CAS: 30414-53-0; Methyl 3-Oxovalerate

相似化合物

42558-50-9 60793-22-8 1830-54-2

上下游产品

CAS号79-03-8 丙酰氯 | CAS号10191-25-0 3-氧代戊酸 | CAS号24342-04-9 2-戊炔酸甲酯 | CAS号37517-81-0 甲基丙二酰氯 | CAS号925-90-6 乙基溴化镁 | CAS号67-56-1 甲醇 | CAS号64074-05-1 2,2-dimethyl-5-... | CAS号616-38-6 碳酸二甲酯 | CAS号78-93-3 甲乙酮 | CAS号883528-73-2 2-Pentenoic aci... | CAS号105983-77-5 4-溴-3-氧代戊酸甲酯 | CAS号3952-66-7 2-氧代丁酸甲酯 | CAS号141602-25-7 4-氯-6-乙基嘧啶 | CAS号42558-50-9 (S)-羟基戊酸甲酯 | CAS号50405-45-3 5,6-二甲基-4-羟基-2-羰基吡喃 | CAS号180287-02-9 2-氟-3-氧代戊酸甲酯 | CAS号227183-98-4 methyl 4-fluoro... | CAS号439809-77-5 methyl ester of... | CAS号439809-76-4 methyl ester of... | CAS号196202-01-4 2,2-二氟-3-氧代戊酸甲酯

3-氧代戊酸置于i2,氯体系中,用 甲醇,Sodium Hydroxide 用作溶剂,化学反应生成3-氧代戊酸甲酯
参考文献:Antihypertensive Dihydropyridine Derivatives
标题:Antihypertensive Dihydropyridine Derivatives
摘要:化合物的化学式1是用于治疗高血压,充血性心力衰竭,心绞痛和血管痉挛性疾病的钙通道拮抗剂:##str1## 其中n是1到4的整数;R.Sub.1和r.Sub.2是较低的烷基;R.Sub.3是较低的烷基或烷氧基烷基;A是碳原子数为2到8的烷基;X.Sub.1和x.Sub.2分别独立地为--No.Sub.2,--Cf.Sub.3,Ch.Sub.3 O--,--Cn,--H,较低的烷基或卤素;Y是--O--,--S--,--S(O)--或--S(O).Sub.2--;R为h,较低的烷基,环烷基,烷氧基烷基,环烷氧基烷基,烷氧基环烷基,酰基,或饱和或不饱和的5或6元杂环烷基,可选择地用较低的烷基或烷氧基取代,其中杂原子是一个氧原子.

专利信息

专利号:US-6025492-A
优先权日:1996-08-30
标 题 :Synthesis of a hydrazone β-keto ester by the reaction with a diazo ester
发明人：SHAH AJIT S; CLARK JERRY D; MA YINONG; PETERSON JAMES C; PATELIS LEFTERIS
权利人:MONSANTO CO
摘要:The present invention relates to the synthesis of a hydrazone β-keto ester by the reaction of an alkyl diazoester with a hydrazone aldehyde in the presence of a Lewis acid In a preferred embodiment, the hydrazone β-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. A process for the production of a hydrazone aldehyde, which comprises contacting a hydrazine and glyoxal, is also described.

专利号:EP-0923540-B1
优先权日:1996-08-30
标题 :Synthesis of a hydrazone beta-keto ester by the reaction with a diazo ester
发明人：SHAH AJIT S; CLARK JERRY D; MA YINONG; PETERSON JAMES C; PATELIS LEFTERIS
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention relates to the synthesis of a hydrazone β-keto ester by the reaction of an alkyl diazo ester with a hydrazone aldehyde in the presence of a Lewis acid. In a preferred embodiment, the hydrazone β-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. The present invention also relates to a continuous process for the production of a hydrazone aldehyde comprising contacting a hydrazine and glyoxal, wherein the hydrazine and the glyoxal are added simultaneously to a reactor at a controlled rate.

