CAS: 6639-57-2; 1,3-Benzothiazole-2-Carbaldehyde

上下游产品

2-Methylbenzothiazole 1,3-benzothiazol-2-ylmethanol 3-benzothiazol-2-yl-acrylic acid N'-benzothiazol-2-ylmethylene-N,N-dimethyl-benzene-1,4-diamine N'-oxideN'-benzothiazol-2-ylmethylene-N,N-dimethyl-benzene-1,4-diamine N'-oxideN'-benzothiazol-2-ylmethylene-N,N-dimethyl-benzene-1,4-diamineN'-benzothiazol-2-ylmethylene-N,N-dimethyl-benzene-1,4-diamine benzothiazol-2-ylmethylen-aniline 2-benzothiazol-2-ylmethyleneamino-phenol benzothiazole-2-carbaldehyde (4-nitro-phenyl)-hydrazone

苯并噻唑置于iron(II) Triflate,盐酸,叔丁基过氧化氢体系中,用 癸烷,水,1,2-二氯乙烷,丙酮 作为反应溶剂,化学反应 32.0H,反应生成 苯并噻唑-2-甲醛
参考文献:铁催化串联氧化偶联和乙缩醛水解反应制备甲酰化苯并噻唑和异喹啉
标题:铁催化串联氧化偶联和乙缩醛水解反应制备甲酰化苯并噻唑和异喹啉
摘要:醛基是合成化学中最通用的中间体之一,并且将醛基引入杂芳烃对于分子结构的转化很重要.在这里,我们实现了苯并噻唑/莱和异喹啉的直接甲酰化.该反应具有新颖的铁催化的minisci型氧化偶联工艺,该工艺使用可商购的1,3-二氧戊环作为甲酰化试剂,然后进行乙缩醛水解而无需分离过程.该反应可以在非常温和的反应条件下进行,并且表现出宽泛的官能团耐受性.
DOI:10.1039/d1Cc00621E

专利信息

专利号:US-7612106-B2
优先权日:2004-12-23
标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
发明人：BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU
权利人:ARENA PHARM INC
摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

专利号:US-2024002405-A1
优先权日:2022-06-01
标题 :Antimicrobial compounds, synthesis methods, and uses thereof
发明人：VERMA RAJNI; DONAVALLI KRISHNA MOHAN; ZAID GENE H
权利人:ANKH LIFE SCIENCES LTD
摘要:Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.

专利号:US-2011224442-A1
优先权日:2010-02-26
标 题 :Methods and systems for synthesis of a d-aminoluciferin precursor and related compounds

专利号:CN-106632139-A
优先权日:2016-12-13
标 题 :A New Method for the Synthesis of Benzothiazole-2-Carboxaldehyde and Its Derivatives

专利号:US-2011213124-A1
优先权日:2010-02-26
标 题:Methods and systems for synthesis of a d-aminoluciferin precursor and related compounds

专利号:WO-0004007-A1
优先权日:1998-07-17
标 题 :Fluorescent dibenzazole derivatives and methods related thereto
发明人：BROWN LAUREN R; XU CHENG
权利人:PROMEGA BIOSCIENCES INC
摘要:Dibenzazole compounds having general structure (I and II), wherein: R1, R2, R3, R4, R5, R6 are independently H or a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety; Y is H or a cleavable moiety; X is a hydrogen, halogen, CF3, or SO3H; V and W are oxygen or sulfur; Z is -C=C-, -C C- or an aromatic ring moiety; and n is 0, 1, or 2. When n=0 at least one of R1, R2, R3, R4, and R5 is a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety or X is a halogen, CF3 or SO3H. These compounds are highly fluorescent and can be easily detected using a fluorometer. Derivatives in which the Y group is a substituent other than H contain a fluorescence inhibiting chemical moiety that upon removal restores the fluorescence of the compound. Methods for their synthesis and application are provided.