CAS: 759-65-9; Diethyl 2-Methyl-3-Oxosuccinate

该化合物是一种多用途酯化合物,广泛用作有机合成的中间体,其结构以keto和ester功能组为特点,对制造复杂的分子,特别是制药和精细化学品中的复杂分子很有价值.该化合物在凝聚和电温反应中表现出良好的反应性,能够有效地衍生.在标准条件下保持稳定,普通有机溶剂中具有中度溶解性,有利于实验室和工业环境中的处理.甲基组的存在加强了某些变异中的选择性,使其成为定向合成途径的首选试剂.建议在无水条件下适当储存,以保持其完整性.

结构式图片

相似化合物

89073-66-5 108-56-5 93504-92-8

欧盟法规

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上下游产品

CAS号105-37-3 丙酸乙酯 | CAS号95-92-1 草酸二乙酯 | CAS号74-88-4 碘甲烷 | CAS号60-29-7 乙醚 | CAS号917-58-8 乙醇钾 | CAS号141-52-6 乙醇钠 | CAS号10028-15-6 臭氧 | CAS号27772-62-9 2-甲酰基丙酸乙酯 | CAS号51673-64-4 methyl 3-oxoiso... | CAS号3952-66-7 2-氧代丁酸甲酯 | CAS号20201-24-5 3-甲基-2-氧代丁酰乙酯 | CAS号219949-95-8 3-甲基-4-羟基喹喔啉-2-羧酸乙酯 | CAS号28664-37-1 3-hydroxy-4-met... | CAS号609-02-9 甲基丙二酸二甲酯 | CAS号6065-52-7 1-O-ethyl 3-O-m... | CAS号201230-82-2 carbon monoxide | CAS号99380-59-3 1-O-ethyl 4-O-m...

合成工艺路线路线简述

    📜丙酸乙酯,草酸二乙酯置于sodium Ethanolate体系中,用 乙醇 作为反应溶剂,以67%的收率获得产物草酰丙酸二乙酯
    参考文献: Condensed Azaheteroaryl Compounds Having Antibacterial Activity Against Tuberculosis Bacteria[fr] Composés Azahétéroaryles Condensés Ayant Une Activité Antibactérienne Contre Les Bactéries De La Tuberculose
    标题: Condensed Azaheteroaryl Compounds Having Antibacterial Activity Against Tuberculosis Bacteria[fr] Composés Azahétéroaryles Condensés Ayant Une Activité Antibactérienne Contre Les Bactéries De La Tuberculose
    摘要:本发明涉及一般式(i)的新化合物,它们的对映体,非对映体,药学上可接受的盐或其前药,适用于治疗细菌感染.一般式(i)的化合物表现出dpre1酶抑制活性.

    海关参考信息

    专利信息


    专利号:US-11939325-B2
    优先权日:2020-07-27
    标 题 :Process for making biologically active compounds and intermediates thereof
    发明人:MAKRIYANNIS ALEXANDROS; VEMURI KIRAN
    权利人:MAKSCIENTIFIC LLC
    摘要:A process of manufacturing biologically active compounds, their analogs, pharmaceutically acceptable salts, solvates, polymorphs, isotopic variants, and intermediates thereof. Notably, the compounds of the formula IA, 1B, 1C. 1D. 1E, 1F and IG for which novel processes have been disclosed, selectively act on the cannabinoid receptors, and with high affinity. The processes for the preparation of the compounds enable the syntheses of cannabinoid modulators on a large-scale that are eco-friendly and economically viable. Additionally, the processes disclosed enable the synthesis of cannabinoid modulators with high purity and in high yield for their use in making drug substance and drug products.

    专利号:US-2011296543-A1
    优先权日:2006-06-01
    标题:Nucleic acids and proteins and methods for making and using them
    发明人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON
    权利人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON; UNIV CALIFORNIA; CALIFORNIA INST OF TECHN; VERENIUM CORP
    摘要:The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs. Polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to a biofuel (e.g., a bioethanol, biomethanol, biopropanol or biobutanol, a biodiesel, etc.), biodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.

    专利号:US-2024368378-A1
    优先权日:2021-08-30
    标 题 :Process for improving resin performance
    发明人:SIMPSON NEIL JOHN; NEHACHE SABRINA; MENZEL CLAUDIA
    权利人:BORCHERS GMBH
    摘要:The invention pertains generally to a process and resulting product of following the steps of the process involving adding an Iron- or Manganese- or Vanadium- or Copper- in combination with a multidentate ligand to form a metal-ligand complex with a thiol or polythiol to an alkyd resin, said steps performed in any order or the synthesis performed in-situ.

    专利号:RU-2125047-C1
    优先权日:1991-02-07
    标 题:N-derivatives of quinoline or their additive salts with inorganic or organic acids or with inorganic and organic bases, methods of their synthesis and pharmaceutical composition based on them

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 29.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 168.
    摘要:P. Rumpf, Colloques intern. centre natl. recherche sci. l’hydroxycarbonylation, Paris 56, 14 (1954)(publ. 1955); CA 50, 11776i.
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