CAS: 368-43-4; Benzenesulfonyl Fluoride

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CAS号882-33-7 二苯二硫醚 | CAS号1212-08-4 S-苯基硫代苯基砜 | CAS号98-09-9 苯磺酰氯 | CAS号3204-68-0 苄基二甲基苯基氯化铵 | CAS号873-55-2 苯亚磺酸钠 | CAS号17067-71-9 tris(2,3,4,5,6-... | CAS号657-98-7 Benzolsulfinsae... | CAS号98-13-5 苯基三氯硅烷 | CAS号98-10-2 苯磺酰胺 | CAS号455-32-3 苯甲酰氟 | CAS号93-97-0 苯甲酸酐 | CAS号512-35-6 苯磺酸酐 | CAS号420-56-4 三甲基氟硅烷 | CAS号84224-37-3 (1-tert-Butylvi... | CAS号84224-39-5 (1-Phenylvinyl)... | CAS号16670-48-7 苯磺酸2-氯乙酯 | CAS号2845-62-7 异氰酸苯磺酰酯 | CAS号84224-42-0 (2-Methyl-1-pro... | CAS号84224-44-2 (Cyclohexen-1-y...

📜二苯二硫醚置于selectfluor体系中,用 水,乙腈 作为反应溶剂,化学反应 2.03H,反应生成 苯磺酰氟
参考文献:用亲电子卤化试剂氧化二硫化物:制备硫代磺酸盐和磺酰卤的简明方法
标题:用亲电子卤化试剂氧化二硫化物:制备硫代磺酸盐和磺酰卤的简明方法
摘要:在室温下,芳族或苄基二硫化物与2.5当量的selectfluor™在乙腈/水(10:1)中的反应有效地产生了相应的硫代磺酸盐.相反,在回流的乙腈/水(10:1)中,二硫化物与6.5当量的selectfluor™或硫代磺酸盐与4.5当量的selectfluor™的反应以高收率提供了磺酰氟.accufluor™和fp-T300™在相似的反应条件下也可有效地由二硫化物制备磺酰氟.从二硫化物与6当量的n-氯代琥珀酰亚胺或n的反应中可有效获得磺酰氯或磺酰溴-溴琥珀酰亚胺在室温下于乙腈/水(10:1)中溶解.还可以使用其他一些亲电氯化或溴化试剂代替n-氯琥珀酰亚胺或n-溴琥珀酰亚胺来由二硫化物合成磺酰卤.二硫化物与亲电子卤化试剂的这些反应是制备硫代磺酸盐和磺酰卤的方便方法.
DOI:10.1016/j.Tet.2014.02.013

专利信息

专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.

专利号:WO-2025081225-A1
优先权日:2023-10-17
标 题 :Synthesis of polyphenols
发明人：TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
权利人:Delica Therapeutics Pty Ltd
摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

专利号:US-7625735-B2
优先权日:1998-10-12
标 题:Recombinant kinase from insect cells for the synthesis of nucleoside monophosphates
发明人：IHLENFELDT HANS-GEORG; MUNCH-PETERSEN BRIGITTE; PISKUR JURE; SONDERGAARD LEIF
权利人:ROCHE DIAGNOSTIC OPERATIONS IN
摘要:A recombinant Drosophila melanogaster deoxynucleoside kinase that remains stable during the synthesis of nucleoside monophosphate without the addition of stabilizing SH reagents or stabilizing proteins, and that accepts all four natural deoxynucleotides is provided. In addition, the invention concerns DNA sequences, vectors, transformed cells, a method for production of the recombinant kinase as well as its use for preparing nucleoside monophosphates.

专利号:US-2007048774-A1
优先权日:1998-05-08
标题 :Continuous in-vitro evolution
发明人：COIA GREGORY; HUDSON PETER J; ILIADES PETER; IRVING ROBERT A
权利人:DIATECH PTY LTD
摘要:Provided is a method for the mutation, synthesis and selection of a protein of interest, by first incubating a replicable RNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, such that the RNA-directed RNA polymerase replicates the RNA molecule but introduces mutations thereby generating a population of mutant RNA molecules. The mutant RNA molecules are then incubated with a translation system under conditions which result in the synthesis of a population of mutant proteins. After translation, the mutant proteins are linked to their encoding RNA molecules, and one or more mutant proteins of interest are selected.

专利号:US-6562622-B1
优先权日:1998-05-08
标 题:Continuous in vitro evolution
发明人：COIA GREGORY; HUDSON PETER JOHN; ILIADES PETER; IRVING ROBERT ALEXANDER
权利人:DIATECH PTY LTD
摘要:The present invention provides a method for the mutation, synthesis and selection of a protein which binds to a target molecule, the method comprising: (a) incubating a replicable mRNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, wherein the RNA-directed RNA polymerase replicates the mRNA molecule but introduces mutations thereby generating a population of mutant mRNA molecules; (b) incubating the mutant mRNA molecules from step (a) with a translation system under conditions which results in the synthesis of population of mutant proteins such that after translation, mutant proteins are linked to their encoding mRNA molecules thereby forming a population of mutant proteins such that after translation, mutant proteins are linked to their encoding mRNA molecules thereby forming a population of mutant/mRNA complexes; (c) selecting one or more mutant protein/mRNA complex(es) by exposing the population of mutant protein/mRNA complexes from step (b) to the target molecule and recovering the mutant protein/mRNA complex(es) bound thereto.

专利号:US-5104856-A
优先权日:1990-11-09
标题:Heparan sulfate biosynthesis primers
发明人：ESKO JEFFREY D; LUGEMWA FULGENTIUS N
权利人:UAB RESEARCH FOUNDATION
摘要:Conjugates of β-D-xylose with estrogens or modified forms of estrogens are effective in stimulating the synthesis of heparan sulfate, and inhibiting the production of proteoglycan in animal subjects. Accordingly, these conjugates are useful in treating conditions where antithrombotic or antiproliferative activity is desirable.