📜Sodium Methylate,对溴溴苄置于乙酸乙酯,水,Brine,Sodium Sulfate-Iii体系中,用 甲醇 用作溶剂,化学反应 2.0H,以to Obtain The Title Product As A Colourless Oil (110.6 G; 96%)的收率获得4-溴基苄基甲醚 参考文献:Glyt1 Transporter Inhibitors And Uses Thereof In Treatment Of Neurological And Neuropsychiatric Disorders 标题:Glyt1 Transporter Inhibitors And Uses Thereof In Treatment Of Neurological And Neuropsychiatric Disorders 摘要:提供了式(I)的化合物或其盐,其中r1,R2,R3,R4,R5,R6,R7,R8,R15和m如描述中所定义.还揭示了将这些化合物用作药物治疗神经系统和神经精神障碍,特别是精神病,痴呆或注意力缺陷障碍的用途,以及用于制造这些药物的药物制剂.该发明还包括制造这些化合物和制药配方的过程.
专利号:US-8268936-B2 优先权日:2005-01-04 标题:Synthesis of hybrid block copolymers and uses thereof 发明人:BREITENKAMP KURT; SILL KEVIN N 权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC 摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.
专利号:US-2012196989-A1 优先权日:2005-02-11 标题:Synthesis of homopolymers and block copolymers 发明人:BREITENKAMP KURT; SILL KEVIN N 权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC 摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.
专利号:US-9512426-B2 优先权日:2009-12-17 标 题:Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications 发明人:BUTORA GABOR; DAVIES IAN W; FLANAGAN WILLIAM MICHAEL; FU WENLANG; KENSKI DENISE M; QI NING 权利人:SIRNA THERAPEUTICS INC 摘要:It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.
专利号:US-2011124840-A1 优先权日:2005-02-11 标 题:Synthesis of Homopolymers and Block Copolymers
专利号:US-2011021718-A1 优先权日:2005-01-04 标 题:Synthesis of hybrid block copolymers and uses thereof
专利号:US-6207836-B1 优先权日:1993-02-17 标 题 :Indolin-2-one derivatives 发明人:ESAKI TORU; EMURA TAKASHI; HOSHINO EIICHI 权利人:CHUGAI PHARMACEUTICAL CO LTD 摘要:A compound represented by formula (I):wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, -OR5, -SR5 or -NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent -CH2-, -NH- or -O-; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.