CAS: 134419-59-3; Tetrahydro-2H-Pyran-4-Yl Methanesulfonate

相似化合物

1909287-40-6 262444-08-6 133243-83-1

上下游产品

CAS号2081-44-9 四氢吡喃-4-醇 | CAS号124-63-0 甲基磺酰氯 | CAS号29943-42-8 四氢吡喃酮 | CAS号108-97-4 4H-吡喃-4-酮 | CAS号1040377-02-3 4-溴-1-(四氢-2H-吡喃... | CAS号203246-70-2 S-(oxan-4-yl) e... | CAS号1040377-03-4 1-(四氢吡喃-4-基)-1H... | CAS号116312-69-7 1-(四氢-2H-吡喃-4-基)肼盐酸盐 | CAS号3174-74-1 3,6-二氢吡喃

📜吡喃-4-酮置于吡啶,镍体系中,化学反应生成4-四氢吡喃基 甲磺酸酯
参考文献:164.四氢吡喃-3:4-二醇和四氢-2:2:5:5-四甲基呋喃-3:4-二醇
标题:164.四氢吡喃-3:4-二醇和四氢-2:2:5:5-四甲基呋喃-3:4-二醇
摘要:
Doi:10.1039/jr9520000910

专利信息

专利号:US-12384788-B2
优先权日:2019-09-13
标 题 :1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
发明人：KOESTLER ROLAND; TASSEL JEAN; THORMANN MICHAEL; YEHIA NASSER; TREML ANDREAS; ALMSTETTER MICHAEL
权利人:ORIGENIS GMBH
摘要:The present invention relates to compounds of formula (I) that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 40 to 146; examples 1 to 63; compounds 1 to 248; tables 1 to 3). Preferred compounds are e.g. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds. An exemplary compound is e.g. 5-(2,6-difluorophenyl)-8-methoxy-1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine (example 49). (Formula (II):

专利号:US-9051289-B2
优先权日:2013-09-26
标 题 :Process and intermediates for preparing GPR40 agonists
发明人：DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN
权利人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I n nwherein R S denotes F or CF 3 , R a denotes H or C 1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.

专利号:US-10988466-B2
优先权日:2017-03-23
标题:Heterocyclic derivatives useful as SHP2 inhibitors
发明人：MA CUNBO; GAO PANLIANG; HU SHAOJING; XU ZILONG; HAN HUIFENG; WU XINPING; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.