专利号:US-3694464-A 优先权日:1968-07-10 标 题 :PREPARATION OF 1-ACETOXY-3-(ALKYL)-6,6,9-TRIMETHYL-7,8,9,10-TETRAHYDRO-6H-DIBENZO{8 b,d{9 {0 PYRAN ISOMERS 发明人:AARON HERBERT S; FERGUSON CLYDE PARKER JR 权利人:US ARMY 摘要:A novel process and novel intermediates in the synthesis of the novel optically-active isomers of 1-acetoxy-3(alkyl)-9-methyl7,8,9,10-tetrahydro-6H-dibenzo (b,d)pyran as incapacitating agents. Those intermediates are prepared by reducing a mixture comprising a ketone, an alcohol and borohydride to the carbinol, treating said carbinol with a trihalide and converting the trihalide product to a malonic ester, hydrolyzing said ester and separating the aqueous phase, acidifying said aqueous phase results in the preparation of an isomeric mixture of alkyldialkoxyhydrocinnamic acid.
专利号:CN-119899810-A 优先权日:2024-12-25 标题:Imine reductase mutant and application thereof in synthesis of chiral 1, 3-disubstituted tetrahydroisoquinoline
专利号:US-2013203709-A1 优先权日:2010-08-09 标 题 :Acylsulfonamides and processes for producing the same 发明人:MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY 权利人:MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY; PENN STATE RES FOUND; UNIV SOUTH FLORIDA 摘要:The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
专利号:WO-2024159284-A1 优先权日:2023-01-30 标题 :Nav1.7- and/or nav1.8-inhibiting hydrazides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits 发明人:BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA 权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ 摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting hydrazides. More specifically, the present invention relates to hydrazides comprising formula (I):(I), in which the substituents R1 to R8 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.
专利号:CN-112209841-B 优先权日:2020-10-22 标 题 :Synthesis method of terbutaline and application of terbutaline in preparation of terbutaline sulfate
[参考文献]: Salem S Alghamdi, Et Al. Comparative Phytochemical Profiling Of Different Soybean ( Glycine Max (L.) Merr) Genotypes Using Gc-Ms. Saudi J Biol Sci. 2018 Jan;25(1):15-21.
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