CAS: 7782-95-8; Disodium Diphosphate

专利信息

专利号:US-4814500-A
优先权日:1986-09-01
标 题:Cyanoguanidine derivative and process for preparation thereof
发明人：KIHARA NORIAKI; MUKAIYAMA TERUAKI; ISHITOKU TAKESHI; TAKAHASHI KATSUYA
权利人:MITSUI PETROCHEMICAL IND
摘要:A novel cyanoguanidine derivative represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N'-(2-(5-methyl-4-imidazolylmethylthio(ethyl)-guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer. n This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.