CAS: 27975-19-5; (4R,4As,6Ar,9S,11Ar,11Bs)-4,9,11B-Trimethyl-8-Oxotetradecahydro-6A,9-Methanocyclohepta[a]Naphthalene-4-Carboxylic Acid

该化合物是一种来自石化甘油表面的二苯基化合物,主要通过对石化表面进行水解获得,它展示了一种四环 ent-kaurene结构,有助于其应用的稳定性和多功能性.作为非热浓缩糖衍生物,Isosteviol对制药和食品工业感兴趣,因为它具有潜在的生物活性,包括反炎,抗血压和抗氧化性.它的高热和pH稳定性使其适合在不同条件下进行配制.此外,Isosteviol是合成Steviol类物的关键中间体,为研究和开发提供了效用.它的低毒性特征进一步支持其在功能成分和治疗性探索中的使用.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号57817-89-7 甜菊苷 | CAS号1347574-22-4 13-methyl-16-ox... | CAS号29584-19-8 (5β,8α,9β,10α,1... | CAS号7664-93-9 硫酸 | CAS号50-99-7 D(+)-无水葡萄糖

合成工艺路线路线简述

    📜Stevioside置于硫酸体系中,化学反应 7.0H,以50.6%的收率获得异甜菊醇
    参考文献:异斯特维醇双亲性衍生物及其制备方法
    标题:异斯特维醇双亲性衍生物及其制备方法
    摘要:本发明公开了一类异斯特维醇双亲性衍生物的结构及其制备方法,属于超分子化学技术领域.所述化合物基于天然产物异斯特维醇,其19位与聚醚链相连,端头为不同的季铵盐,结构式如图1所示,其中r为吡啶季铵盐,咪唑季铵盐等.

    海关参考信息

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Zhang H, Zan J, Zhong K, Lu M, Sun X, Tan W. Neuroprotective Effects of Isosteviol Sodium through Increasing CYLD by the Downregulation miRNA-181b. Brain Res Bull. 2018 May 25. pii: S0361-9230(18)30108-4. doi: 10.1016/j.brainresbull.2018.05.015. [Epub ahead of print] doi: 10.1016/j.jpba.2018.05.022. Epub 2018 May 17. doi: 10.1530/JOE-17-0681. Epub 2018 May 2. doi: 10.1097/WNR.0000000000001033.
    6: Zhang H, Sun X, Xie Y, Tian F, Hu H, Tan W. Isosteviol Sodium Inhibits Astrogliosis after Cerebral Ischemia/Reperfusion Injury in Rats. Biol Pharm Bull. 2018;41(4):575-584. doi: 10.1248/bpb.b17-00921. doi: 10.18632/oncotarget.22969. eCollection 2018 Jan 5.
    8: Kachingwe BH, Uang YS, Huang TJ, Wang LH, Lin SJ. Development and validation of an LC-MS/MS method for quantification of NC-8 in rat plasma and its application to pharmacokinetic studies. J Food Drug Anal. 2018 Jan;26(1):401-408. doi: 10.1016/j.jfda.2017.09.003. Epub 2017 Nov 11. pii: E127. doi: 10.3390/nu10020127.

    合成参考文献


    摘要:Zhongguo Yaolixue Yu Dulixue Zazhi., 8(33), 1994
    参考文献:10.1021/np100915q
    摘要:Chou BH, Yang LM, Chang SF, Hsu FL, Wang LH, Lin WK, Liu PC, Lin SJ. Transformation of isosteviol lactam by fungi and the suppressive effects of its transformed products on LPS-induced iNOS expression in macrophages. J Nat Prod. 2011 Jun 24;74(6):1379–85. doi: 10.1021/np100915q.
    参考文献:10.1530/joe-17-0681
    摘要:Tang SG, Liu XY, Ye JM, Hu TT, Yang YY, Han T, Tan W. Isosteviol ameliorates diabetic cardiomyopathy in rats by inhibiting ERK and NF-κB signaling pathways. J Endocrinol. 2018 Jul;238(1):47–60. doi: 10.1530/joe-17-0681.
    参考文献:10.1021/acs.jnatprod.0c00134
    摘要:Andreeva OV, Garifullin BF, Sharipova RR, Strobykina IY, Sapunova AS, Voloshina AD, Belenok MG, Dobrynin AB, Khabibulina LR, Kataev VE. Glycosides and Glycoconjugates of the Diterpenoid Isosteviol with a 1,2,3-Triazolyl Moiety: Synthesis and Cytotoxicity Evaluation. J Nat Prod. 2020 Aug 28;83(8):2367–80. doi: 10.1021/acs.jnatprod.0c00134.
    参考文献:10.1111/jcmm.15721
    摘要:Mohammed Abdul KS, Rayadurgam J, Faiz N, Jovanović A, Tan W. Cardioprotection by isosteviol derivate JC105: A unique drug property to activate ERK1/2 only when cells are exposed to hypoxia‐reoxygenation. J Cellular Molecular Medi. 2020 Aug 14;24(18):10924–34. doi: 10.1111/jcmm.15721.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知