CAS: 516-85-8; Dehydroergosterol
该化合物是一种与ERgosterol 结构相关的激素衍生物,通常用作生物化学和生物物理研究的荧光探测器,其主要优势在于它能够在膜膜研究中模仿胆固醇和雌激素行为,从而由于其内在的荧光特性,能够实时地直观脂肪动力学.这一化合物对于调查雌激素-蛋白素相互作用,膜流体和脂质浮筏形成特别有用.它与各种光谱技术的相容性和兼容性使得它成为研究细胞系统中的雌激素贩运和分布的可靠工具.Dehytergosterol是分子分析和脂质研究中的关键参考标准.
相似化合物
474-69-1 434-16-2 57-87-4物理性质
上下游产品
麦角固醇 Ergosterol 57-87-4合成工艺路线路线简述
📜麦角固醇置于mercury(II) Diacetate,溶剂黄146体系中,用 乙醇,氯仿 作为反应溶剂,化学反应 40.0H,以55%的收率获得产物去氢麦角甾醇
参考文献:9,11-Secosteroids Pinnigorgiols B 和 E 的简明合成
标题:9,11-Secosteroids Pinnigorgiols B 和 E 的简明合成
摘要:Pinnigorgiols B 和 E 是 9,11-Secosteroids,具有独特的三环 γ-二酮框架.在此,我们报告了从廉价的市售麦角甾醇首次合成这些天然产物.该合成具有半频哪醇重排和酰基自由基环化/半缩酮化级联反应;后者有效地组装了三环γ-二酮骨架,一步形成了两个环和三个连续的立体中心.
DOI:10.1021/jacs.0C13426
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12263177-B2
优先权日:2019-02-07
标题:Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
发明人：MARTINEZ-MONTEMAYOR MICHELLE M; RIVAS FATIMA
权利人:UNIV CENTRAL DEL CARIBE; ST JUDE CHILDRENS RES HOSPITAL INC
摘要:The bioactive compounds of Ganoderma lucidum extract (GLE) responsible for anticancer activity were elucidated using NMR, X-ray crystallography and analogue derivatization, as well as anti-cancer activity studies. Structures of the seven most abundant GLE compounds are disclosed. Their selective efficacy against triple negative (TNBC) and inflammatory breast cancers (IBC) and other human cancer cell types (solid and blood malignancies) was shown, confirming potential their as anticancer agents.
专利号:US-9650407-B2
优先权日:2011-11-02
标 题 :Reprogramming of cellular adhesion
发明人：GARTNER ZEV JORDAN; SELDEN NICHOLAS SCOTT; TODHUNTER MICHAEL E; LIANG SAMANTHA ISABEL; WEBER ROBERT JOSEPH; JEE NOEL YOUNGHO; LIU JENNIFER S
权利人:UNIV CALIFORNIA
摘要:Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications.
专利号:WO-2024223953-A1
优先权日:2023-04-28
标 题:Calixarene compounds, their synthesis and use in pharmaceutical compositions
发明人：VANDER STRAETEN AURÉLIEN; BEVERNAEGIE ROBIN; JABIN IVAN; LAVENDOMME ROY
权利人:QUANTOOM BIOSCIENCES S A; UNIV BRUXELLES
摘要:The invention relates to new compounds of general Formula (I), which can be used in delivery systems for nucleotides. The present invention further relates to pharmaceutical compositions and their use thereof.
专利号:US-2025241930-A1
优先权日:2019-02-07
标 题 :Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
专利号:US-2022125805-A1
优先权日:2019-02-07
标 题:Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
专利号:US-2023047961-A1
优先权日:2019-12-03
标 题 :The cholesterol-syntesis intermediates for treatment demyelinating disorders
发明人：BERGHOFF STEFAN; SAHER GESINE
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a cholesterol-synthesis intermediate as pharmaceutically active agent and/or pharmaceutical composition comprising the cholesterol-synthesis intermediate optionally together with one or two further pharmaceutically active agent(s) for use in the prophylaxis and/or treatment of demyelinating disorders/diseases, in particular multiple sclerosis.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Mcintosh A L, Et Al. Fluorescence Techniques Using Dehydroergosterol To Study Cholesterol Trafficking[参考文献]: Lipids, 2008, 43: 1185-1208.[参考文献]: Avery L Mcintosh, Et Al. Fluorescence Techniques Using Dehydroergosterol To Study Cholesterol Trafficking. Lipids. 2008 Dec;43(12):1185-208.
[参考文献]: Daniel Wüstner, Et Al. Chromatic Aberration Correction And Deconvolution For Uv Sensitive Imaging Of Fluorescent Sterols In Cytoplasmic Lipid Droplets. Cytometry A. 2008 Aug;73(8):727-44.
[参考文献]: Daniel Wüstner, Et Al. Free-Cholesterol Loading Does Not Trigger Phase Separation Of The Fluorescent Sterol Dehydroergosterol In The Plasma Membrane Of Macrophages. Chem Phys Lipids. 2008 Aug;154(2):129-36.
[参考文献]: Daniel Wüstner, Et Al. Quantitative Assessment Of Sterol Traffic In Living Cells By Dual Labeling With Dehydroergosterol And Bodipy-Cholesterol. Chem Phys Lipids. 2011 Mar;164(3):221-35.
合成参考文献
参考文献:10.1248/bpb.19.573
摘要:YASUKAWA K, AKIHISA T, KANNO H, KAMINAGA T, IZUMIDA M, SAKOH T, TAMURA T, TAKIDO M. Inhibitory Effects of Sterols Isolated from Chlorella vulgaris on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation and Tumor Promotion in Mouse Skin. Biological & Pharmaceutical Bulletin. 1996;19(4):573–6. doi: 10.1248/bpb.19.573.
参考文献:10.1385/nmm:8:3:319
摘要:Burns MP, Igbavboa U, Wang L, Wood WG, Duff K. Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice. Neuromolecular Med. 2006;8(3):319–28. doi: 10.1385/nmm:8:3:319.
参考文献:10.1007/978-1-59745-178-9_25
摘要:Poteryaev D, Spang A. Application of RNAi technology and fluorescent protein markers to study membrane traffic in Caenorhabditis elegans. Methods Mol Biol. 2008;440():331–47. doi: 10.1007/978-1-59745-178-9_25.
参考文献:10.1007/bf02505758
摘要:Bastiaanse EML, Jongsma HJ, van der Laarse A, Takens-Kwak BR. Heptanol-induced decrease in cardiac gap junctional conductance is mediated by a decrease in the fluidity of membranous cholesterol-rich domains. The Journal of Membrane Biology. 1993 Nov 01;136(2):135–45. doi: 10.1007/bf02505758.
参考文献:10.1007/s11745-008-3194-1
摘要:McIntosh AL, Atshaves BP, Huang H, Gallegos AM, Kier AB, Schroeder F. Fluorescence Techniques Using Dehydroergosterol to Study Cholesterol Trafficking. Lipids. 2008 Jun 07;43(12):1185–208. doi: 10.1007/s11745-008-3194-1.
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