CAS: 324763-39-5; (R)-4-(2-(Chloromethyl)-3-Methylbutyl)-1-Methoxy-2-(3-Methoxypropoxy)Benzene

该化合物是一个复杂的有机化合物,具有多功能结构特征,其特点是一种以不同组别(包括甲基氧组和丙氧组)替代的苯环,有助于其溶解性和再活性;氯甲基组的存在表明有可能进一步进行化学改造,而丁基链的2位置的阳性中心表明,该化合物可能表现出立体异构体主义,这可能影响其生物活动和相互作用;该化合物由于其独特的结构特征,可能对医药化学或材料科学感兴趣,其物理特性,如熔点,沸点和溶性,将取决于其亚组别的具体安排和整体分子相互作用;与许多有机化合物一样,应当注意安全和处理预防措施,特别是由于氯的存在,它可能构成健康风险.

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CAS号172900-70-8 (R)-2-[3-(3-甲氧基... | CAS号172900-75-3 3-(3-甲氧基丙氧基)-4-... | CAS号503-74-2 异戊酸 | CAS号324763-36-2 (E)-3-(4-methox... | CAS号172900-74-2 3-(3-甲氧基丙氧基)-4-... | CAS号172900-71-9 (ar)-4-甲氧基-3-(3... | CAS号324763-46-4 5(S)-[1(S)-叠氮基-... | CAS号387353-71-1 (2S,4E,7R)-7-[4... | CAS号173334-57-1 阿利吉仑 | CAS号324763-47-5 (αS,γS,δS,ζS)-N... | CAS号900811-38-3 (R)-[2-碘甲基-3-甲基...

合成工艺路线路线简述

    📜异戊酸置于palladium On Activated Charcoal Titanium(Iv) Isopropylate,4-二甲氨基吡啶,Sodium Tetrahydroborate,N-氯代丁二酰亚胺,氢气,四氯化钛,溶剂黄146,N,N-二异丙基乙胺,三苯基膦体系中,用 四氢呋喃,1,1-二氯乙烷,二氯甲烷 作为反应溶剂,-40.0~70.0 °C,392.27 Kpa 条件下,反应 32.5H,反应生成 4-[(2R)-2-(氯甲基)-3-甲基丁基]-1-甲氧基-2-(3-甲氧基丙氧基)苯
    参考文献: Process For The Preparation Of (2S,4S,5S,7S)-N-(2-Carbamyl-2-Methylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]-octanamide Hemifumarate And Its Intermediates Thereof[fr] Procédé Pour Préparer Un Hémifumarate Du Composé (2S,4S,5S,7S)-N-(2-Carbamoyl-2-Méthylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Méthoxy-3-(3-Méthoxypropoxy)Phényl]-octanamide Et Produits Intermédiaires Correspondants
    标题: Process For The Preparation Of (2S,4S,5S,7S)-N-(2-Carbamyl-2-Methylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]-octanamide Hemifumarate And Its Intermediates Thereof[fr] Procédé Pour Préparer Un Hémifumarate Du Composé (2S,4S,5S,7S)-N-(2-Carbamoyl-2-Méthylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Méthoxy-3-(3-Méthoxypropoxy)Phényl]-octanamide Et Produits Intermédiaires Correspondants
    摘要:本发明涉及一种制备(2S,4S,5S,7S)-N-(2-羰基-2-甲基丙基)-5-氨基-4-羟基-2,7-二异丙基-8-[4-甲氧基-3-(3-甲氧基丙氧基)苯基]-辛酰胺化合物的方法,其化学式为1,以及其在药学上可接受的盐.此外,涉及制备(R)-4-(2-(卤甲基)-3-甲基丁基)-1-甲氧基-2-(3-甲氧基丙氧基)苯和(R)-2-(4-甲氧基-3-(3-甲氧基丙氧基)苄基)-3-甲基丁醇的方法,这些是化合物1合成中有用的中间体.

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    专利信息


    专利号:WO-2011148392-A1
    优先权日:2010-05-28
    标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
    发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
    权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
    摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.

    专利号:US-8563279-B2
    优先权日:2007-12-24
    标题 :Convergent synthesis of renin inhibitors and intermediates useful therein
    发明人：DE LANGE BEN; CASTELIJNS ANNA MARIA CORNELIA FRANCISCA; DE VRIES JOHANNES GERARDUS; DE VRIES ANDREAS HENDRIKUS MARIA; BOOGERS JEROEN ANTONIUS FRANCISCUS; BROXTERMAN QUIRINUS BERNARDUS
    权利人:DE LANGE BEN; CASTELIJNS ANNA MARIA CORNELIA FRANCISCA; DE VRIES JOHANNES GERARDUS; DE VRIES ANDREAS HENDRIKUS MARIA; BOOGERS JEROEN ANTONIUS FRANCISCUS; BROXTERMAN QUIRINUS BERNARDUS; DSM IP ASSETS BV
    摘要:Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R 4 being a branched C 3 — 6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).

    专利号:EP-2313386-B1
    优先权日:2008-07-23
    标 题:Synthesis routes to 2(s),4(s),5(s),7(s)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides
    发明人：VRIES DE ANDREAS HENDRIKUS MARIA; VERZIJL GERARDUS KAREL MARIA; HERMSEN PETRUS JOHANNES; CASTELIJNS ANNA MARIA CORNELIA FRANCISCA
    权利人:DSM IP ASSETS BV
    摘要:The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.

    专利号:WO-2009080773-A1
    优先权日:2007-12-24
    标题:Convergent synthesis of renin inhibitors and intermediates useful therein

    专利号:US-2013310577-A1
    优先权日:2007-12-24
    标题:Convergent synthesis of renin inhibitors and intermediates useful therein

    专利号:EP-2225200-B1
    优先权日:2007-12-24
    标题 :Convergent synthesis of renin inhibitors and intermediates useful therein

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    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2007).
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