CAS: 467442-20-2; (S)-2-(Tert-Butoxycarbonylamino)-4,4-Difluorobutanoic Acid

英文名称(S)-2-(Tert-Butoxycarbonylamino)-4,4-Difluorobutanoic Acid
中文名称(S)-2-((叔丁氧羰基)氨基)-4,4-二氟丁酸
IUPAC名称(S)-2-((tert-butoxycarbonyl)amino)-4,4-difluorobutanoic acid
其它别名(S)-2-(叔丁氧基羰基氨基)-4,4-二氟丁酸; (S)-2-(Tert-Butoxycarbonylamino)-4,4-Difluorobutanoic Acid
CAS编号467442-20-2
MFCD编号:MFCD12755805
EINECS号:883-368-2
分子式:C9H15F2NO4
分子量:239.22
产品CID: 1463926
产品分类有机原料→分子砌块→手性化合物→手性砌块

相似结构搜索
InChIKey: UCCLBCNDXKDPDT-YFKPBYRVSA-N
InChI=1S/C9H15F2NO4/c1-9(2,3)16-8(15)12-5(7(13)14)4-6(10)11/h5-6H,4H2,1-3H3,(H,12,15)(H,13,14)/t5-/m0/s1…
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数4.0

相似化合物

944328-82-9 467442-21-3 121960-22-3

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

C&L通报

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号121960-22-3 (S)-2-氨基-4,4-二氟丁酸

合成工艺路线路线简述

二碳酸二叔丁酯,(S)-2-氨基-4,4-二氟丁酸置于三乙胺体系中,化学反应生成 (S)-2-N-叔丁氧羰基氨基-4,4-二氟丁酸
参考文献:Phe*-Ala-Based Pentapeptide Mimetics Are Bace Inhibitors: P2 And P3 Sar
标题:Phe*-Ala-Based Pentapeptide Mimetics Are Bace Inhibitors: P2 And P3 Sar
摘要:We Describe Herein The Syntheses And Evaluation Of A Series Of C-Termini Pyridyl Containing Phe*-Ala-Based Bace Inhibitors (5-19). In Conjunction With Four Fixed Residues At The P1 (Phe),P1' (Ala),P2' (Val),And P2' Cap (Pyr.),Rather Detailed Sar Modifications At P2 And P3 Positions Were Pursued. The Promising Inhibitors Emerging From This Sar Investigation,12 And 17 Demonstrated Very Good Enzyme Potency (Ic50 = 45 Nm) And Cellular Activity (Ic50 = 0.4 Mum). (C) 2003 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2003.09.084