CAS: 6937-34-4; 3-Iodophthalic Acid

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CAS号5434-20-8 3-氨基苯二甲酸 | CAS号102928-38-1 3-碘邻苯二甲酸二甲酯 | CAS号31599-60-7 3-碘邻二甲苯 | CAS号603-11-2 3-硝基邻苯二甲酸 | CAS号13365-26-9 3-硝基邻苯二甲酸二甲酯 | CAS号24564-71-4 1,2-BENZENEDICA... | CAS号34529-06-1 3-氨基邻苯二甲酸二甲酯 | CAS号58142-99-7 5-碘异喹啉 | CAS号67193-50-4 3-iodo-phthalic... | CAS号62351-80-8 1,2-Benzenedica... | CAS号105694-46-0 7-碘异苯并呋喃-1(3H)-酮 | CAS号28418-88-4 3-碘邻苯二甲酸酐 | CAS号88-99-3 邻苯二甲酸

1,2-二甲基-3-碘苯置于potassium Permanganate,Sodium Hydroxide,盐酸体系中,用 水 作为反应溶剂,化学反应 0.08H,以3.94 G的收率获得产物3-碘苯二甲酸
参考文献:New Thalidomide Analogues Derived Through Sonogashira Or Suzuki Reactions And Their Tnf Expression Inhibition Profiles
标题:New Thalidomide Analogues Derived Through Sonogashira Or Suzuki Reactions And Their Tnf Expression Inhibition Profiles
摘要:A Library Of New Thalidomide C4/5 Analogues Containing Either A Phenyl Or Alkyne Tether Were Synthesized Using Sonogashira Or Suzuki Cross Coupling Reactions From Their Aryl Halogenated Precursors. All Thalidomide Analogues Were Tested For Their Ability To Inhibit The Expression Of The Proinflammatory Cytokine Tumor Necrosis Factor (Tnf). More Explicitly The Use Of A Novel Reporter System Utilizing The Promoter Region Of The Tnf Gene In A Human T-Cell Line Provided A Rapid And Effective Measure Of Nf Kappa B Transcriptional Activity. Several Compounds Either Containing Either An Aryl-Isobutyl Or Aryl-Isopropoxy Group Were The Most Effective In Inhibiting Tnf Expression,And Were Several Times More Active Than Thalidomide Itself. Five Of The More Active Derivatives Indicated An Apoptotic Response While One Of These Compounds,Containing An Aldehyde Tether,Showed Possible Influence Of Cell Cycling Effects. (C) 2009 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2009.12.001

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6933405-B2
优先权日:2002-07-31
标题 :User- and eco-friendly hypervalent iodine reagent and method of synthesis
发明人：VINOD THOTTUMKARA K; THOTTUMKARA ARUN P
权利人:TRUSTEES OF WESTERN ILLINOIS U
摘要:The present invention is a user- and eco-friendly hypervalent iodine reagent (mIBX) capable of selectively oxidizing allylic and benzylic alcohols in water and other eco-friendly solvents and having generally the following structure: n n nAllylic and benzylic alcohols are cleanly oxidized to the corresponding carbonyl compounds in water or water-THF mixtures, or other mixtures, using a water-soluble o-iodoxybenzoic acid derivative of the present invention.

专利号:US-6770586-B2
优先权日:2000-04-24
标题 :Solid catalyst component and catalyst for olefins polymerization
发明人：TASHINO KUNIHIKO; SUZUKI YUKIHIRO; NISHIYAMA ISA; OGAWA HAYASHI; YOSHIDA TAKUMA; HOSAKA MOTOKI; SATO MAKI
权利人:TOHO TITANIUM CO LTD
摘要:Solid catalyst components and catalysts which contain (a) magnesium compound, (b) titanium tetrachloride, and (c) a phthalic acid diester or its derivative are useful in the synthesis of olefin polymers in high yields. Particularly, propylene polymers can be obtain in very high yields while retaining high stereoregularity.

专利号:US-7199128-B2
优先权日:2005-02-02
标题 :8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
发明人：BRADBURY BARTON J; WILES JASON ALLAN; DESHPANDE MILIND; WANG QIUPING; HASHIMOTO AKIHIRO; LUCIEN EDLAINE
权利人:ACHILLION PHARMACEUTICALS INC
摘要:The invention provides compounds and salts of Formula I and Formula II: n nwhich possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A 1 , A 8 , R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 are defined herein.n n Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.

专利号:US-2004030187-A1
优先权日:2002-07-31
标题:User- and eco-friendly hypervalent iodine reagent and method of synthesis