CAS: 41731-52-6; Ethyl 2-Chlorothiazole-4-Carboxylate

上下游产品

2-氨基噻唑-4-甲酸乙酯 2-Aminothiazole-4-Carboxylate 5398-36-7

📜3-乙氧基丙烯酸乙酯置于n-溴代丁二酰亚胺(Nbs),亚硝酸特丁酯,Copper Dichloride体系中,用 四氢呋喃,1,4-二氧六环,水,乙腈 作为反应溶剂,化学反应 2.17H,反应生成 2-氯噻唑-4-甲酸乙酯
参考文献:Heterocyclic Aminoberbamine Derivatives,The Preparation Process And Use Thereof
标题:Heterocyclic Aminoberbamine Derivatives,The Preparation Process And Use Thereof
摘要:本发明涉及一种具有化学式i的新型贝巴明衍生物或其药用盐,以及制备该衍生物的方法,包括所述化合物的药物组合物及其在制造抗肿瘤药物中的应用.

专利信息

专利号:US-9550757-B2
优先权日:2010-03-05
标题:Nuclear transport modulators and uses thereof
发明人：SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

专利号:US-10988466-B2
优先权日:2017-03-23
标题:Heterocyclic derivatives useful as SHP2 inhibitors
发明人：MA CUNBO; GAO PANLIANG; HU SHAOJING; XU ZILONG; HAN HUIFENG; WU XINPING; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.