专利号:US-3950389-A
优先权日:1968-10-04
标 题 :Stereospecific total steroidal synthesis via substituted C/D-trans indanones
发明人：HAJOS ZOLTAN GEORGE
权利人:HOFFMANN LA ROCHE
摘要:Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic compounds of the formula ##SPC1## n Wherein m is an integer having a value of 1 or 2; R 4 is hydrogen or lower alkyl; Z is lower alkylenedioxymethylene CH(OR 2 ) and carbonyl; R 8 when taken alone is hydrogen; R 9 when taken alone is lower alkoxycarbonyl, aryloxy-carbonyl, lower cycloalkyloxycarbonyl, carbonyl-halide, hydrogen, carboxy, formyl and methylene-X, where X is a leaving group and when taken together are methylene; with the proviso that when Z is carbonyl R 8 when taken alone is hydrogen; R 9 when taken alone is carbonyl halide, hydrogen, carboxy, formyl and methylene-X where X is a leaving group and when taken together are methylene and R 2 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenyl-lower alkyl, tetrahydropyranyl, lower alkanoyl, benzoyl, nitrobenzoyl, carboxy-lower alkanoyl, carboxybenzoyl, trifluoroacetyl and camphorsulfonyl n And reacting them in the case where R 8 and R 9 taken together are methylene or R 8 is hydrogen and R 9 is methylene-X with β-keto esters and other analogs of the formula ##EQU1## wherein R.sub. 6 is selected from the group CONSISTING OF ##EQU2## and LOWER ALKYL; R 7 is lower alkyl; R 15 is selected from the group consisting of oxo, lower alkylene-dioxy or (hydrogen and lower alkoxy); B is selected from the group consisting of lower alkoxy-carbonyl-methylene, lower-aryloxy-carbonyl-methylene, cyanomethylene, lower alkyl sulfinyl-methylene, lower alkyl sulfonyl-methylene, and R 25 and R 26 are independently selected from the group consisting of hydrogen, hydroxyl and lower alkyl.

专利号:US-4077983-A
优先权日:1974-06-24
标 题:Stereospecific total steroidal synthesis via substituted C/D-trans indanones
发明人：HAJOS ZOLTAN GEORGE
权利人:HOFFMANN LA ROCHE
摘要:Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic compounds of the formula ##STR1## wherein m is an integer having a value of 1 or 2; R 4 is hydrogen or lower alkyl; Z is lower alkylenedioxy, CH(OR 2 ) and carbonyl; R 8 when taken alone is hydrogen; R 9 when taken alone is lower alkoxycarbonyl, aryloxy-carbonyl, lower cycloalkyloxycarbonyl, carbonyl-halide, hydrogen, carboxy, formyl and methylene-X, where X is a leaving group and when taken together are methylene; with the proviso that when Z is carbonyl R 8 when taken alone is hydrogen; R 9 when taken alone is carbonyl halide, hydrogen, carboxy, formyl and methylene-X where X is a leaving group and when taken together are methylene and R 2 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenyl-lower alkyl, tetrahydropyranyl, lower alkanoyl, benzoyl, nitrobenzoyl, carboxy-lower alkanoyl, carboxybenzoyl, trifluoroacetyl and camphorsulfonyl n And reacting then in the case where R 8 and R 9 taken together are methylene or R 8 is hydrogen and R 9 is methylene-X with β-keto esters and other analogs of the formula ##STR2## wherein R 6 is selected from the group consisting of ##STR3## lower alkyl; R 7 is lower alkyl; R 15 is selected from the group consisting of oxo, lower alkylenedioxy or (hydrogen and lower alkoxy); B is selected from the group consisting of lower alkoxy-carbonylmethylene, lower-aryloxy-carbonyl-methylene, cyanomethylene, lower alkyl sulfinyl-methylene, lower alkyl sulfonyl-methylene, and R 25 and R 26 are independently selected from the group consisting of hydrogen, hydroxyl and lower alkyl.

