📜丙酸乙酯,草酸二乙酯置于sodium Ethanolate体系中,用 乙醇 作为反应溶剂,以67%的收率获得产物草酰丙酸二乙酯 参考文献: Condensed Azaheteroaryl Compounds Having Antibacterial Activity Against Tuberculosis Bacteria[fr] Composés Azahétéroaryles Condensés Ayant Une Activité Antibactérienne Contre Les Bactéries De La Tuberculose 标题: Condensed Azaheteroaryl Compounds Having Antibacterial Activity Against Tuberculosis Bacteria[fr] Composés Azahétéroaryles Condensés Ayant Une Activité Antibactérienne Contre Les Bactéries De La Tuberculose 摘要:本发明涉及一般式(i)的新化合物,它们的对映体,非对映体,药学上可接受的盐或其前药,适用于治疗细菌感染.一般式(i)的化合物表现出dpre1酶抑制活性.
专利号:US-11939325-B2 优先权日:2020-07-27 标 题 :Process for making biologically active compounds and intermediates thereof 发明人:MAKRIYANNIS ALEXANDROS; VEMURI KIRAN 权利人:MAKSCIENTIFIC LLC 摘要:A process of manufacturing biologically active compounds, their analogs, pharmaceutically acceptable salts, solvates, polymorphs, isotopic variants, and intermediates thereof. Notably, the compounds of the formula IA, 1B, 1C. 1D. 1E, 1F and IG for which novel processes have been disclosed, selectively act on the cannabinoid receptors, and with high affinity. The processes for the preparation of the compounds enable the syntheses of cannabinoid modulators on a large-scale that are eco-friendly and economically viable. Additionally, the processes disclosed enable the synthesis of cannabinoid modulators with high purity and in high yield for their use in making drug substance and drug products.
专利号:US-2011296543-A1 优先权日:2006-06-01 标题:Nucleic acids and proteins and methods for making and using them 发明人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON 权利人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON; UNIV CALIFORNIA; CALIFORNIA INST OF TECHN; VERENIUM CORP 摘要:The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs. Polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to a biofuel (e.g., a bioethanol, biomethanol, biopropanol or biobutanol, a biodiesel, etc.), biodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.
专利号:US-2024368378-A1 优先权日:2021-08-30 标 题 :Process for improving resin performance 发明人:SIMPSON NEIL JOHN; NEHACHE SABRINA; MENZEL CLAUDIA 权利人:BORCHERS GMBH 摘要:The invention pertains generally to a process and resulting product of following the steps of the process involving adding an Iron- or Manganese- or Vanadium- or Copper- in combination with a multidentate ligand to form a metal-ligand complex with a thiol or polythiol to an alkyd resin, said steps performed in any order or the synthesis performed in-situ.
专利号:RU-2125047-C1 优先权日:1991-02-07 标 题:N-derivatives of quinoline or their additive salts with inorganic or organic acids or with inorganic and organic bases, methods of their synthesis and pharmaceutical composition based on them