CAS: 2381-85-3; Nile Blue Chloride

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33203-82-6 7385-67-3 1562-90-9

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2-Hydroxy-4-imino-4H-naphthalen-1-one 2-amino-5-(diethylamino)phenol dihydr°Chloride [1,4]naphthoquinone-bis-chlorimin 3-diethylaminophenol1,3-diisopropylurea

📜C37H38N3O7(1+)*cl(1-)置于3,6-二-2-吡啶基-1,2,4,5-四嗪体系中,用 Aq. Buffer 用作溶剂,化学反应生成氯化耐尔蓝
参考文献:四嗪响应自焚连接子
标题:四嗪响应自焚连接子
摘要:释放自杀:阿霉素通过自消灭性连接体与peg-B-Dox纳米颗粒结合,该连接体由乙烯基醚笼蔽的苯酚组成,在用四嗪激活da Inv后会被1,6消除,从而导致货物释放并开启细胞毒性作用.
Doi:10.1002/cbic.201600560

专利信息

专利号:US-12018313-B2
优先权日:2016-12-28
标题:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles
发明人：EMBREE MALLORY
权利人:NATIVE MICROBIALS INC
摘要:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles, including dosed microbial ensembles and inoculative microbial ensembles, are disclosed.

专利号:US-10150160-B2
优先权日:2014-12-04
标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
发明人：PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT
权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A
摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

专利号:WO-2012088402-A1
优先权日:2010-12-22
标题 :Synthesis of conolidine and discovery of a potent non-opioid analgesic for pain
发明人：BOHN LAURA M; MICALIZIO GLENN C
权利人:SCRIPPS RESEARCH INST; BOHN LAURA M; MICALIZIO GLENN C
摘要:The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example,(+/- )-,(+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain.

专利号:US-9625466-B2
优先权日:2011-04-06
标题 :Signal amplification methods for the imaging of protein synthesis and neurotransmitter transport
发明人：BLANCHARD SCOTT C; ALTMAN ROGER B
权利人:BLANCHARD SCOTT C; ALTMAN ROGER B; UNIV CORNELL
摘要:The present invention describes the synthesis of biological samples that can be used for the purpose of enhancing the signal-to-noise ratios achievable during the imaging of protein synthesis, amino acid transport and neurotransmitter transport, particularly in applications where single-molecule resolution is demanded. The present invention provides quencher-labeled elongation factor (EF-Tu) and fluorophore-labeled tRNA. When these molecules are present in a ternary complex with GTP, the fluorescently-labeled tRNA is quantitatively quenched. Once the tRNA is incorporated into an actively translating ribosome, however, a burst of fluorescence is released and can be detected by a variety of techniques, including smFRET imaging. The invention further provides novel EF-Tu constructs for achieving quencher labeling at high levels while retaining native or near native activity in the translation reactions, as well as methods for preparing stable ternary complexes, methods of protein sequencing, methods of detecting amino acid transport using a proteoliposome assay system and the proteoliposomes systems and methods of imaging translation events in single living cells. The present invention should have an immediate impact on next-generation sequencing technologies and the detection of neurotransmitter transporter activities in both in vitro and in vivo settings, a critical component of drug activity/screening assays targeting this important class of molecules.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-9845501-B2
优先权日:1998-12-14
标题 :System and methods for nucleic acid sequencing of single molecules by polymerase synthesis
发明人：WILLIAMS JOHN G K
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC; PACIFIC OF BIOSCIENCES OF CALIFORNIA INC
摘要:This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi moieties released from NTPs as a polymerase extension product is created.