CAS: 305-84-0; (S)-2-(3-Aminopropanamido)-3-(1H-Imidazol-5-yl)Propanoic Acid

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CAS号34653-21-9 1,3-thiazinane-... | CAS号71-00-1 L-组氨酸 | CAS号357409-05-3 (S)-2-(cyanoace... | CAS号378784-00-0 rhodium | CAS号7440-44-0 活性炭 | CAS号7389-97-1 (2S)-2-[3-(1,3-... | CAS号107-95-9 β-丙氨酸 | CAS号71-00-1 L-组氨酸 | CAS号107-95-9 β-丙氨酸

Nα-(Cyanoacetyl)-L-Histidine置于铑 氮,氢气,乙醇体系中,用 Ammonia Methanol 作为反应溶剂,25.0~90.0 °C,266.64 Kpa 条件下,反应 19.0H,以7.96 G (78%) Of A Slightly Greenish Solid With A Content (HPLC) Of 98% (M/m) Were Obtained的收率获得产物l-肌肽
参考文献:Method For Producing Beta-Alaninamides
标题:Method For Producing Beta-Alaninamides
摘要:本发明涉及一般式(i)的&bgr;-丙氨酰胺,其中:R1代表氢或c1-C6烷基,该烷基可选地被羟基,氨基,羧基,氨基甲酰基,甲硫基,胍基或可选取代的芳基或杂环芳基取代;r2代表氢或r1和r2共同形成式为-(ch2)n的基团,其中n代表3或4;r3代表氢,由等量的无机或有机阳离子补偿的负电荷,或代表c1-C6烷基.该&bgr;-丙氨酰胺是通过将相应的&agr;-氨基酸或相应的&agr;-氨基酸酯与氰乙酸反应形成氰乙酸酰胺,然后进行催化氢化而制备而成的,不需要使用氨基保护基.该方法特别适用于制备肌肉肽(&bgr;丙氨酰-L-组氨酸,R1=咪唑-4-基甲基,R2═r3═h),一种天然二肽,用作具有抗氧化作用的食品添加剂.

专利信息

专利号:US-8722852-B2
优先权日:2006-04-28
标 题 :Cosmetic composition for stimulating the synthesis of proteins of the basement membrane
发明人：ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC
权利人:ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC; DSM IP ASSETS BV
摘要:Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R 1 is H, C 1 -C 20 -alkyl, cycloalkyl or aryl-C 1 -C 4 -alkyl, n is 1-4, X is —O—, —NH— or —NR 2 — and R 2 H or C 1 -C 20 -alkyl; and at least one compound corresponding to the above formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR 2 — and both R 1 and R 2 are different from H, and the compounds corresponding to formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

专利号:US-2012094919-A1
优先权日:2009-03-16
标题 :Use of tripeptides
发明人：GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.

专利号:EP-1382327-A1
优先权日:2002-07-17
标 题 :Method of protection of the skin against ageing
发明人：DANOUX LOUIS; FREIS OLGA; PAULY GILLES
权利人:COGNIS FRANCE SA
摘要:A method for the production of means for the stimulation of human is proposednSkin cells as well as to protect against skin aging and damaging influencesnEnvironmental toxins and UV radiation, characterized in that the means at least onenSubstance containing the synthesis of energy donors of the mitochondrial respiratory chainnincreases while at the same time the rate of reactive oxygen species (ROS) innCell metabolism lowers.n n n Furthermore, the use of cosmetic and / or pharmaceutical preparations,ncontaining at least one substance which the synthesis of energy donorsnthe mitochondrial respiratory chain increases while at the same time the rate of reactive oxygen speciesn(ROS) in cell metabolism, to stimulate human skin cellsnas well as to the protection against skin aging and damaging influences by environmental poisons andnUV radiation proposed.

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

专利号:US-8895747-B2
优先权日:2009-07-27
标 题 :Method and substances for preparation of N-substituted pyridinium compounds
发明人：HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.