专利号:US-4053486-A
优先权日:1974-06-24
标 题:Stereospecific total steroidal synthesis via substituted c/d-trans indanones
发明人：HAJOS ZOLTAN GEORGE
权利人:HOFFMANN LA ROCHE
摘要:Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic compounds of the formula ##STR1## WHEREIN M IS AN INTEGER HAVING A VALUE OF 1 OR 2; R 4 is hydrogen or lower alkyl; Z is lower alkylenedioxy, CH(OR 2 ) and carbonyl; R 8 when taken alone is hydrogen; R 9 when taken alone is lower alkoxy-carbonyl, aryloxy-carbonyl, lower cycloalkyloxy-carbonyl, carbonyl-halide, hydrogen, carboxy, formyl and methylene-X, where X is a leaving group and when taken together are methylene; with the proviso that when Z is a carbonyl R 8 when taken alone is hydrogen; R 9 when taken alone is carbonyl-halide, hydrogen, carboxy, formyl and methylene-X where X is a leaving group and when taken together are methylene and R 2 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenyl-lower alkyl, tetrahydropyranyl, lower alkanoyl, benzoyl, nitrobenzoyl, carboxy-lower alkanoyl, carboxybenzoyl, trifluoroacetyl and camphorsulfonyl n And reacting them in the case where R 8 and R 9 taken together are methylene or R 8 is hydrogen and R 9 is methylene-X with β-keto esters and other analogs of the formula ##STR2## wherein R 6 is selected from the group consisting ##STR3## and lower alkyl; R 7 is lower alkyl; R 15 is selected from the group consisting of oxo, lower alkylenedioxy or (hydrogen and lower alkoxy); B is selected from the group consisting of lower alkoxy-carbonyl-methylene, lower-aryloxy-carbonyl-methylene, cyanomethylene, lower alkyl sulfinyl-methylene, lower alkyl sulfonyl-methylene, and R 25 and R 26 are independently selected from the group consisting of hydrogen, hydroxyl and lower alkyl.

专利号:US-3984473-A
优先权日:1968-10-04
标题 :Stereospecific total steroidal synthesis via substituted C/D-trans indanones
发明人：HAJOS ZOLTAN GEORGE
权利人:HOFFMANN LA ROCHE
摘要:Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic compounds of the formula ##SPC1## n Wherein m is an integer having a value of 1 or 2; R 4 is hydrogen or lower alkyl; Z is lower alkylenedioxy, CH(OR 2 ) and carbonyl; R 8 when taken alone is hydrogen; R 9 when taken alone is lower alkoxy-carbonyl, aryloxy-carbonyl, lower cycloalkyloxy-carbonyl, carbonyl-halide, hydrogen, carboxy, formyl and methylene-X, where X is a leaving group and when taken together are methylene; with the proviso that when Z is carbonyl R 8 when taken alone is hydrogen; R 9 when taken alone is carbonyl halide, hydrogen, carboxy, formyl and methylene-X where X is a leaving group and when taken together are methylene and R 2 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenyl-lower alkyl, tetrahydropyranyl, lower alkanoyl, benzoyl, nitrobenzoyl, carboxy-lower alkanoyl, carboxy-benzoyl, trifluoroacetyl and camphorsulfonyl and reacting them in the case where R 8 and R 9 taken together are methylene or R 8 is hydrogen and R 9 is methylene-X with β-keto esters and other analogs of the formula ##EQU1## wherein R 6 is selected from the group consisting of ##EQU2## and lower alkyl; R 7 is lower alkyl; R 15 is selected from the group consisting of oxo, lower alkylene-dioxy or (hydrogen and lower alkoxy); B is selected from the group consisting of lower alkoxy-carbonyl-methylene, lower-aryloxy-carbonyl-methylene, cyanomethylene, lower alkyl sulfinyl-methylene, lower alkyl sulfonyl-methylene, and R 25 and R 26 are independently selected from the group consisting of hydrogen, hydroxyl and lower alkyl.