专利号:WO-2023058037-A1 优先权日:2021-10-05 标 题 :Biomolecule mixture for biogenic synthesis of metal nanoparticles 发明人:PAWAR KIRAN D; Desai Megha Prakash 权利人:SHIVAJI UNIV 摘要:The present invention relates to a method for preparation of biomolecule mixture in dried/freeze-dried form using bacterial strains selected from the group comprising Lysinibacillus xylanilyticus, Lysinibacillus sp, Lysinibacillus pakistanensis and Lysinibacillus macroides for simple and rapid biogenic synthesis of metal nanoparticles namely gold, silver, palladium and platinum nanoparticles. The method of preparation includes growing the bacterial strain, harvesting the biomass, centrifugation, washing, re- suspension, and incubation, collection of homogenate, centrifugation, collection of biomolecule mixture, precipitation, incubation, centrifugation, dissolution, dialysis, and freeze drying biomolecule mixture and the use of biomolecules mixtures for simple and rapid biogenic synthesis of gold, silver, palladium and platinum nanoparticles at broad range of reaction parameters such as reaction volume, concentration of biomolecule mixture and metal precursor, pH; incubation and reaction time.
专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10973847-B2 优先权日:2017-06-30 标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof 发明人:JOHNSON JEREMIAH A; GOLDER MATTHEW R 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.
专利号:WO-9747313-A1 优先权日:1996-06-10 标题:Total synthesis of bacitracin polypetides 发明人:GRIFFIN JOHN H; MCDOUGAL PATRICK G 权利人:UNIV LELAND STANFORD JUNIOR 摘要:Methods for the total synthesis of bacitracin-type polypeptides are described, as well as useful analogs of bacitracin A, and treatment of bacterial infection using such analogs.
专利号:US-9549995-B2 优先权日:2012-03-26 标 题:Efficient synthesis of ethylenedicysteine-sugar conjugates for imaging and therapy 发明人:YANG DAVID J; YU DONG-FANG 权利人:UNIV TEXAS 摘要:Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:WO-2017100796-A1 优先权日:2015-12-11 标 题 :Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers 发明人:WONG CHI-HUEY; HSU TSUI-LING; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI 权利人:SINACA ACAD; WONG CHI-HUEY; HSU TSUI-LING 摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta- 4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.
1: Li CH, Kuo TR, Su HJ, Lai WY, Yang PC, Chen JS, Wang DY, Wu YC, Chen CC. Fluorescence-Guided Probes of Aptamer-Targeted Gold Nanoparticles with Computed Tomography Imaging Accesses for in Vivo Tumor Resection. Sci Rep. 2015 Oct 28;5:15675. doi: 10.1038/srep15675. 2: Kleywegt S, Pileggi V, Lam YM, Elises A, Puddicomb A, Purba G, Di Caro J, Fletcher T. The contribution of pharmaceutically active compounds from healthcare facilities to a receiving sewage treatment plant in Canada. Environ Toxicol Chem. 2015 Jun 22. doi: 10.1002/etc.3124. [Epub ahead of print] doi: 10.1016/j.envpol.2014.11.033. Epub 2015 Jan 13. doi: 10.1002/chem.201404693. Epub 2014 Nov 4. doi: 10.1016/j.aca.2014.05.055. Epub 2014 Jun 4. doi: 10.1016/j.scitotenv.2014.04.063. Epub 2014 May 11. doi: 10.1016/j.scitotenv.2014.02.139. Epub 2014 Mar 22. doi: 10.1007/s00216-014-7712-0. Epub 2014 Mar 4. doi: 10.1016/j.talanta.2013.07.080. Epub 2013 Aug 9. doi: 10.1039/c2cc35995b. Epub 2012 Nov 8.
合成参考文献
参考文献:10.1001/archsurg.2009.274 摘要:Edelman DA, Laker S, Weiner M, Webber JD. Routine postoperative gastrografin studies are not necessary after laparoscopic gastric banding. Arch Surg. 2010 Feb;145(2):211–2; author reply 212. doi: 10.1001/archsurg.2009.274. 参考文献:10.1155/2011/384143 摘要:Kouklakis G, Zezos P, Liratzopoulos N, Gatopoulou A, Oikonomou A, Pitiakoudis M, Efremidou E, Simopoulos C. Endoscopic Treatment of a Gastrocutaneous Fistula Using the Over-The-Scope-Clip System: A Case Report. Diagnostic and Therapeutic Endoscopy. 2011 May 29;2011():1–5. doi: 10.1155/2011/384143. 参考文献:10.1155/2011/146865 摘要:Saito M, Nemoto T, Tobimatsu S, Ebata M, Le Y, Nakajima K. Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial. Journal of Nutrition and Metabolism. 2011;2011():1–7. doi: 10.1155/2011/146865.