专利号:WO-2012095438-A1 优先权日:2011-01-12 标 题 :Particles and suspensions of cephalosporin antibiotics 发明人:NIEDERMANN HANS PETER; BOTHE HEIKO 权利人:INTERVET INT BV; NIEDERMANN HANS PETER; BOTHE HEIKO 摘要:Disclosed is a method of making particles of a cephalosporin antibiotic, particularly cefquinome, wherein use is made of diafiltration. The diafiltration can be with anti- solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.
专利号:US-9066864-B2 优先权日:2011-01-12 标 题:Use of liquid medium exchange by cross flow filtration in the preparation of drug suspensions 发明人:NIEDERMANN HANS PETER; BOTHE HEIKO 权利人:NIEDERMANN HANS PETER; BOTHE HEIKO; INTERVET INC 摘要:Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.
专利号:WO-2020024500-A1 优先权日:2018-08-02 标 题 :Synthesis method for low-transoleate content polysorbate 80 for injection 发明人:WU MINGLANG; FU XIN; ZHU BING; PAN JINGJING; GAO ZHENGSONG; SHI CHEN; WANG BAOCHENG; LI HONGLI; WU YANGBO 权利人:NANJING WEIER PHARMACEUTICAL CO LTD 摘要:A synthesis method for low-transoleate content polysorbate 80 for injection, comprising the following synthesis steps: mixing polyoxyethylene (20) sorbitol anhydride and high-purity low-carbon oleic acid alcohol ester according to a certain ratio, performing transesterification reaction under the action of a catalyst and in vacuum, and then performing refinement, sterilization, and removal of a pyrogen to obtain the polysorbate 80 for injection. The mass ratio of the polyoxyethylene (20) sorbitol anhydride to the high-purity low-carbon oleic acid alcohol ester ranges from 1:0.3 to 1:0.5. Compared with other methods, the method has the advantages as follows: the reaction temperature is lowered, conversion between cis-trans isomers of the oleic acid is effectively inhibited, so that the content of transoleate in the polysorbate 80 is reduced to be lower than or equal to 0.3%, and the chroma (APHA) is reduced to be lower than or equal to 30, and the biosafety of the polysorbate 80 is improved, moreover, the process operations are simplified, the process production efficiency is improved, and the production costs are reduced.
专利号:WO-2020244507-A1 优先权日:2019-06-06 标题:Use of nicotinamide mononucleotide and/or nicotinamide mononucleotide salt 发明人:CHEN JIANSHENG 权利人:HOBOOMLIFE BIO TECH SHENZHEN CO LTD 摘要:The present invention relates to the field of medicament and health food research and development, and in particular to use of a nicotinamide mononucleotide and/or a nicotinamide mononucleotide salt. Provided is use of a nicotinamide mononucleotide or a nicotinamide mononucleotide salt in preparation of anti-allergic medicaments and/or anti-allergic health care products. In the technical solution, using the nicotinamide mononucleotide or the nicotinamide mononucleotide salt can induce Treg cells to secrete immunosuppressive cytokines IL10, TGF-β and the like, so as to inhibit the immune response of TH2, blood basicytes and tissue mast cells, reduce sIgE synthesis, increase sIgG and sIgA synthesis at the same time, and finally alleviate allergic symptoms. Further, it can be found through experiments that after using the nicotinamide mononucleotide and/or the nicotinamide mononucleotide salt, there are fewer adverse reactions and allergy recurrence rate is reduced. Provided is use of the nicotinamide mononucleotide and/or the nicotinamide mononucleotide salt for solving the technical defects in the prior art that antiallergic medicament have some adverse reactions and need to be used repeatedly and allergies tend to recur.
专利号:CN-104910009-A 优先权日:2015-06-25 标题 :A kind of method of ionic liquid catalyzed synthesis of pletil alcohol ester
专利号:CN-1539811-A 优先权日:2003-10-28 标题:SO42ï¼?/TiO2 Solid Superacid Catalytic Synthesis of Ethyl Linoleate
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合成参考文献
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