专利号:US-2023151394-A1 优先权日:2020-03-31 标题 :Biologic synthesis of diols from amino acids 发明人:ZENG AN-PING; LIU YONGFEI 权利人:TAIZHOU SIMPLU TECH CO LTD 摘要:A method for the enzymatically catalyzed synthesis of a diol from an amino acid includes enzymatically hydroxylating the amino acid, enzymatically deaminating the amino acid, the deamination resulting in the formation of an oxo group at the position of the amino group, enzymatically decarboxylating the amino acid, and enzymatically hydrogenating the oxo group resulting from the deamination reaction.
专利号:US-2012094919-A1 优先权日:2009-03-16 标题 :Use of tripeptides 发明人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.
专利号:WO-2008136037-A3 优先权日:2007-05-04 标 题:Chemical-catalytic method for the peracylation of oleuropein and its products of hydrolysis 发明人:PROCOPIO ANTONIO; SINDONA GIOVANNI; COSTA NICOLA; GASPARI MARCO; NARDI MONICA 权利人:UNI DEGLI STUDI MAGNA GRAECIA; UNIV CALABRIA; PROCOPIO ANTONIO; SINDONA GIOVANNI; COSTA NICOLA; GASPARI MARCO; NARDI MONICA 摘要:The method, object of the present invention, concerns the peracylation of oleuropein and its products of hydrolysis: The method makes use of the excellent properties as Lewis acid catalysts of halides and tryphilates of lanthanides (III). The component is placed to react, in the presence of catalytic quantities of Lewis acid, directly with an acylating agent containing at least one acylic group R, where R is H, an alkylic radical of 1-31 atoms of linear or branched carbon, an alkenylic radical containing up to 31 atoms of carbon or an arylic group. The procedures for the extraction and the successive hydrolysis of the oleuropein for the synthesis of its aglycon and the hydroxytyrosol, resolve the problems tied to the quantitative yield of the products and to the use of highly-toxic and expensive catalysts. Furthermore, the innovative and inventive contribution is given by the peracylation of the oleuropein and its products of synthesis, aglycon and hydroxytyrosol, that supply a new class of molecule, biologically active as anti-oxidants and anti-inflammatory ones. The proven anti-oxidant activity of oleuropein and its derivates leads to the hypothesis that they could also act as protectors against oxidative stress at the level of the central nervous system, one of the causal factors of Parkinson's disease. The molecules examined are all good protectors against oxidative stress and the greater efficiency of the peracylated derivatives is presumably due to their greater lipophilicity and the possibility of penetrating the cellular membrane.
专利号:US-2010143990-A1 优先权日:2006-11-27 标 题 :Fermentative production of hydroxytyrosol 发明人:ACHKAR JUEHANE; FERRANDEZ ABEL 权利人:ACHKAR JUEHANE; FERRANDEZ ABEL 摘要:The present invention relates to a newly identified microorganisms capable of direct production of hydroxytyrosol (hereinafter also referred to as Hy-T) from a carbon source obtainable from the D-glucose metabolization pathway. The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Hy-T. The invention also relates to genetically engineered microorganisms and their use for the direct production of Hy-T.
专利号:US-2014357576-A1 优先权日:2013-05-31 标题:Methods for enhancement of muscle protein synthesis 发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN 权利人:NESTEC SA 摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.
专利号:WO-2015040533-A1 优先权日:2013-09-19 标题:Methods for enhancing muscle protein synthesis during energy deficit 发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY 权利人:PREMIER NUTRITION CORP 摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.
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