CAS: 2304-81-6; N-((2S,3R,E)-1,3-Dihydroxyoctadec-4-En-2-yl)Stearamide

上下游产品

stearic acid N-hydroxysuccinimide ester (2S,3R,4E)-2-amino-4-°Ctadecene-1,3-diol N-tert-butyloxycarbonylsphingosine sphingomyelin°Ctadecanoic acid [(E)-(1S,2R)-2-hydroxy-1-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethyl)-heptadec-3-enyl]-amide N-stearoyl-1-O-trityl-D-erythro-sphingosine (2S,3R,4E)-3-O-benzoyl-2-°Ctadecanamido-4-°Ctadecene-1,3-diol 3-O-benzoyl-N-stearoyl-1-O-trityl-D-erythro-sphingosine

📜正十四烷基三苯基溴化膦置于吡啶,Sodium Tetrahydroborate,Sodium Azide,溶剂黄146,苯基锂,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,乙醚,二氯甲烷,环己烷,水,N,N-二甲基甲酰胺,异丙醇 用作溶剂,化学反应 56.33H,反应生成N-硬脂酰神经鞘氨醇
参考文献:从单-O-异亚丙基-D-木糖或-D-半乳糖制备d-赤型-鞘氨醇及其相关化合物的新途径
标题:从单-O-异亚丙基-D-木糖或-D-半乳糖制备d-赤型-鞘氨醇及其相关化合物的新途径
摘要:摘要描述了由d-木糖或d-半乳糖有效合成d-赤型-鞘氨醇和-神经酰胺的方法.2,4-O-异亚丙基-D-苏糖及其甲酸酯的混合物是一步合成的,该混合物可从3,5-O-异亚丙基-D-木呋喃糖或4,6-O-异亚丙基-D-吡喃半乳糖中得到.用三苯基膦基四-和-十六-癸基进行wittig链化.通过在c-2处引入叠氮基并将叠氮化物选择性还原,分别将所得的1,3-O-异丙基亚甲基化的c 18和c 20烯烃转化为相应的1,3-O-保护的鞘氨醇具有2(S),3(R)-D-赤型构型,通过与硬脂酰基或木质素酰基的n-酰化序列,并水解除去异亚丙基,从中制备了多种神经酰胺.
Doi:10.1016/0008-6215(86)84009-5

专利信息

专利号:US-9546161-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
发明人：HIRTH BRADFORD H; SIEGEL CRAIG
权利人:GENZYME CORP
摘要:Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

专利号:US-9586984-B2
优先权日:2007-04-09
标题:One-pot synthesis of alpha/beta-O-glycolipids
发明人：GERVAY-HAGUE JACQUELYN; DU WENJUN; KULKARNI SUVARN S; SCHOMBS MATTHEW
权利人:UNIV CALIFORNIA
摘要:The present invention provides a one-pot method of preparing an unprotected α-O-glycolipid. The first step involves contacting a protected α-iodo sugar with a catalyst and a lipid comprising a hydroxy group, under conditions sufficient to prepare a protected α-O-glycolipid. The second step involves deprotecting the protected α-O-glycolipid under conditions sufficient to prepare the unprotected α-O-glycolipid, wherein the contacting and deprotecting steps are performed in a single vessel. The present invention also provides a one-pot method of preparing an unprotected β-O-glycolipid following the steps for the preparation of the unprotected α-O-glycolipid.

专利号:US-7041831-B2
优先权日:2001-11-26
标题:Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
发明人：HIRTH BRADFORD H
权利人:GENZYME CORP
摘要:Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): n nThe method comprises the step of reacting an aldehyde compound R 10 CHO with an isonitrile compound represented by Structural Formula (II):

专利号:US-11529370-B2
优先权日:2017-11-24
标 题 :Use of composition comprising stem cell-derived exosome as effective ingredient in strengthening skin barrier and improving skin barrier function
发明人：YI YONG WEON; CHO BYONG SEUNG
权利人:EXOCOBIO INC
摘要:A composition for strengthening skin barrier or improving skin barrier function is able to improve objective indicators related to the protection of skin barrier, the strengthening of skin barrier, and/or the improvement of skin barrier function. The composition exhibits the effects of increasing the amount of ceramides, dihydroceramides and sphingoid bases, increasing the activities of enzymes that are involved in the synthesis thereof, and decreasing the activities of enzymes that are involved in the degradation thereof. In addition, the composition is able to restore skin barrier function by reducing TSLP, IL-4, and IL-13 which are closely associated with skin barrier damage, and thus interrupting a vicious circle in which the lipids and proteins contributing to skin barrier decrease.

专利号:US-2003050299-A1
优先权日:2001-07-16
标 题 :Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors

专利号:US-7196205-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors