CAS: 1011-92-3; 2-Cyano-3-Phenylacrylic Acid

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2700-22-3 148238-25-9 584-45-2

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CAS号100-52-7 苯甲醛 | CAS号372-09-8 氰基乙酸 | CAS号105-56-6 氰乙酸乙酯 | CAS号4360-49-0 α-Hydroxymethyl... | CAS号139413-81-3 2-(bromomethyl)... | CAS号120-92-3 环戊酮 | CAS号96-15-1 2-甲基丁胺 | CAS号593-51-1 一甲胺盐酸盐 | CAS号142-04-1 苯胺盐酸盐 | CAS号3695-84-9 2-氰基-3-苯基丙烯酸甲酯 | CAS号141-82-2 丙二酸 | CAS号7664-41-7 氨 | CAS号100-52-7 苯甲醛 | CAS号4360-47-8 3-苯基丙烯腈 | CAS号124-38-9 二氧化碳 | CAS号635-51-8 苯基丁二酸 | CAS号5331-42-0 2-氰基-3-苯基丙酸 | CAS号102-93-2 3-苯基丙酰胺 | CAS号372-09-8 氰基乙酸

📜苯甲醇置于哌啶,Sodium Hypochlorite,2,2,6,6-四甲基哌啶氧化物,碳酸氢钠,Potassium Bromide体系中,用 二氯甲烷,水 用作溶剂,100.0 °C,600.01 Kpa 条件下,反应 1.21H,反应生成α-氰基肉桂酸
参考文献:化学组装系统:活性药物成分的分散,连续,多步合成的分层控制
标题:化学组装系统:活性药物成分的分散,连续,多步合成的分层控制
摘要:尽管连续化学过程吸引了学术界和工业界的兴趣,但实际上所有活性药物成分(api)仍是通过使用多个不同的批处理过程来生产的.迄今为止,还没有用于可定制的小分子的不同的多步连续生产的方法.开发了一种化学装配系统,该系统中的流动反应模块以可互换的方式链接在一起,从而可以访问广泛的化学空间.在三个不同级别上进行控制-原料,试剂或反应模块的顺序选择-可以合成代表三个不同结构类别(γ-氨基酸,γ-内酰胺,β-氨基酸)的五个api,包括大片药物lyrica和gabapentin,总收率非常好(49-75%).
Doi:10.1002/anie.201409765

专利信息

专利号:US-4567265-A
优先权日:1984-01-16
标题:Cyclopropanoid cyanoesters and method of making same
发明人：BABLER JAMES H
权利人:UNIV LOYOLA CHICAGO
摘要:Cyclopropanoid cyanoesters of the formula: where R' is -CH3 or -CH2CH3, and A is (a) -H, or (b) A, B represents an aliphatic group joined to a carbon atom on the cyclopropanoid ring, thereby forming a spiro group, A, B being selected from structures having the formula: (i) -(CH2)n-, wherein n=3, 4, or 5, and (ii) -(CH2)2-Y-(CH2)2-, wherein Y is NCH3, O, or S); and, when A is -H, B is selected from the group consisting of: +TR (CH3)2CHCH2. are disclosed. These compositions are useful in the synthesis of pyrethroids. A process for synthesis of cyclopropanoid cyanoesters by reacting 2-nitropropane with cyanoesters of the general formula: is also disclosed and claimed.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-113149865-B
优先权日:2021-04-07
标题 :Preparation method and application of organic basic catalyst for catalytic synthesis of alpha-cyano ethyl cinnamate

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-2023103693-A1
优先权日:2019-12-20
标 题 :Synthesis of compounds to promote hair growth