CAS: 913835-28-6; (3-(N-Cyclopropylsulfamoyl)Phenyl)Boronic Acid
该化合物是一种有机化合物,其特点是,在苯环上有一个附于苯环的碱酸功能组,该组又被一个环丙丙丙基硫磺酰基组取代.该化合物通常具有与黄酸相关的特性,例如能够与二醇形成可逆的共价联系,使其在各种应用中,包括有机合成和药用化学中有用.环丙丙基磺酰胺基可产生独特的生物活动,有可能增强其在药物开发中的效用.该化合物在室温下很固,由于黄酸组的存在,极地溶剂中溶性很强.其再活性可能受到亚基组体的电子和...
- 英文名称(3-(N-Cyclopropylsulfamoyl)Phenyl)Boronic Acid
- 中文名称(3-(正环丙基氨磺酰基)苯基)硼酸
- IUPAC名称(3-(N-cyclopropylsulfamoyl)phenyl)boronic acid
- 其它别名(3-(N-环丙基氨磺酰)苯基)硼酸; 3-(N-Cyclopropylsulphamoyl)Benzeneboronic Acid
- CAS编号913835-28-6
- MFCD编号:MFCD08436035
- 分子式:C9H12BNO4S分子量:241.08
- 产品CID: 1949368
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
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MSDS等安全信息
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海关参考信息
- 2902200000-苯
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专利信息
专利号:US-2009227575-A1
优先权日:2008-03-04
标 题 :7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS
发明人：VENKATESAN ARANAPAKAM MUDUMBAI; CHEN ZECHENG; DOS SANTOS OSVALDO; BROOIJMANS NATASJA; GOPALSAMY ARIAMALA
权利人:WYETH CORP
摘要:A 7H-pyrrolo[2,3-h]quinazoline compound of the formula I n n n n n n n n n n wherein Ar, R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and n are as defined in the specification, and methods for making same.
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主要参考文献
参考标题:Modular Synthesis Of Di- And Trisubstituted Imidazoles From Ketones And Aldehydes: A Route To Kinase Inhibitors作者:Ian De Toledo,Thiago A. Grigolo,James M. Bennett,Jonathan M. Elkins,Ronaldo A. Pilli |发布日期:2019.11.1
摘要:A One-Pot And Modular Approach To The Synthesis Of 2,4(5)-Disubstituted Imidazoles Was Developed Based On Ketone Oxidation, Employing Catalytic Hbr And Dmso, Followed By Imidazole Condensation With Aldehydes. This Methodology Afforded Twenty-Nine Disubstituted Nh-Imidazoles (23%-85% Yield). A Three-Step Synthesis Of 20 Kinase Inhibitors Was Achieved By Employing This Oxidation-Condensation Protocol
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