专利号:WO-0140193-A1 优先权日:1999-12-03 标题:Method for the synthesis of pyrazolines 发明人:BOLDI ARMEN M 权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M 摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.
专利号:US-2002103381-A1 优先权日:2000-11-30 标 题 :Method for the synthesis of pyrazolines 发明人:BOLDI ARMEN M 摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.
专利号:EP-0830136-B1 优先权日:1995-03-07 标 题:New cryptophycins from synthesis 发明人:MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; HEMSCHEIDT THOMAS K; GOLAKOTI TRIMURTULU 权利人:UNIV HAWAII; UNIV WAYNE STATE 摘要:Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat neoplasia.
专利号:US-6013626-A 优先权日:1993-12-21 标题 :Cryptophycins from synthesis 发明人:MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; GOLAKOTI TRIMURTULU; HEMSCHEIDT THOMAS K 权利人:UNIV HAWAII; UNIV WAYNE STATE 摘要:A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.
专利号:EP-0844261-A1 优先权日:1996-11-21 标题:Dispersions containing polyurethanes with carbonyl groups in ketone function 发明人:KOKEL NICOLAS DR; GULBINS ERICH DR; RAU MARIA GYOPAR DR; FISCHER GERHARD 权利人:BASF AG 摘要:R 1 , R 2 , R 3 jeweils Wasserstoff, C 1 - bis C 24 -Alkyl oder C 6 - bisnC 24 -Alkenyl R 4 Wasserstoff R 5 , R 6 a) gemeinsam C 4 - bis C 10 -Alkandiyl, b) jeweils C 2 - bis C 10 -Alkyl, C 5 - bis C 8 -Cycloalkylnoder C 7 - bis C 20 -Aralkyl, c) jeweils ein hydroxylterminiertes Poly-(C 2 - bisnC 4 -alkylenoxid), oder d) ein Rest R 5 oder R 6 die unter (a) bis (c) angegebenenBedeutung und der andere Rest Wasserstoffnoder ein Rest der Formel IIn nin der X C 2 - bis C 6 -Alkandiyl bedeutet und R 7 gleichbedeutend ist mit R 5 oder R 6 mit der Ausnahme,ndaß R 7 nicht ein Rest der Formel II bedeutet, nwobei n die Reste R 5 und R 6 in jedem der Fälle (a) bis (d) insgesamtneine (1) an ein aliphatisches C-Atom gebundene Hydroxylgruppenntragen, gegebenenfalls der Rest R 5 und/oder R 6 1 oder 2 aromatischngebundene Hydroxylgruppen oder 1 Nitril-, tertiäre Amino-,nCarbonsäure- oder Sulfonsäuregruppe, die gegebenenfalls innForm ihrer Salze vorliegen, trägt, und die mittlere Funktionalität (F) aller Aufbaukomponenten desnPolyurethans (A), bezogen auf die Funktionalitäten, die beimnAufbau des Polyurethans (A) in einer Additionsreaktion miteinandernreagieren, 1,5 bis 2,2 beträgt. Aqueous dispersions containing a polyurethane (A) with structural units which differ from compounds of the formula (I) in which the substituents have the following meaning: R 1 , R 2 , R 3 in each case hydrogen, C 1 - to C 24 -alkyl or C 6 - to C 24 -alkenyl R 4 hydrogen R 5 , R 6 a) together C 4 - to C 10 -alkanediyl, b) in each case C 2 to C 10 alkyl, C 5 to C 8 cycloalkyl or C 7 to C 20 aralkyl, c) in each case a hydroxyl-terminated poly (C 2 - to C 4 -alkylene oxide), or d) a radical R 5 or R 6 has the meaning given under (a) to (c) and the other radical is hydrogen or a radical of the formula II in the X C 2 - to C 6 -alkanediyl means and R 7 is equivalent to R 5 or R 6 with the exception that R 7 does not represent a radical of the formula II, in which the radicals R 5 and R 6 in each of cases (a) to (d) carry a total of one (1) hydroxyl groups bonded to an aliphatic carbon atom, optionally the radical R 5 and / or R 6 carries 1 or 2 aromatically bound hydroxyl groups or 1 nitrile, tertiary amino, carboxylic acid or sulfonic acid group, which are optionally present in the form of their salts, and the average functionality (F) of all structural components of the polyurethane (A), based on the functionalities which react with one another during the synthesis of the polyurethane (A) in an addition reaction, is 1.5 to 2.2.
专利号:US-2017266326-A1 优先权日:2011-09-09 标题:Compositions, methods, and systems for the synthesis and use of imaging agents
摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 192. 摘要:Kantlehner, W., Science of Synthesis, (2006) 24, 358. 摘要:Bingham, M. J.; Greaney, M. F., Science of Synthesis, (2008) 36, 1015.