CAS: 32864-38-3; Tert-Butyl Ethyl Malonate

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16695-14-0 40052-13-9 1071-46-1

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CAS号1071-46-1 丙二酸单乙酯 | CAS号75-65-0 叔丁醇 | CAS号36239-09-5 丙二酸单乙酯酰氯 | CAS号115-11-7 2-甲基丙烯 | CAS号540-88-5 醋酸叔丁酯 | CAS号4303-71-3 SODIUM, TRIPHEN... | CAS号105-53-3 丙二酸二乙酯 | CAS号1010117-23-3 diethyl 2-nitro... | CAS号201230-82-2 carbon monoxide | CAS号615-09-8 3-(2-糠基)-3-氧丙酸乙酯 | CAS号40052-13-9 丙二酸单叔丁酯 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号25022-02-0 ethyl 3-oxo-4,4... | CAS号718-08-1 3-氧-4-苯基-丁酸乙酯 | CAS号15971-92-3 3-环己基-3-氧代丙酸乙酯 | CAS号17071-29-3 3-Oxo-5-Phenyl-... | CAS号820215-84-7 ethyl 6-methyl-... | CAS号89317-64-6 4-ethoxy-2-etho... | CAS号94242-51-0 莫西沙星三氟乙酯

丙二酸单乙酯,异丁烯置于硫酸体系中,用 二氯甲烷 作为反应溶剂,以77%的收率获得产物丙二酸叔丁基乙酯
参考文献:设计,合成和评估分支酸突变酶的氮杂抑制剂.
标题:设计,合成和评估分支酸突变酶的氮杂抑制剂.
摘要:设计,制备并制备了一系列支链状酸突变酶(ec 5.4.99.5)的氮杂抑制剂(4-9),并通过监测对支链状酸1(直接向苯甲酸酯2)转化的直接抑制作用,对该酶进行了评估.这些氮杂抑制剂均未显示出比天然底物分支酸更紧密的结合酶或比先前报道的醚类似物更强的抑制作用.3此外,在存在两种潜在反应性氮杂的情况下,未观测到酶活性的时间依赖性损失.抑制剂(7和9).这些结果与来自更广泛的分支酸突变酶抑制剂的抑制数据相结合,为提出分支酸突变酶的机械作用提出了新的建议.该拟议的机制进行了计算验证,并与各种分支酸突变酶的晶体学研究相关联.
DOI:10.1016/j.Bmc.2004.06.037

专利信息

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-8884051-B2
优先权日:2010-10-20
标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
发明人：MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C
权利人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C; BIOFORMIX INC
摘要:The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

专利号:US-8148568-B2
优先权日:2006-05-25
标题 :Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (−)-R-homocitric acid gamma-lactone, (+)-S-homocitric acid gamma-lactone and the corresponding (−)-R-homocitric acid and (+)-S-homocitric acid salts
发明人：LOPP MARGUS; PAJU ANNE; EEK MARGUS; LAOS MARIT; PEHK TONIS; JAALAID RAISSA
权利人:LOPP MARGUS; PAJU ANNE; EEK MARGUS; LAOS MARIT; PEHK TONIS; JAALAID RAISSA; UNIV TALLINN TECHNOLOGY; CAMBREX TALLINN AS
摘要:Archiral (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid) alkyl, alkylphenyl and phenyl esters, and a simple and efficient method for the synthesis of both enantiomers of homocitric acid gamma-lactone and the corresponding salts from these esters are described. The method is based on asymmetric oxidation of esters, and the steps of basic and acidic hydrolysis and final acidic lactonization of the homocitric acid into homocitric acid gamma-lactone. The homocitric acid salts are obtained after basic treatment of homocitric acid gamma-lactone. The esters, conditions and reagents used in chemical conversion and separating products are important constituents affording efficient and simple method for production of homocitric acid gamma-lactone and homocitric acid salts.

专利号:CA-2815198-A1
优先权日:2010-10-20
标题 :Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent

专利号:US-4914226-A
优先权日:1986-07-16
标 题 :Malonic acid derivatives and methods for their synthesis
发明人：DI TRAPANI ROMANO; VERDINI ANTONIO S
权利人:ENIRICERCHE SPA; SCLAVO SPA
摘要:The present invention refers to a new class of malonic acid derivatives of general formula I ##STR1## wherein R 1 and R 2 , each independently, represent hydrogen or a carboxyl protecting group, and the residue R corresponds to the side-chain of the amino acids lysine, ornithine, tyrosine, cysteine, asparatic acid and glutamic acid wherein the additional functionalities are suitably protected. The new compounds of the present invention are useful for preparing analogues of biologically active peptides wherein the direction of some amide bonds in which the amino acids lysine, ornithine, tyrosine, cysteine, aspartic acid or glutamic acid are involved, has been reversed.

专利号:WO-2012054633-A2
优先权日:2010-10-20
标 题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent