CAS: 51166-71-3; 2,6-Di-O-Methyl-ß-Cyclodextrin

该化合物是一种经修改的环己衍生物,在葡萄糖单位的2和6个氢氧位置上有选择性地进行甲基化,这种部分甲基化会提高水溶剂和有机溶剂的溶性,同时保留本地β-环十二烯菊酯的宿主-座标复合特性.90%纯度能确保药物溶解,手艺分离和敏感化合物稳定等应用的一贯性.其溶解性特征的改善使其在需要更高浓度或与缺水亚体相容的配方中特别有用.该产品适合于药物,分析和化学研究,在衍生利益与保存的导体功能之间实现平衡.

结构式图片

相似化合物

55216-11-0 68715-56-0 111689-03-3

上下游产品

CAS号114797-69-2 Heptakis(2,6-di... | CAS号77-78-1 硫酸二甲酯 | CAS号7585-39-9 β-环糊精 | CAS号17465-86-0 γ-环糊精 | CAS号74-88-4 碘甲烷 | CAS号120309-61-7 | CAS号120309-63-9 | CAS号128443-52-7 (5R,5aR,8aR,9R)...

合成工艺路线路线简述

  • 合成目标产物 2,6-Di-O-Methyl-Beta-Cyclodextrin 主要起始原料 β-Cyclodextrin, 2A,2B,2C,2D,2E,2F,2G,6A,6B,6C,6D,6E,6F,6G-Tetradeca-O-Methyl-3A,3B,3C,3D,3E,3F,3G-Heptakis-O-(Phenylmethyl)- (9CI)
  • (文献来源)合成步骤主要原料 β-Cyclodextrin, 2A,2B,2C,2D,2E,2F,2G,6A,6B,6C,6D,6E,6F,6G-Tetradeca-O-Methyl-3A,3B,3C,3D,3E,3F,3G-Heptakis-O-(Phenylmethyl)- (9Ci)
Heptakis(3-O-Benzyl-2,6-Di-O-Methyl)-β-Cyclodextrin置于palladium On Activated Charcoal 氢气体系中,用 甲醇,溶剂黄146 作为反应溶剂,以93%的收率获得产物二甲基环糊精
参考文献:A Convenient Preparation Of Per-2,6-Di-O-Methylcyclomalto-Oligosaccharides
标题:A Convenient Preparation Of Per-2,6-Di-O-Methylcyclomalto-Oligosaccharides
摘要:
DOI:10.1016/0008-6215(90)84214-F

专利信息


专利号:WO-2024057083-A1
优先权日:2022-11-28
标 题 :Process for the synthesis of selectively alkylated cyclodextrins
发明人:IVÃ?NYI RÓBERT; TUZA KATA; SZENTE LAJOS; PUSKÃ?S ISTVÃ?N; SZÅ?CS LEVENTE; KURKAYEV ABDULA
权利人:CYCLOLAB CYCLODEXTRIN R&D LABORATORY LTD
摘要:The present invention generally relates to a process for the synthesis of selectively alkylated cyclodextrins. More particularly, the present invention relates to a process of cyclodextrin alkylation in a selective manner yielding hexakis(2,6-di-O-alkyl)-alpha-cyclodextrin, heptakis(2,6-di-O-alkyl)-beta-cyclodextrin and octakis(2,6-di-O-alkyl)-gamma-cyclodextrin.

专利号:US-7309591-B2
优先权日:2002-01-24
标 题:Method for the production of resveratrol in cell cultures
发明人:BRU MARTINEZ ROQUE; PEDRENO GARCIA MARIA DEL LOS A
权利人:UNIV ALICANTE
摘要:The invention relates to a method for the production of resveratrol in cell cultures. The inventive method consists in: incubating a culture of cells which produce resveratrol naturally, in suspension, in the presence of randomly-methylated β-cyclodextrin (RMBCD) with a degree of substitution of between 11 and 13 under conditions that allow resveratrol synthesis and the excretion of same into the culture medium; and, if desired, isolating the resveratrol produced from said culture medium. The resveratrol can be used in the production of pharmaceutical or nutraceutical products.

专利号:US-2011256592-A1
优先权日:2008-12-12
标题:Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions
发明人:BECKERS MARIE-CLAIRE; CRONET PHILIPPE; VITALE ADELINE; COLLETTE ERIC; GULLUKAYA ARZU
权利人:EUROGENTEC SA
摘要:The invention is directed to methods for in vitro DNA synthesis catalysed by a DNA polymerase using cyclodextrins. The invention also relates to methods, compositions and kits comprising cyclodextrins for the amplification of a nucleic acid. The use of cyclodextrins improves the specificity, sensibility and/or yield of the amplification reaction. The invention is related more particularly to kits, compositions and methods for carrying out PCR reactions comprising a cyclodextrin.

专利号:EP-2373811-A1
优先权日:2008-12-12
标题 :Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions
发明人:BECKERS MARIE-CLAIRE; CRONET PHILIPPE; VITALE ADELINE; COLLETTE ERIC; GUELLUEKAYA ARZU
权利人:EUROGENTEC SA
摘要:The invention is directed to methods for in vitro DNA synthesis catalysed by a DNA polymerase using cyclodextrins. The invention also relates to methods, compositions and kits comprising cyclodextrins for the amplification of a nucleic acid. The use of cyclodextrins improves the specificity, sensibility and/or yield of the amplification reaction. The invention is related more particularly to kits, compositions and methods for carrying out PCR reactions comprising a cyclodextrin.

专利号:EP-4626935-A1
优先权日:2022-11-28
标题:Process for the synthesis of selectively alkylated cyclodextrins

专利号:US-5403898-A
优先权日:1992-05-04
标 题:Single arm attached cyclodextrin polysiloxanes and use thereof as chiral stationary phases in chromatographic separation of enantiomers
发明人:BRADSHAW JERALD S; LEE MILTON L; ROSSITER BRYANT E
权利人:UNIV BRIGHAM YOUNG
摘要:Cyclodextrin containing polymeric siloxanes wherein the cyclodextrin is connected to the polymeric siloxane by a single linking member connected to the 2, 3 or 6-position of the cyclodextrin are disclosed. These polymers are chemically and thermally stable to gas, supercritical fluid chromatographic conditions. The single arm attachment provides cyclodextrin containing polysiloxane polymers having synthesis reproducibility from batch to batch resulting in consistent chromatographic performance of the resulting chiral phases. The use of such polymers as chiral stationary phases in analytical and preparative gas, supercritical fluid and liquid chromatographic separations, and particularly for analysis of enantiomeric and other stereoisomeric mixtures of various substances is shown.
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主要参考文献

[参考文献]: Andreia Ascenso, Et Al. Complexation And Full Characterization Of The Tretinoin And Dimethyl-β-Cyclodextrin Complex. Aaps Pharmscitech. 2011 Jun;12(2):553-63.
[参考文献]: Fabrizio Melani, Et Al. Evaluation Of The Separation Mechanism Of Electrokinetic Chromatography With A Microemulsion And Cyclodextrins Using Nmr And Molecular Modeling. Electrophoresis. 2011 Nov;32(21):3062-9.
[参考文献]: Fei Liu, Et Al. Formulation And Evaluation Of Thienorphine Hydrochloride Sublingual Delivery System. Chem Pharm Bull (Tokyo). 2012;60(12):1479-86.
[参考文献]: Fernanda Pérez-Cruz, Et Al. Host-Guest Interaction Between New Nitrooxoisoaporphine And β-Cyclodextrins: Synthesis, Electrochemical, Electron Spin Resonance And Molecular Modeling Studies. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb:102:226-34.
[参考文献]: Hoa Thi Le, Et Al. Synthesis, Cytotoxicity, And Phase-Solubility Study Of Cyclodextrin Click Clusters. J Pharm Sci. 2014 Oct;103(10):3183-9.

合成参考文献


参考文献:10.1248/cpb.44.552
摘要:Nochi S, Yokoyama Y, Narukawa M, Ebine K, Murahashi M, Kawakami Y, Asakawa N, Sato T. Mechanism of inhibition of H+, K(+)-ATPase by sodium 2-[[4-(3- methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole (E3810). Chem Pharm Bull (Tokyo). 1996 Mar;44(3):552–8. doi: 10.1248/cpb.44.552.
参考文献:10.1248/yakushi.124.333
摘要:Miyatake N, Miyake H, Nagashima M, Takahashi M, Yasuda K, Yasuda I. [Enantiomeric determination of ephedrine derivatives in unregulated drugs using capillary electrophoresis]. Yakugaku Zasshi. 2004 Jun;124(6):333–9. doi: 10.1248/yakushi.124.333.
参考文献:10.1248/bpb.29.1229
摘要:Yokogawa K, Toshima K, Yamoto K, Nishioka T, Sakura N, Miyamoto K. Pharmacokinetic Advantage of an Intranasal Preparation of a Novel Anti-osteoporosis Drug, L-Asp-Hexapeptide-Conjugated Estradiol. Biological & Pharmaceutical Bulletin. 2006;29(6):1229–33. doi: 10.1248/bpb.29.1229.
参考文献:10.1080/03639040701655952
摘要:Shah P, Jogani V, Mishra P, Mishra AK, Bagchi T, Misra A. In Vitro Assessment of Acyclovir Permeation Across Cell Monolayers in the Presence of Absorption Enhancers. Drug Development and Industrial Pharmacy. 2008 Jan;34(3):279–88. doi: 10.1080/03639040701655952.
参考文献:10.2478/acph-2018-0016
摘要:Gu F, Ning J, Fan H, Wu C, Wang Y. Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats. Acta Pharm. 2018 Jun 01;68(2):145–57. doi: 10.2478/acph-2018-0016.
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