷
参考文献:Synthesis Of 2',3'-Differentiated Ribonucleosides Via Glycosylation Reactions With 2-O-Me Or 2-O-Tbdms Ribofuranose Derivatives. 1. Pyrimidine Series
标题:Synthesis Of 2',3'-Differentiated Ribonucleosides Via Glycosylation Reactions With 2-O-Me Or 2-O-Tbdms Ribofuranose Derivatives. 1. Pyrimidine Series
摘要:
DOI:10.1021/jo00341A005

专利信息

专利号:US-5013830-A
优先权日:1986-09-08
标题 :Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
发明人：OHTSUKA EIKO; INOUE HIDEO; MORISAWA HIROKAZU; SHIBAHARA SUSUMU; MUKAI SACHIKO; NISHIHARA TOHRU
权利人:AJINOMOTO KK
摘要:There is disclosed a compound having a double chain which is composed of an RNA (+chain) and a complementary DNA (-chain), wherein a portion of the DNA (-chain) has been replaced by an RNA or a derivative thereof, and wherein, when the compound is subjected to the action of an enzyme having a ribonuclease H activity, it is possible to preferentially cleave the RNA (+chain) in a position corresponding to the unsubstituted portion of the DNA (-chain). The compound can thus be used for the preferential cleavage of a phosphodiester bond in a specific position of RNA. Accordingly, the invention provides a useful means for preparing, for instance, a deletion mutant. There is also disclosed a mixed oligomer which comprises an oligomer of RNA or a derivative thereof and a DNA oligomer, wherein the RNA oligomer or a derivative thereof is conjugated to the DNA oligomer via a phosphate diester linkage between the 5'-hydroxyl group and the 3'-hydroxyl group in the ribose or deoxyribose moiety. There is further disclosed a nucleoside derivative of a given general formula for use as a starting material.

专利号:US-2025312367-A1
优先权日:2022-05-13
标 题:Oligonucleotides having a synthetic backbone and synthesis thereof
发明人：LI ZHEN; CHIRUTA CHANDRAMOULI; CHENG BO; NUMA MEHDI MICHEL DJAMEL; AZIMIOARA MIHAI; OLSSON CHASE ROBERT; ZHU RUI; FONG KIN
权利人:ADARX PHARMACEUTICALS INC
摘要:Provided herein are oligonucleotide-containing compounds, methods of delivering the compounds, and methods of treating diseases, disorders, and symptoms (e.g., central nervous system diseases, disorders, and symptoms) in a subject using the compounds.

专利号:EP-0260032-A2
优先权日:1986-09-08
标 题:Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers

专利号:EP-0260032-B1
优先权日:1986-09-08
标 题 :Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers