CAS: 13482-23-0; 4-Methoxycyclohexanone

相似化合物

13482-22-9 18068-06-9 22188-03-0

上下游产品

4-羟基环己酮 4-Hydroxycyclohexanone 13482-22-9
4-甲氧基环己醇 4-Methoxycyclohexan-1-Ol 18068-06-9

4-羟基环己酮乙二醇缩醛置于盐酸,Potassium Hydride体系中,用 四氢呋喃,水 用作溶剂,化学反应 49.02H,反应生成4-甲氧基环己酮
参考文献:4-取代环己酮衍生的腙,亚胺和相应盐中静电效应的光谱和 X 射线晶体学证据
标题:4-取代环己酮衍生的腙,亚胺和相应盐中静电效应的光谱和 X 射线晶体学证据
摘要:发现几种 4-取代的环己酮腙盐的轴向构象异构体在溶液中占主导地位.分子电荷和溶剂极性的变化导致每个分子的构象偏好发生变化,这与轴向构象异构体的静电稳定一致.1 H NMR 光谱分析用于通过与构象限制反式的比较来确定环己酮衍生底物的结构-Decalone 衍生物和计算模型.X 射线晶体学证明侧链苄氧基的轴向构型是固态亚胺离子的优选构象.还确定中性腙的结构有利于固态苄氧基侧基的轴向构型.
Doi:10.1021/jo200950S

专利信息

专利号:WO-2024209478-A1
优先权日:2023-04-07
标题:Synthesis of cyclic ketone from cyclic amino acid
发明人：BICIDI JAYAPAL REDDY; RAMIYA RAJARAM AMARESH; PILLAI BIJUKUMAR GOPINATHAN
权利人:ADAMA MAKHTESHIM LTD
摘要:A process for preparation of a compound of formula (I) in which R is hydrogen, hydroxyl, C1-C10 -alkyl, C1-C10 -alkoxy, C1-C4 -alkylamino, di- C1-C4 - alkylamino, C1-C4 -acylamino, COOR1, — CH2— R2 where R1 is hydrogen or C1-C4 -alkyl or R2—CH2— and R2 is hydroxyl, C1-C4 -alkoxy, C1-C4 -alkylamino or di- C1-C4 -alkylamino; n represents the number of carbon atoms and is any integer of 0, 1, 2; and m represents the number of R groups and satisfies the relation: 0≤m≤8+2n. The process comprising: (a) oxidation of a compound of formula (III) wherein R is as defined above, with salt of a hypohalous acid to give compound of the formula (II), wherein R, n and m are as defined above, and X is Cl, Br or I; and (b) hydrolysis in the presence of water of the compound of the formula (II).

专利号:US-4870180-A
优先权日:1986-03-17
标 题 :1,2-dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b)indoles and the process for their synthesis
发明人：BISAGNI EMILE R; NGUYEN HUNG C; DE COINTET PAUL M
权利人:SANOFI AND CENTRE NATIONAL DE
摘要:The present invention relates to new compounds which are the 1,2-dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b)indoles with the formula (I): ##STR1## in which R represents hydrogen or an alkoxy or aryl carbonyloxy group. These compounds are intermediates of synthesis in the preparation of compounds which can be used in the pharamaceutical industry. The invention is also concerned with their synthesis.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.